Protein

Protein accession
V5YSX1 [UniProt]
Representative
4OkMH
Source
UniProt (cluster: phalp2_18221)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MRTSAHGIAVMHYFESCKLTAYPDPGSKDGRPWTIGWGHTGPEVVKGLVWTQAKADAVFVEDLRKFEQGVASLVKVPVTQGQFDSLVSFAYNVGLDIDTDTIAEGLGDSTLLRKLNARDYDGAALEFRKWTKNDGKVMRGLVRRRSAEEFLFRGMGGAESIAKGVKAA
Physico‐chemical
properties
protein length:168 AA
molecular weight:18382,7 Da
isoelectric point:8,66
hydropathy:-0,26
Representative Protein Details
Accession
4OkMH
Protein name
4OkMH
Sequence length
174 AA
Molecular weight
19116,30970 Da
Isoelectric point
4,56721
Sequence
MKTSDDGIALIKAFEGIRDGDPSTVNLDPYLCPADVATIGWGHAIVTPLGHQLRGRAGLNEARQMYPNGITIEEAEELLRLDLLERERAVESMVNVPLSQGQFDALVSFAFNVGTDIDEDDIPEGLGDSTLLRKLNAGDYQGAADEFLKWVYAGGRKLLGLERRRAAERELFLT
Other Proteins in cluster: phalp2_18221
Total (incl. this protein): 137 Avg length: 167,9 Avg pI: 8,27
Protein ID Length (AA) pI
4OkMH 174 4,56721
103En 174 8,69171
11ypR 203 9,71044
12CZ1 165 9,27934
14zSP 180 5,47782
191Iu 168 8,53234
1HMf8 168 10,03504
1I01M 165 9,60439
1J21j 146 9,05653
1J4kV 141 9,23834
1JK7M 163 9,40621
1Jzpw 168 8,96970
1KA7A 164 9,69638
1KAdY 164 9,54566
1KMHK 163 9,72410
1KQo2 164 9,56629
1LQpd 158 9,61470
1MBrg 164 9,41814
1MCgE 141 9,23834
1Q5M1 176 7,91783
1bdlF 173 9,80579
1dDfQ 173 9,80579
1jKKF 177 9,12777
1kQ7h 156 4,87380
1l7Bb 165 9,47190
1nJQ9 172 7,95219
1okYp 160 8,61641
1qvMl 142 9,53908
20B2p 168 9,41988
254G1 149 5,39302
2555k 150 4,99310
2CJJ 168 6,42573
2IFKT 164 9,47738
2JM5 203 8,74496
2SoWO 203 6,46847
2UDln 143 5,37773
2ctSs 183 5,57098
2j26t 163 9,41814
2twBm 166 9,48802
3Muc6 144 5,88166
3Ooyd 179 9,12068
3P8L4 166 6,88453
3PbQ8 166 6,35985
3SYTd 166 7,86606
3VTg 211 6,84014
3ZpXM 216 5,74201
3cyfd 165 9,38648
3dGcV 143 9,82429
3eMqT 153 8,57154
3emuO 151 9,83596
3fqEN 174 6,57521
3fsFF 167 9,31995
44SJA 175 9,36050
4BHPp 170 9,49453
4FFdR 164 9,49737
4Glia 168 8,61931
4I9Yx 186 5,17078
4IaFj 132 6,02149
4KJPt 164 9,47551
4KJTm 125 9,37101
4KJYT 164 9,45476
4KNi0 164 9,45476
4QHQN 175 9,25619
4UbA8 146 9,43187
4cC2j 144 4,83611
4dLTz 164 9,52142
4dNRE 154 5,38682
4eGFC 163 9,46952
4f7WG 145 9,54301
4g5Pw 143 9,02269
4gJFu 145 9,61116
4gJYZ 174 9,33530
4gJrL 166 9,11836
4kKtH 164 9,54011
4kRZH 168 9,29642
4kTVq 229 7,71234
5GCBk 133 5,69609
5IYQl 194 9,64565
5IhcI 132 5,62310
5JqA2 145 5,26422
5hOru 163 9,46894
5hUyO 152 9,85678
5iOf 147 5,18863
6HTWg 146 5,05278
6Kaqu 165 9,49253
6MWx5 153 6,97115
6PyoH 183 7,88353
6QNXK 143 6,16876
6TzEp 167 6,64189
6VCnQ 160 7,77896
6VHu4 159 8,79183
6VMAp 161 8,81439
6Wtnq 174 6,58562
6XC5K 203 5,05409
6yyMc 170 5,63658
72AEv 162 9,23705
7A0B1 211 9,74712
7BPJY 269 9,29468
7Cl6Q 175 5,64959
7FUOI 169 9,47526
7KxVJ 166 8,70911
7dA3n 146 10,00970
7pF6M 196 8,58843
7sukw 141 6,94359
7wdug 175 9,78367
7ydmb 178 8,99948
81fF5 166 8,77042
83YQf 178 8,92560
86TvR 147 4,86891
87t5N 164 9,11597
8Ac4K 189 6,84327
8BW1j 147 9,51213
8LF11 211 9,71128
8LpFX 212 8,97866
8LpV5 203 9,40589
8MWFw 212 9,19172
8MWLd 213 9,38745
8eKlf 175 9,25007
8hpgX 168 5,05716
8iPzZ 175 9,63282
8jTPM 204 9,66692
8jbU 157 9,41408
8jhLY 188 9,02733
8jo59 141 9,23834
8jwOh 191 6,51820
8m0RW 132 5,88593
8z4iF 147 9,47854
PTXq 148 8,43886
b4mp 167 8,89826
fDt2 176 8,32604
ffN 203 9,27592
hq2v 166 9,59485
mbPV 145 4,35014
unu2 145 9,60439
wH1Q 148 9,12635
A0AAX4QK48 197 9,68104
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28113
7zmZV
 50 50,0% 174 1.685E-58
2 phalp2_4451
31DIk
 4919 50,2% 175 3.942E-57
3 phalp2_2632
6RhYr
 14867 51,7% 172 9.223E-56
4 phalp2_33221
5jbqV
 447 48,5% 175 5.553E-54
5 phalp2_6830
8n5Jv
 121 48,2% 176 1.430E-53
6 phalp2_2498
5GMvl
 297 48,2% 174 6.912E-53
7 phalp2_17663
6R9yG
 6 50,8% 173 4.159E-51
8 phalp2_126
5jCCA
 637 46,2% 175 9.717E-50
9 phalp2_4532
3QBcV
 9 48,8% 170 3.427E-49
10 phalp2_37325
8t1Gv
 89 50,8% 173 4.696E-49

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 4OkMH (174 AA)
Member sequence: V5YSX1 (168 AA)
1 174 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudomonas phage PPpW-3
[NCBI] 		1279082 Hiroshimavirus > Hiroshimavirus PPpW3
Host Pseudomonas plecoglossicida
[NCBI] 		70775 Proteobacteria > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas > Pseudomonas putida group

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AB775548 [NCBI]
CDS location
range 42401 -> 42907
strand +
CDS
ATGAGAACTTCGGCGCACGGCATCGCCGTTATGCACTATTTCGAATCCTGCAAGCTGACTGCTTACCCTGACCCTGGCAGCAAGGATGGCCGGCCGTGGACTATCGGCTGGGGCCATACCGGGCCGGAAGTGGTCAAGGGTCTGGTGTGGACGCAGGCCAAGGCTGATGCGGTCTTTGTCGAGGACCTGCGCAAGTTCGAACAGGGCGTGGCTTCCCTGGTGAAAGTGCCGGTGACCCAGGGCCAGTTCGATTCCCTGGTTTCGTTCGCCTACAACGTCGGCCTGGATATCGACACCGACACCATCGCCGAAGGGCTGGGCGACAGCACACTGCTGCGCAAGCTGAATGCCCGCGACTATGACGGCGCTGCCCTGGAGTTCCGCAAGTGGACCAAGAACGACGGCAAGGTGATGCGCGGCCTGGTGCGTCGTCGGTCGGCTGAAGAATTCCTGTTCCGTGGCATGGGCGGCGCTGAGAGCATCGCCAAGGGAGTGAAAGCGGCATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
V5YSX1
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4OkMH) rather than this protein.
PDB ID
4OkMH
Method AlphaFoldv2
Resolution 92.56
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50