Protein

Protein accession
A0A0P0I7S1 [UniProt]
Representative
7pnLO
Source
UniProt (cluster: phalp2_6348)
Protein name
Tail lysin
Lysin probability
99%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSIHDWFDRHIGTITYSMYGSRNGADGTADCSGSVSQALKEAGYNISGLPSTVSLGSQLAANGFTRIHVWAGGGDNGWDVSMDDIVLMSWSSAGMAYSGGAGGHVGIIHDDAETFESCDYWTGGQANTAITRHDVTAYINNSISNGLRYYEVWRKGGSTPSAPVQNNTAAVKKVNVTYGLKLKNGGWLDPVTNFGAGDEGFAGLPNHAHDLLYIRVDHGGLQYRVSTLEDGWLDWVYKGDPNDTVNGCAGIVGHTIDKVQMIYLTPAGEPYQQAYYRTQTTARENWLDVCCDDGTSIALYDGWAGMPGEPLDRLQIGIGSVSPF
Physico‐chemical
properties
protein length:324 AA
molecular weight:34827,0 Da
isoelectric point:4,81
hydropathy:-0,30
Representative Protein Details
Accession
7pnLO
Protein name
7pnLO
Sequence length
475 AA
Molecular weight
52148,57180 Da
Isoelectric point
6,59704
Sequence
MGQKETATQIWTYLIGCGWSKTAVAALLGNMQSESGIIADRWEGDIVGNMNGGYGLVQWTPATKFINWAKSNGLDYRDVISQCKRIEWEVKNNQQFSCPSMTFYQFKVSTDSPENLANIFIKYYERPANPNQPARAQQARYWYNLLQGVNPTPKVKVIDWFNKHRGHITYSMDGSRIGTDGTADCSGSIVIALKESTGVPFQYVYNTVTLGGYLAKCGYSRVLTGNSSGSNLNQVKDEDIILLSCGNSMAESGGAGGHTGVISGGGKNITSTCYYTQGEKNTAIQDITLNRDYLTYDGFKYYEVWRPSGTPNPGPNPTPIEFSTNVHYGLRVLGGSWLGEVTNFNNVDSNGFAGLPYNQHDMLYIKVDQGTVKYRTHSAKSGWLSWVTQGNPNDLYNGCAGNPGEAIDGVQIYYTTPAGKTLSQCYYRSQTTARSGWLGVCCDDGTSISGFDGWAGMFGEPLDRLQIGISTKNPF
Other Proteins in cluster: phalp2_6348
Total (incl. this protein): 8 Avg length: 364,6 Avg pI: 5,40
Protein ID Length (AA) pI
7pnLO 475 6,59704
A0A514AAP6 357 5,19909
A0A7T7ZAH2 352 5,47106
A0A6B9SW22 358 5,49601
A0A5Q2W7N7 352 5,29600
A0A5Q2WDB8 343 4,96104
A0A977SLX7 356 5,34977
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6360
7uUam
 41 45,6% 324 3.171E-107
2 phalp2_4279
86H4N
 25 26,5% 350 1.398E-22
3 phalp2_39046
8oXr6
 21 23,4% 371 1.308E-12

Domains

Domains [InterPro]
Phage_lys2
Ami5
Unannotated
Representative sequence (used for alignment): 7pnLO (475 AA)
Member sequence: A0A0P0I7S1 (324 AA)
1 475 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05382, PF18013

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage iA2
[NCBI] 		1739609 Iaduovirus > Iaduovirus iA2
Host Lactobacillus paracasei
[NCBI] 		1597 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus > Lactobacillus casei group

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KR905068 [NCBI]
CDS location
range 18079 -> 19053
strand +
CDS
ATGAGCATTCATGATTGGTTCGATCGTCACATCGGCACGATTACCTATAGTATGTATGGCTCTCGTAACGGTGCCGATGGGACAGCCGATTGTAGCGGATCCGTATCGCAGGCGCTAAAGGAGGCCGGCTATAACATTAGCGGATTGCCATCCACTGTGAGCTTAGGCAGTCAGCTGGCGGCTAACGGGTTCACACGTATCCATGTGTGGGCTGGTGGCGGAGATAACGGCTGGGATGTCAGCATGGACGACATCGTCCTGATGAGCTGGTCTTCGGCAGGCATGGCATATAGCGGTGGTGCTGGTGGGCACGTTGGTATCATTCACGATGACGCCGAAACATTCGAATCGTGTGACTACTGGACAGGCGGCCAAGCCAACACCGCGATCACGCGGCATGATGTGACGGCCTACATCAATAACTCCATCAGCAATGGCCTGCGGTATTATGAAGTGTGGCGCAAAGGTGGGTCGACCCCGTCCGCACCAGTACAAAACAATACTGCTGCGGTCAAAAAGGTCAACGTCACGTACGGCCTTAAGCTCAAGAATGGTGGCTGGTTAGATCCGGTCACCAATTTTGGTGCCGGCGATGAAGGTTTTGCAGGATTGCCAAACCACGCACACGACTTGCTTTACATTCGGGTAGATCATGGCGGCCTTCAGTATCGCGTCAGCACGTTAGAAGATGGCTGGCTCGACTGGGTTTACAAAGGTGATCCAAATGACACGGTTAATGGCTGTGCAGGCATTGTCGGTCACACGATTGACAAGGTGCAGATGATTTACCTGACACCGGCCGGTGAGCCGTATCAGCAAGCCTATTACCGCACACAAACAACGGCGCGGGAAAACTGGTTGGATGTTTGCTGTGATGATGGCACGTCAATCGCGTTGTACGACGGTTGGGCAGGGATGCCTGGCGAGCCACTCGATCGTTTGCAAATTGGCATCGGTTCTGTCAGCCCATTTTAA

Gene Ontology

No Gene Ontology terms available.

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000176a69b_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7pnLO) rather than this protein.
PDB ID
7pnLO
Method AlphaFoldv2
Resolution 88.53
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50