Protein

Protein accession
A0A172JII6 [UniProt]
Representative
7uM5Y
Source
UniProt (cluster: phalp2_17753)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MSLNIIETYLTPNGEPRKGNRPLFLILFSSERSGCSIYDLDREDKYENGKTMFRGHFFISKEGVIFRGRSLDTIGEFAHDDQTGMDFNRNSIGICVEGDYTSELMPTIQKNSIVLLIQYLRNNNSTLKTIYALDEILTDKSNPGIFFPLNEIIANVLNVSIEPVRKAPNGLLRYAFGNRTLYFDSKKPITGNDVTELQTMLNLFGFNCDTNGYFDNTTMLAVLNFQKSYNLIPDGIVNDETFSLIKKLSLKFFENRMTFSRILYFDNNNQLYGNDIKRLQNRLQLLGYECNSNGFYDSSTESAVKNFQESHSLTVDGKVGPITWSQITDTSFTFIKRTLMYTTPMLFGDDVRLVQQRLNDLGYILEPTGWFDETTMQAVIKFQSSKGMKADGIINDSTAKQLFK
Physico‐chemical
properties
protein length:404 AA
molecular weight:46135,8 Da
isoelectric point:5,47
hydropathy:-0,33
Representative Protein Details
Accession
7uM5Y
Protein name
7uM5Y
Sequence length
252 AA
Molecular weight
28009,51740 Da
Isoelectric point
9,16516
Sequence
MKIFIDPGHGGSDSGATGNGLLEKDIVLDISLKEAKLFKELGHDVKLSRSSDIYIPLSRRALGANNWGADLFISNHVNAGGGIGSEVWHSIYGGKGKEYASRVEENLAEIFKSRGIKSKKGQNGDYLYVIRNTKMPTILNEFGFIDNLGDSQKLKREDIRQKCAEAVVFGICHESKISNATLKRLLKLTQPMQYGDDVKLVQTYLNKQGYYCNIDGWYGSNTKKAIMNFQNRNGLSVDGIVGNNTWDALRRI
Other Proteins in cluster: phalp2_17753
Total (incl. this protein): 14 Avg length: 321,2 Avg pI: 7,31
Protein ID Length (AA) pI
7uM5Y 252 9,16516
1c7Wz 322 9,45740
2UlNi 238 7,76974
5i29U 315 9,24697
5ipHw 313 5,50977
7FJnY 295 6,89357
7epUT 374 5,87985
7i80q 266 10,13077
7w9RM 340 9,76711
A0A223LCP5 404 5,47072
A0A345ASR5 285 5,93157
A0A345ATK2 285 5,80488
A0AAE9YL72 404 5,80686
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_18568
7cu0D
 39 40,0% 180 3.450E-52
2 phalp2_26225
oqMn
 4 34,8% 267 1.059E-47
3 phalp2_29154
7mKv1
 17 26,8% 343 5.508E-45
4 phalp2_17577
6kJnH
 104 41,4% 176 3.592E-44
5 phalp2_24413
4m1OU
 1246 42,7% 192 1.254E-43
6 phalp2_1949
4uL4w
 13 39,1% 179 5.317E-42
7 phalp2_11834
8nufL
 33 39,8% 178 4.727E-41
8 phalp2_11898
2lint
 4 35,8% 184 3.073E-40
9 phalp2_26616
7oxe5
 7 39,5% 187 1.769E-38
10 phalp2_27233
3PKbz
 18 37,1% 183 2.139E-37

Domains

Domains [InterPro]
Ami3
PG_1
Representative sequence (used for alignment): 7uM5Y (252 AA)
Member sequence: A0A172JII6 (404 AA)
1 252 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471, PF01520

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage AR9
[NCBI] 		1815509 Takahashivirus > Bacillus phage PBS1
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KU878088 [NCBI]
CDS location
range 227745 -> 228959
strand -
CDS
ATGTCATTAAATATCATAGAGACATATCTAACTCCTAATGGAGAGCCAAGAAAGGGGAACAGACCACTGTTCCTCATTCTTTTTAGTTCTGAAAGATCGGGTTGTTCCATTTATGATTTAGATAGAGAAGATAAATATGAGAATGGAAAGACTATGTTTAGAGGTCATTTTTTTATCTCAAAAGAAGGTGTTATTTTTAGAGGAAGATCTTTAGATACAATTGGCGAATTTGCTCATGATGATCAAACAGGAATGGACTTCAATAGAAATAGTATTGGAATTTGCGTAGAAGGTGATTATACATCCGAATTAATGCCAACTATACAAAAGAATTCAATTGTTTTACTCATACAATACTTAAGAAATAATAATTCTACTCTAAAAACTATATACGCTTTAGATGAGATTCTTACTGATAAAAGCAATCCAGGAATATTCTTTCCATTGAATGAGATTATAGCCAATGTACTTAATGTGTCAATTGAGCCTGTAAGAAAAGCACCTAATGGATTATTGAGATATGCATTTGGTAACAGAACACTATACTTTGATTCAAAAAAGCCTATCACTGGTAATGATGTAACAGAATTACAAACAATGTTAAATCTATTTGGATTCAACTGTGATACTAATGGATATTTTGACAATACTACCATGTTAGCAGTACTTAATTTCCAAAAAAGCTATAATTTAATTCCAGATGGAATAGTTAATGACGAGACTTTTAGTCTTATAAAGAAATTATCATTAAAATTTTTTGAAAATAGAATGACCTTTTCTAGAATATTATACTTTGATAACAATAATCAGTTATATGGAAATGATATTAAGCGATTACAGAATAGATTACAACTTTTAGGTTATGAGTGTAATTCTAATGGTTTTTATGATAGTAGTACTGAATCTGCGGTTAAAAATTTTCAGGAATCACATTCATTAACTGTAGATGGAAAAGTTGGACCAATTACATGGAGTCAAATTACTGACACAAGTTTTACTTTTATAAAAAGGACACTTATGTATACTACTCCTATGTTATTTGGTGATGATGTTCGTTTAGTACAGCAACGTTTAAATGACTTAGGCTATATATTAGAACCTACCGGATGGTTTGATGAGACTACTATGCAAGCAGTTATTAAATTTCAATCATCTAAGGGAATGAAAGCTGATGGGATTATAAATGATTCTACAGCGAAGCAATTATTTAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7uM5Y) rather than this protein.
PDB ID
7uM5Y
Method AlphaFoldv2
Resolution 95.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50