Protein

Protein accession
A0A1S5VY25 [UniProt]
Representative
7owJl
Source
UniProt (cluster: phalp2_14099)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MWNARATGLSVGDHVEAGQLIGYIGSNGQSTGPHLHITVWDRGYNSLRIDPEVWLASAGFPGESVAAPKPATGEPIWGIDVSNHQGNFDFAAAKAEGFMFATHKVTEGTGYRDPYWARARQEMEKHFPGRWGGYVFCRTNTDPATEARYFYDAVGGDTSVPVQIDYEDTTNGGNGADLFNRVRAFQDLGFRLLPIYIPRWFWRDHMGSPDLSGLPVPIWNSHYVRGVDYASNLYAKHGEKNNAWSDMGGKPVSILQFSETAMVAGKLIDVNAFRGTEAELDELFSGQELSMSAVQEIKDYIDIRVTNPIGSDVKDLREQACGQGARDAGQYNGWPQLGGRTVADALAVIGVALNIEGFFDPRSIG
Physico‐chemical
properties
protein length:365 AA
molecular weight:40033,0 Da
isoelectric point:5,07
hydropathy:-0,37
Representative Protein Details
Accession
7owJl
Protein name
7owJl
Sequence length
324 AA
Molecular weight
36450,17090 Da
Isoelectric point
5,48112
Sequence
MTLYGIDVSNHQGNFDFAAAKREGFVFATHKVTEGDGYRDPYWPRARDQMREHFPGLFGGYHFARNNIDPDRQADALLAHLGDPSIPVQLDYEDTKTRGSIDNMKALIRAIEKRGMRVFANYLPRWYWTGHMGAPRLDGTPPIWNSHYVNGTGYASVLYPGDGHAGWAEFHTGAPPVVLLQFSERGQVAGQSIDVNAFRGTEQELRALFGSAQPKGEPVTDIVEQGAGQLHPQPGRLRPIQRPQNVNPSTRPPDEPWPYDVWCDLWNESVWDGYDIRPEYADVPDEVGRSLVSLLQTVAARQVCERAQLDRIESKLDRLLGGEQ
Other Proteins in cluster: phalp2_14099
Total (incl. this protein): 20 Avg length: 322,7 Avg pI: 5,51
Protein ID Length (AA) pI
7owJl 324 5,48112
3V5aY 325 5,39632
73tci 325 5,47737
76t3b 325 5,30043
7AGQh 306 6,10209
7b8k2 317 5,80794
7dHuR 321 5,32515
7dTdh 323 5,66181
7mBje 319 5,87825
7moM5 325 5,77680
7o2TC 308 5,57354
7o30r 313 5,05443
7o3b5 308 5,57354
7pNLN 332 4,31336
7rr0W 324 5,38080
8IKAY 325 5,67113
8LA9J 306 6,27067
A0A1S5VYA1 367 5,01925
A0A899INN4 295 6,15546
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_22258
7lGFm
 11 61,4% 210 4.838E-102
2 phalp2_20034
1pbFu
 55 46,1% 219 4.227E-66
3 phalp2_36898
7vYe1
 51 42,0% 219 7.740E-48
4 phalp2_25713
4FbaX
 14 39,4% 218 2.442E-44
5 phalp2_10481
415Yr
 125 32,6% 334 2.247E-39
6 phalp2_8437
Ypuv
 26 35,0% 228 7.708E-39
7 phalp2_4989
6SNir
 5 33,4% 239 5.736E-37
8 phalp2_22077
5JqEY
 8 34,7% 262 5.736E-37
9 phalp2_16820
1owxb
 15 34,9% 249 1.962E-36
10 phalp2_1777
2SfqX
 42 34,7% 216 3.113E-35

Domains

Domains [InterPro]
GH25
Disordered region
Representative sequence (used for alignment): 7owJl (324 AA)
Member sequence: A0A1S5VY25 (365 AA)
1 324 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Rhodococcus phage AngryOrchard
[NCBI] 		1955425 Rerduovirus > Rhodococcus virus Takoda
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KY549153 [NCBI]
CDS location
range 1971 -> 3068
strand +
CDS
ATGTGGAACGCCCGAGCTACCGGCCTTTCGGTCGGTGACCACGTCGAGGCCGGCCAACTGATCGGCTATATCGGCAGCAACGGCCAGTCCACTGGACCCCACCTGCACATCACGGTCTGGGATCGCGGATACAACAGTCTCCGCATCGACCCCGAGGTCTGGCTGGCATCTGCCGGCTTCCCCGGTGAATCCGTGGCGGCTCCCAAGCCGGCCACCGGTGAGCCGATCTGGGGTATCGACGTTTCCAACCACCAGGGCAACTTCGACTTCGCTGCCGCGAAGGCCGAGGGCTTCATGTTCGCCACTCACAAGGTGACAGAGGGTACCGGCTACCGCGACCCGTACTGGGCTCGCGCTCGCCAGGAGATGGAGAAGCACTTCCCAGGTCGTTGGGGTGGTTATGTGTTCTGCCGCACCAACACTGACCCTGCAACCGAGGCACGGTACTTCTATGACGCAGTCGGCGGTGACACTTCGGTGCCCGTCCAGATCGACTACGAGGACACCACGAACGGCGGCAACGGCGCTGACCTGTTCAACCGGGTCCGTGCGTTCCAGGATCTCGGGTTCCGGCTTCTGCCGATCTACATTCCCCGGTGGTTCTGGCGGGATCACATGGGCAGCCCGGATCTTTCGGGCCTGCCGGTTCCGATCTGGAACTCCCACTACGTGCGAGGCGTGGACTACGCATCCAACCTCTACGCCAAGCATGGCGAGAAGAACAACGCATGGTCTGACATGGGCGGTAAGCCCGTGAGCATTCTCCAGTTCTCGGAGACGGCGATGGTCGCCGGCAAGTTGATCGACGTAAACGCCTTCCGAGGCACAGAGGCTGAACTTGACGAACTGTTCAGCGGACAGGAACTTTCCATGAGCGCAGTGCAGGAAATCAAGGACTACATCGACATTCGCGTCACGAACCCGATCGGTTCCGACGTGAAGGATCTCCGCGAACAGGCTTGCGGTCAAGGTGCCCGCGATGCCGGCCAATACAACGGCTGGCCGCAGCTCGGAGGTCGCACCGTCGCAGATGCCCTCGCCGTAATCGGTGTGGCTCTCAACATCGAAGGATTTTTCGACCCACGAAGTATCGGATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7owJl) rather than this protein.
PDB ID
7owJl
Method AlphaFoldv2
Resolution 76.98
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50