Protein

Protein accession
A0A2Z6BEJ9 [UniProt]
Representative
5oGmc
Source
UniProt (cluster: phalp2_144)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKLKTKLITLVVAFLAAISFALPSHVNAAKGDIGVDWAVYQGANGKYGTNDKFAIIQAGGTQGGTLYDQWTYASQVKAAQANGLKVHTYLWYGVGGSADIGRQALDYFLPKILTPKGSIVALDYEDGASSSMAANTDAILYGMRRIAQAGYTPMYYSYKPYTLAHVDYQRILAEFPNSLWIAAYPDYQIRALPDYGVFPSMPGIALYQFTSMHAAGGLDGNVDLLGVTDNGYSQQPVAPSKPATPSQPSTSTAASDTDYAQTGVFKPSTTVNIRTGAGTEYASVGSYAPGESVIYDHVYIRGTYVWARYLSYSGRYHYVALGVNGGESYGSRSSGYTSPVSHTYYTVRYGDSFWSIASKYGISMYTLAANNGKSIYSLIYPGESLYIR
Physico‐chemical
properties
protein length:388 AA
molecular weight:41988,5 Da
isoelectric point:8,30
hydropathy:-0,14
Representative Protein Details
Accession
5oGmc
Protein name
5oGmc
Sequence length
191 AA
Molecular weight
20467,28440 Da
Isoelectric point
7,82764
Sequence
MDGVAIWQYTSAFGLSQGLDGNIDLLGVTDNGYSKQPATPSVPVTPAPSQPAKSNAASDTDYAQNGVFKPSATVNIRTGAGTGYASVGSYAPGESVIYDHVYIRGTYVWARYLSYSGRYHYVALGVNGGESYGSRSSGYTSPVSHTYYTVRSGDSFWSIASKYSISMYTLAVNNGKSIYSLIYPGESLYIR
Other Proteins in cluster: phalp2_144
Total (incl. this protein): 8 Avg length: 274,1 Avg pI: 8,42
Protein ID Length (AA) pI
5oGmc 191 7,82764
6gabs 241 8,92283
78Tzy 145 9,99391
7RoCH 237 6,05559
7yJJQ 210 8,58482
A0A6M3BF03 388 8,77281
A0AAF0AQ69 393 8,89530
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25839
5j1l4
 12 78,5% 191 3.942E-92
2 phalp2_38217
7u45O
 5 35,8% 198 6.418E-30
3 phalp2_29108
6ZCjl
 6 33,0% 121 2.241E-14
4 phalp2_28052
75Rgb
 8 31,0% 190 4.052E-10
5 phalp2_15728
3kqKZ
 1 31,2% 195 1.545E-08

Domains

Domains [InterPro]
Disordered region
SH3_5
LysM
Representative sequence (used for alignment): 5oGmc (191 AA)
Member sequence: A0A2Z6BEJ9 (388 AA)
1 191 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF08460

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage T25
[NCBI] 		2036055 Sukhumvitvirus > Sukhumvitvirus T25
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AP018361 [NCBI]
CDS location
range 23430 -> 24596
strand -
CDS
ATGAAACTAAAAACTAAACTAATCACCTTGGTAGTCGCCTTCTTGGCGGCTATTTCTTTTGCCTTGCCATCGCATGTCAATGCGGCCAAGGGCGATATCGGTGTGGACTGGGCAGTTTATCAGGGAGCCAACGGGAAATATGGCACGAATGACAAGTTCGCGATCATTCAGGCTGGCGGTACACAAGGCGGTACGCTGTATGATCAATGGACGTATGCAAGCCAAGTCAAGGCAGCACAGGCGAATGGGCTCAAAGTCCACACTTATCTGTGGTACGGGGTCGGTGGCAGTGCTGATATTGGCCGACAGGCACTTGACTACTTCCTTCCCAAGATTCTAACGCCGAAAGGTTCTATTGTTGCTCTTGATTATGAGGACGGTGCCTCATCAAGTATGGCTGCCAATACCGATGCCATTCTATATGGTATGCGGCGCATTGCGCAGGCGGGATATACGCCAATGTATTACAGCTACAAGCCGTATACACTGGCACACGTTGACTATCAGCGCATTCTAGCGGAGTTTCCCAATTCACTGTGGATCGCGGCCTATCCGGACTATCAGATTCGGGCATTGCCAGATTATGGTGTATTCCCGTCAATGCCCGGCATTGCGCTCTACCAATTTACTTCTATGCATGCGGCAGGCGGTCTTGATGGCAACGTTGACTTGCTTGGCGTAACCGATAATGGATACAGTCAACAACCTGTCGCGCCATCAAAGCCCGCAACACCATCGCAACCGTCTACTTCAACAGCAGCCAGTGATACCGACTATGCGCAAACTGGTGTTTTCAAGCCGTCCACGACTGTTAACATCCGCACTGGTGCTGGTACAGAATATGCATCCGTTGGTAGCTACGCACCCGGTGAAAGTGTGATTTATGATCACGTGTATATCCGTGGCACATATGTTTGGGCACGTTATCTCAGCTACTCAGGCAGGTATCATTATGTTGCCTTGGGCGTGAATGGTGGGGAGAGCTATGGCTCGCGTTCGTCTGGATACACCTCACCAGTAAGCCACACGTACTACACAGTCCGCTATGGTGATAGCTTCTGGAGTATTGCCAGCAAGTATGGAATCAGTATGTACACACTGGCAGCCAACAACGGCAAGTCAATCTACAGCCTGATCTATCCGGGCGAAAGCCTGTATATTAGGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (5oGmc) rather than this protein.
PDB ID
5oGmc
Method AlphaFoldv2
Resolution 73.40
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50