Protein

Protein accession
A0A3G1L3E6 [UniProt]
Representative
105gA
Source
UniProt (cluster: phalp2_27985)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MIPSEAITLIVKFEEFGAEAYPDPIHGWSVPTIGYGTTIYPDGRKVGVRDRITREEAAKYLDHHLNSKILPALHKIPSYERMFHMQVAALISFAYNLGENFYGGKNFASITRLCDRPDLWWNRDWVISQFIKYRAGAELGLGRRRYAEALTFCWEDPLYAYAEAYRKLNSVEDIRALMPEEEALKLRRSW
Physico‐chemical
properties
protein length:190 AA
molecular weight:22082,0 Da
isoelectric point:6,97
hydropathy:-0,35
Representative Protein Details
Accession
105gA
Protein name
105gA
Sequence length
249 AA
Molecular weight
27874,27090 Da
Isoelectric point
4,87459
Sequence
MMKLQQIFKTNTVIAFDEIANDSELSKQVQIRLIALKLLAPPADGVFGEASLSALKQFQSDTNCNEDGIGTRTAEKLIETKEVETTVDTNETDNVPEAAIILIKEFEGLFLKAYVDPLSGGKPITIGYGCTRKLDGSEWELGESITEDEANQLLAHQLQHSYIPSLSKIPCWEKLTDNQKSALISFGYNLGADFFGNPNFSTMTRVLREELWNEIEHAFLLYCNPGTSVHEGLLRRRKREAQLFLSDVK
Other Proteins in cluster: phalp2_27985
Total (incl. this protein): 2 Avg length: 219,5 Avg pI: 5,92
Protein ID Length (AA) pI
105gA 249 4,87459
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_3745
5wa2f
 396 54,1% 157 3.772E-51
2 phalp2_40377
3RTMs
 387 51,9% 152 1.933E-45
3 phalp2_33618
sz4d
 1 44,2% 156 4.893E-32
4 phalp2_24522
4Trwk
 1 34,6% 228 3.149E-31
5 phalp2_6830
8n5Jv
 121 37,5% 232 2.173E-26
6 phalp2_4451
31DIk
 4919 40,5% 158 2.587E-21
7 phalp2_4532
3QBcV
 9 41,2% 177 5.511E-20
8 phalp2_20664
7DMXE
 3 36,3% 154 1.015E-19
9 phalp2_34911
4lF8s
 21 36,6% 183 1.327E-17
10 phalp2_28113
7zmZV
 50 38,9% 154 4.469E-17

Domains

Domains [InterPro]
PG_1
GH24
Representative sequence (used for alignment): 105gA (249 AA)
Member sequence: A0A3G1L3E6 (190 AA)
1 249 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Synechococcus phage S-CBWM1
[NCBI] 		2053653 Aokuangvirus > Aokuangvirus SCBWM1
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG450654 [NCBI]
CDS location
range 22368 -> 22940
strand +
CDS
ATGATCCCCAGCGAAGCTATAACCCTCATCGTGAAGTTTGAGGAATTTGGGGCAGAGGCATATCCGGACCCCATTCATGGATGGTCTGTACCAACGATCGGGTACGGAACAACCATTTATCCGGACGGTAGGAAGGTTGGTGTACGGGACAGGATAACCAGGGAAGAGGCTGCCAAGTATCTAGACCATCATCTGAATTCCAAGATCCTTCCGGCACTACATAAAATTCCAAGTTATGAGCGGATGTTCCACATGCAGGTGGCCGCTCTGATCAGCTTTGCATATAACCTAGGGGAGAATTTCTATGGGGGGAAGAACTTCGCCTCTATCACCCGGCTGTGTGACCGTCCTGACTTGTGGTGGAATCGTGACTGGGTCATTAGCCAGTTTATCAAGTATAGGGCTGGGGCTGAGCTGGGCCTTGGGAGGCGGCGGTACGCAGAGGCGCTAACCTTCTGCTGGGAAGACCCCCTCTATGCCTACGCAGAAGCCTACAGAAAGCTAAACAGTGTAGAGGATATCCGTGCTCTTATGCCTGAGGAGGAAGCCCTCAAGCTCCGGAGGTCCTGGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (105gA) rather than this protein.
PDB ID
105gA
Method AlphaFoldv2
Resolution 88.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50