Protein

Protein accession
A0A385UCI0 [UniProt]
Representative
7h6JD
Source
UniProt (cluster: phalp2_32230)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MADYFYPLSQGAHVTSPFGPRAGGYHWGTDYGRAGGSGGNAVYAPQAGTVIMAGPASGFGGPDPAGWIVIDHPTAAGGGVSVLGHIIREVAVGDTVRAGQRIGRVNPSSATNGGVAPHVHFEHHRYVWSPPGPDRLDPHAWLATRGARWPGAPATPTRKESMNALTADIDLLTPNDDGRATKPRNLLCIHTFEDDGTWSADRMAKYQQSPAAGGSYHLVIDLNGRIARENDDAFIPWAAMFTGNRVAFHFSLSGKASWTRQQWLARPKQMDALAKVLAAYSKAKGIPLIRRGPQDVRAGKWGVCGHDDISKAFGESTHWDPGPNFPFDVVIDKAKAILAEPKPTPAPPSDPAPRPIPPKETLVPTTLDTVLPSLVDGSTFEAPLATFIRTADKQAYEANQRIARLEAKFDRLLDAMGEKPDPKPGQ
Physico‐chemical
properties
protein length:426 AA
molecular weight:45651,9 Da
isoelectric point:8,40
hydropathy:-0,41
Representative Protein Details
Accession
7h6JD
Protein name
7h6JD
Sequence length
241 AA
Molecular weight
26961,88610 Da
Isoelectric point
5,43497
Sequence
MANAYICDMDLLTNNDSGTTSDPRRVLVVHTFEGRDLDAAAMARYQQQPSAGGSYHLVIDKDGTTARENDDEFMPWAAYPTGNRIGYHFSLAGQAAFTRDQWLNRPAQLTKLAEVLAAYSMAYGIPLIRRTAEGVRAGQWGVCGHAEISGAFHESDHTDPGVNFPYDHVLNLANGIVNDLKKGDTKVTNLLDEMITVWDKTRHKVRELIANIDSRTHIMFTETLPRIEQKLDQVLTEQEKN
Other Proteins in cluster: phalp2_32230
Total (incl. this protein): 19 Avg length: 256,1 Avg pI: 6,13
Protein ID Length (AA) pI
7h6JD 241 5,43497
1dat7 245 6,41419
3kVVa 240 5,58195
3tqpm 245 6,46705
4MKwF 283 4,97628
5irdT 245 6,09032
5yfkz 186 6,48450
6ELDa 245 6,41419
6U8C2 270 4,90966
6kBr3 240 6,06639
72xWg 263 9,06917
7XE0S 259 5,03317
7qzf6 268 5,30105
7ubdS 245 6,41419
7ujyC 244 5,95936
7ykjO 240 6,07384
8bEdX 240 5,35977
NU2K 240 5,98517
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8504
1jszc
 7 62,7% 180 2.983E-76
2 phalp2_18569
7cxQw
 45 38,5% 171 9.812E-54
3 phalp2_26201
8INhm
 9 34,8% 195 4.110E-46
4 phalp2_22201
6VaYI
 26 36,3% 190 2.936E-43
5 phalp2_184
5Dm5y
 192 31,9% 188 5.318E-40
6 phalp2_31178
7Vvn5
 47 35,2% 193 8.837E-39
7 phalp2_33007
4igcZ
 220 34,1% 164 7.854E-38
8 phalp2_17457
7PxDe
 7 32,0% 175 9.526E-37
9 phalp2_35315
7b5mp
 11 32,0% 243 1.233E-33
10 phalp2_18351
5t09q
 43 33,3% 150 5.845E-33

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 7h6JD (241 AA)
Member sequence: A0A385UCI0 (426 AA)
1 241 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Corynebacterium phage Juicebox
[NCBI] 		2301600 Juiceboxvirus > Juiceboxvirus juicebox
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH727550 [NCBI]
CDS location
range 21279 -> 22559
strand +
CDS
ATGGCCGACTACTTCTACCCACTCAGCCAGGGCGCTCACGTCACCAGCCCATTCGGGCCCCGAGCTGGCGGCTATCACTGGGGCACCGACTACGGCCGCGCCGGAGGCTCCGGCGGCAACGCCGTCTACGCCCCGCAAGCCGGAACCGTCATCATGGCCGGCCCCGCCAGCGGCTTCGGCGGCCCCGACCCCGCCGGATGGATCGTCATCGACCACCCAACCGCCGCCGGCGGCGGAGTCAGCGTCCTCGGCCACATCATCCGTGAAGTCGCCGTCGGCGACACCGTCCGCGCCGGGCAGCGCATCGGGCGGGTCAATCCTTCCTCGGCCACCAATGGCGGCGTGGCGCCGCACGTCCACTTCGAGCATCACCGTTACGTCTGGTCCCCGCCGGGACCGGACCGTCTGGACCCGCACGCTTGGCTGGCCACCCGCGGCGCCCGATGGCCGGGAGCCCCGGCCACACCTACCCGAAAGGAATCCATGAACGCGCTCACCGCTGACATCGACCTGCTGACCCCCAACGACGATGGCCGGGCGACGAAGCCCCGCAACCTTTTGTGCATCCATACCTTCGAAGACGACGGCACGTGGTCGGCCGACAGGATGGCGAAGTACCAGCAGTCGCCCGCCGCCGGCGGCTCGTACCACCTGGTCATTGACCTCAACGGCCGCATCGCTCGTGAGAACGACGACGCGTTCATCCCATGGGCGGCGATGTTCACGGGCAACCGGGTGGCGTTCCACTTCTCGCTGTCGGGCAAGGCGTCCTGGACGCGCCAGCAGTGGCTGGCCCGTCCGAAGCAGATGGACGCCCTGGCGAAGGTGCTGGCGGCGTACTCGAAGGCCAAGGGCATCCCGCTCATCCGCCGCGGACCGCAGGACGTGCGAGCCGGGAAGTGGGGCGTGTGCGGCCACGACGACATTTCCAAGGCATTCGGTGAGTCGACGCACTGGGACCCGGGCCCGAACTTCCCGTTCGACGTCGTCATCGACAAGGCCAAGGCGATCCTCGCCGAGCCGAAGCCGACGCCCGCCCCGCCGTCGGATCCGGCGCCCCGTCCGATTCCCCCGAAGGAGACTCTGGTGCCCACCACGCTCGACACCGTCCTGCCGTCGCTCGTCGACGGCTCCACGTTCGAGGCTCCGTTGGCCACGTTCATCCGCACCGCGGACAAACAGGCCTACGAAGCCAACCAGCGGATCGCCCGCCTGGAGGCGAAGTTCGATCGGCTGCTCGATGCCATGGGCGAAAAGCCCGACCCCAAGCCCGGCCAGTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7h6JD) rather than this protein.
PDB ID
7h6JD
Method AlphaFoldv2
Resolution 91.32
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50