Protein

Protein accession
A0A4Y5TWP4 [UniProt]
Representative
2SpyY
Source
UniProt (cluster: phalp2_6942)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSRNKLVGSLLAGVIALAAGFEGVKYVAYQDVGNVWTYCYGETLGVKKGDTATPEQCKSQLIASLLRHNAPFEKLPRQLPANVHLAALDFCYNVGVGNCTNSTLWRHLQTGRYNEACQQFTRWRYAAGRDCSQAGSQCRGVWERRKLERDICAGAVSIEQAATRLGQKLEAPDNAKAN
Physico‐chemical
properties
protein length:178 AA
molecular weight:19583,0 Da
isoelectric point:9,07
hydropathy:-0,36
Representative Protein Details
Accession
2SpyY
Protein name
2SpyY
Sequence length
80 AA
Molecular weight
8649,68260 Da
Isoelectric point
7,99442
Sequence
VTGAKRVSLNTRVATMFGAISMLIAGVMATQQEGTRYVAYQDVGGTWTICEGDTHNVKQGDTATREQCDDRLRKNLIAAS
Other Proteins in cluster: phalp2_6942
Total (incl. this protein): 4 Avg length: 153,0 Avg pI: 8,72
Protein ID Length (AA) pI
2SpyY 80 7,99442
N0DSE8 177 8,90426
L0MZ33 177 8,91625
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24269
3bvr0
 10 39,2% 51 3.122E-09
2 phalp2_30282
4kWNQ
 1 39,3% 61 1.532E-08
3 phalp2_17749
7tNIh
 28 36,6% 71 7.519E-08
4 phalp2_6237
6y3FI
 8 38,8% 54 2.492E-06
5 phalp2_20985
7xCJE
 9 33,3% 63 3.426E-06

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 2SpyY (80 AA)
Member sequence: A0A4Y5TWP4 (178 AA)
1 80 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Aeromonas phage 2_D05
[NCBI] 		2588098 Kunmingvirus > Kunmingvirus kv2D05
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK804891 [NCBI]
CDS location
range 535 -> 1071
strand -
CDS
ATGAGTCGTAATAAACTGGTGGGCTCACTACTTGCCGGCGTCATAGCGCTGGCAGCGGGCTTTGAGGGGGTCAAGTACGTGGCGTACCAAGACGTTGGCAATGTGTGGACCTACTGCTACGGCGAGACCCTCGGCGTCAAGAAAGGCGACACAGCCACACCAGAACAGTGCAAATCGCAACTGATCGCCTCCCTGCTCCGTCACAACGCCCCGTTCGAGAAGTTGCCGCGCCAGCTCCCCGCGAATGTTCATCTCGCCGCGCTCGACTTCTGCTACAACGTCGGGGTTGGCAACTGCACCAACAGCACGCTGTGGCGCCACCTGCAGACCGGCCGGTACAACGAGGCATGCCAGCAGTTTACCCGCTGGCGCTACGCCGCCGGGCGCGACTGCTCGCAAGCTGGCAGCCAGTGCCGAGGGGTGTGGGAGCGCCGCAAGCTGGAGCGCGACATCTGCGCCGGGGCGGTGAGCATCGAGCAGGCAGCCACACGGCTAGGTCAAAAACTGGAGGCTCCGGACAATGCTAAAGCTAATTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2SpyY) rather than this protein.
PDB ID
2SpyY
Method AlphaFoldv2
Resolution 75.76
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50