Protein

Protein accession
A0A0M7RDM5 [UniProt]
Representative
7BzuU
Source
UniProt (cluster: phalp2_36914)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVGVGLAINQPVHAAPHDLGTDVAKYQPQLTNNSGNDKFSIAQIGGSIHGWIYDQAPYSDQIYQGQNMGLRMHDYIWLETGADQAQTKVALEYFLKNIKTPYGSVVALDYEAGATDNVEANTANVVYGMQLVRQAGFTPMLYSYKPYLKAHINVNEVLKEFPNSLWIAGYQRSGNQPDYNCFPSMDGVAMWQFSDIPRDLDVDLTGITDNGYTKNTSVTPSNQPIAEPQPVKHDEPKQSTWKPVTYTVVNGDTLTAISNKTGDSVATIVANNDISNPNAIYIGQKLLVNHIKNGLIQKVRYVQPGDTLTRLSYLIGDSWETIVANNPDVFHGNMNATIFPGQPIYFYR
Physico‐chemical
properties
protein length:348 AA
molecular weight:38546,8 Da
isoelectric point:5,29
hydropathy:-0,36
Representative Protein Details
Accession
7BzuU
Protein name
7BzuU
Sequence length
364 AA
Molecular weight
41371,07180 Da
Isoelectric point
5,38222
Sequence
MTAAIVNYGGDYSKYQPSLYNNTGHDSFAISQIGGSVNGWIYEQATYSSHAQQAKSRGWRFHTYIWMQTGSNQSQTQQMLNYFLPRLQQPKGAIVALDYEDGASGNIEANTDNIIFGMRQIKNAGYTPMLYSYKPYMHDNVNVGRVLAVFPNSIWVAGYQPGLSITPNYGYFPSMDGVAIWQYSNYGGKQDLNVDLLGITWNGYRTTDGWQGSGDTWQYYENGSAVKNDWRKVDGKWYHFDNFGNAEVNWKQINNHWYYFNPNHDGTFAGAVTGWQTINGKKYYFDPENAWMLTGRQEIDGKLYAFGDDGALQEAIANQPDDIQPAKDETTVKLSAADRQAIENDLKPYIQNTVKDEISKLRRD
Other Proteins in cluster: phalp2_36914
Total (incl. this protein): 65 Avg length: 313,0 Avg pI: 4,71
Protein ID Length (AA) pI
7BzuU 364 5,38222
1HI06 338 4,63428
2aKjN 340 5,08615
2blIF 339 4,56073
2dhsx 252 4,87715
3kI7y 338 4,58687
5Mt8M 244 4,31200
5PdAb 338 4,55186
5YWe2 339 4,67685
5twcL 393 6,29983
61pp5 339 4,76171
63DUF 338 4,66525
67g1X 338 4,63592
6Yh48 338 4,66292
6ZWky 195 4,32700
6Zfu4 343 4,73164
6aD4Z 338 4,69055
6b1rE 338 4,58943
6c95w 338 4,71681
6e9Ss 292 4,07652
6kbXN 338 4,91932
6kqb5 292 4,70663
6nDtw 339 4,47655
6rX0j 338 4,84754
6segp 339 4,60932
6wg1Y 339 4,71038
7080x 234 4,55817
70IJO 174 4,39044
70p71 172 4,45097
715MC 233 4,49650
734WV 366 5,85182
76kvW 334 4,65150
7Og1k 343 4,76933
7RnzJ 354 4,64661
7UMYl 339 4,52037
7ZztX 338 4,74204
7Zzv9 338 4,65525
7uEiV 365 5,27661
7z83O 363 5,14043
81eix 340 4,96121
85sgG 340 4,88528
8bqrJ 314 4,76756
8mZuo 204 4,55141
BW3x 178 4,36423
CUp1 338 4,68117
D9Xd 350 4,31302
DRSy 340 4,83350
Exr1 190 4,36475
Exxi 318 4,52043
F0Ys 339 4,82145
F1JX 348 4,93171
KNe8 338 4,80388
KPNQ 252 4,52628
NKWG 240 4,48053
Nnw6 353 4,94172
Ns2S 338 4,67878
O3ML 340 4,80690
OQnO 338 4,57909
OkL1 334 4,69896
Oqfa 337 4,68435
oQUM 341 4,18809
oTlh 261 4,23532
qb31 268 4,68719
xmxZ 238 4,43028
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36076
6wAjV
 94 30,9% 297 3.160E-40
2 phalp2_38194
7g15T
 1 22,9% 309 6.364E-35
3 phalp2_36209
7jVrq
 19 27,8% 323 2.439E-33
4 phalp2_11124
5oePU
 31 28,5% 284 1.505E-32
5 phalp2_1050
734XP
 69 31,0% 251 9.264E-32
6 phalp2_33489
7w448
 5 20,8% 298 3.190E-28
7 phalp2_14685
6l3sC
 9 26,8% 264 8.656E-27
8 phalp2_39105
2miE5
 4 20,5% 370 5.684E-25
9 phalp2_14409
4y7ED
 4 19,0% 236 7.058E-06

Domains

Domains [InterPro]
GH25
Choline_bind_3
Disordered region
Representative sequence (used for alignment): 7BzuU (364 AA)
Member sequence: A0A0M7RDM5 (348 AA)
1 364 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF19127

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage EV3
[NCBI] 		980881 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
LN885237 [NCBI]
CDS location
range 21383 -> 22429
strand +
CDS
ATGGTTGGAGTTGGCTTAGCAATTAATCAACCAGTTCATGCTGCACCACACGATCTGGGAACTGACGTTGCTAAGTACCAACCGCAATTAACTAATAATTCGGGTAATGACAAGTTTTCAATTGCTCAAATTGGAGGCTCAATTCATGGCTGGATTTATGACCAAGCACCATATTCAGACCAAATTTATCAAGGTCAAAATATGGGATTAAGAATGCACGATTATATTTGGTTAGAAACAGGCGCAGACCAAGCGCAAACTAAAGTGGCGCTAGAATATTTTTTAAAAAATATTAAAACTCCGTATGGATCAGTTGTTGCCTTAGATTATGAAGCAGGTGCAACTGATAATGTTGAAGCCAATACTGCTAATGTTGTTTATGGAATGCAGTTAGTAAGACAAGCTGGGTTCACGCCTATGCTTTACTCTTATAAACCTTATCTGAAAGCTCACATCAATGTTAATGAAGTTTTAAAAGAATTTCCTAACTCACTTTGGATTGCTGGGTATCAACGTTCGGGTAATCAACCAGATTATAATTGCTTCCCTAGCATGGACGGTGTAGCAATGTGGCAATTCAGTGATATTCCACGTGATTTAGATGTTGATTTAACTGGCATTACTGATAATGGGTACACTAAAAATACAAGTGTCACTCCAAGTAATCAACCAATTGCCGAACCGCAACCAGTTAAGCATGACGAGCCAAAGCAATCAACTTGGAAGCCGGTTACTTATACTGTTGTAAATGGCGATACCTTAACGGCTATCAGTAATAAGACTGGTGATAGTGTAGCTACGATCGTGGCTAACAATGATATTAGCAATCCTAACGCAATTTACATCGGTCAAAAGCTACTGGTTAACCACATTAAAAATGGTTTAATCCAAAAAGTTCGCTACGTTCAACCAGGTGATACCTTAACCAGATTAAGTTATTTAATTGGGGATAGTTGGGAAACGATTGTTGCTAATAATCCAGATGTATTTCATGGAAATATGAACGCCACAATTTTCCCGGGACAACCAATTTATTTTTATCGTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0006beb810_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7BzuU) rather than this protein.
PDB ID
7BzuU
Method AlphaFoldv2
Resolution 89.75
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50