Protein

Protein accession
A0A1B0Y4N7 [UniProt]
Representative
5j1l4
Source
UniProt (cluster: phalp2_25839)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKLKTKLITLVVAFLAAISFALPSQVNAAKGDQGPDWAKYQGASGRYGTDQDKFVIAQIGGTYGGTYIDQWTYDSQIASAKAAGKRVHSYIWYGVGASSQLGLEALDRYMPRIKAQTPKGSIVALDYEDGASGNMAANTDAILAGMRRIHSEGYTPMYYSYKPYTLAHVDYQRILKEFPNSLWIAAYRDYLPTTKPDYGYFPSMDGVAIWQYTSAFGLSQGLDGNIDLLGITDNGYSSQPETPSAPVTPVPSQPAKSNAASDSDYAQTGVFKPSTTVNIRTGAGTGYTAVGSYVPGESLVYDHVYIRGSYVWARYLSYSGRYHYVALGVNGGESYGSRSSGYTSLVSHTYYTVRSGDSFWSIASKYGISMYTLAANNGKSIYSLIYPGESLYIK
Physico‐chemical
properties
protein length:394 AA
molecular weight:42886,4 Da
isoelectric point:8,56
hydropathy:-0,27
Representative Protein Details
Accession
5j1l4
Protein name
5j1l4
Sequence length
275 AA
Molecular weight
30147,94150 Da
Isoelectric point
6,06020
Sequence
GSIVALDYEDGASGNMAANTDAILAGMRRIHSEGYTPMYYSYKPYTLAHVDYQRILKEFPNSLWIAAYRDYLPTTKPDYGYFPSMDGVAIWQYTSAFGLSQGLDGNIDLLGITDNGYSKQPETPSASVTPAPSQPAKSNAASDTDYAQTGVFKPSTTVNIRTGAGTGYASVGSYAPGESVIYDHVYIRGTYVWARYLSYSDRYHYVALGVNGGESYGSRSSGYTSLVSHTYHTVRYGDSFWSIASKYGISMYTLAANNGKSIYSLIYPGENLYIR
Other Proteins in cluster: phalp2_25839
Total (incl. this protein): 12 Avg length: 347,6 Avg pI: 8,30
Protein ID Length (AA) pI
5j1l4 275 6,06020
1QQbt 270 9,30087
1Z0uo 377 9,30042
28wXu 354 9,41549
651Zx 285 9,03010
73Bte 269 4,71652
A0A0P0HRN9 394 8,56142
Q6J1W8 393 8,56838
A0A9E8K283 394 8,56077
A0AAE9VYJ7 373 8,76333
A0AAF0B0E0 393 8,74747
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_144
5oGmc
 8 93,7% 191 3.590E-101
2 phalp2_17635
6JmE3
 482 38,2% 282 1.699E-44
3 phalp2_38217
7u45O
 5 30,4% 282 6.854E-23
4 phalp2_22096
5ZSom
 2292 26,9% 282 2.211E-20
5 phalp2_29108
6ZCjl
 6 34,5% 171 3.372E-19
6 phalp2_26548
858CP
 728 25,8% 278 1.527E-15
7 phalp2_9283
7cTgF
 101 26,3% 273 1.233E-14
8 phalp2_362
76MmF
 5 27,0% 274 9.889E-14
9 phalp2_5407
2G2v9
 4 19,5% 245 7.873E-13
10 phalp2_15728
3kqKZ
 1 26,1% 195 1.218E-09

Domains

Domains [InterPro]
GH25
Unannotated
LysM
Representative sequence (used for alignment): 5j1l4 (275 AA)
Member sequence: A0A1B0Y4N7 (394 AA)
1 275 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage PLE3
[NCBI] 		1815510 Pleetrevirus > Pleetrevirus PLE3
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KU848186 [NCBI]
CDS location
range 20356 -> 21540
strand +
CDS
ATGAAACTAAAAACTAAACTAATTACCTTGGTAGTCGCCTTCTTGGCGGCTATTTCTTTTGCCCTGCCATCGCAGGTCAATGCGGCCAAGGGTGATCAGGGCCCGGATTGGGCGAAGTATCAGGGAGCAAGTGGACGATATGGAACAGATCAAGACAAGTTCGTCATAGCTCAGATTGGCGGAACTTACGGTGGTACGTACATCGATCAGTGGACGTATGATAGCCAAATTGCTAGTGCCAAGGCGGCAGGAAAACGTGTGCATAGCTACATCTGGTATGGTGTTGGTGCAAGTAGCCAGTTGGGATTAGAAGCACTTGACCGTTATATGCCTCGTATCAAAGCACAGACGCCAAAGGGAAGCATCGTTGCTTTGGATTACGAAGATGGTGCTTCTGGGAATATGGCAGCTAATACGGATGCAATTTTAGCTGGTATGCGGCGCATTCATTCCGAAGGCTACACGCCCATGTATTACAGTTACAAGCCATATACATTGGCACACGTCGATTATCAGCGTATTCTGAAAGAATTTCCTAACAGCCTTTGGATTGCTGCTTACCGTGATTATCTACCAACTACCAAACCAGACTACGGTTATTTTCCGAGTATGGATGGGGTAGCTATTTGGCAGTACACGAGCGCATTTGGGCTGTCGCAAGGCCTCGATGGTAACATTGATCTGCTTGGTATCACTGATAATGGCTACTCGAGCCAACCAGAAACCCCGTCAGCACCTGTAACACCGGTGCCAAGCCAACCAGCGAAATCAAATGCAGCCAGTGATTCCGACTATGCGCAAACTGGTGTTTTCAAGCCTTCCACGACTGTTAACATCCGCACTGGTGCTGGTACAGGATACACGGCAGTTGGCAGCTATGTGCCGGGTGAGAGCCTTGTGTATGATCATGTGTATATTCGCGGTTCATACGTCTGGGCACGGTACCTCAGCTACTCCGGTCGGTATCATTATGTTGCCTTGGGCGTGAATGGTGGGGAGAGCTATGGCTCGCGTTCGTCTGGATATACTTCGCTGGTAAGCCACACGTATTATACAGTCCGCTCTGGTGACAGCTTCTGGAGTATTGCCAGCAAGTATGGCATCAGCATGTACACACTGGCAGCCAACAATGGCAAGTCAATCTACAGTTTGATTTACCCAGGTGAAAGCCTGTACATCAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000176a623_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5j1l4) rather than this protein.
PDB ID
5j1l4
Method AlphaFoldv2
Resolution 78.96
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50