Protein

Protein accession
A0A0E3T6C0 [UniProt]
Representative
1GW8q
Source
UniProt (cluster: phalp2_714)
Protein name
L-alanyl-D-glutamate peptidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MAYSLDDLLKKAQPKLEGVHPSVQACALQLITKAYAKGYKLIITQGLRTIAEQNKLYAKGRTTAQLRAVGITGIAGNPSAAIVTRAKGGTSYHNYGLAFDIGILRTDEKDVDWTDSKYRPIGALGKELGLEWGGDFKSIKDTPHYQLSFGLSIADLQAGKRPKGSTVSVHPGVQVVKLGSEGALVKDVQIKLNKLGFDCGDPDGIAGKKTVAAIEDFQAKFGLSKDGIAGRDTLAKLNELAAEKAEEVKEEAEKKDLPKVESFGGTPIRVTTITDAGVYAHADISGKSRTIKKGTTFRVYGNTYAAWAVNDGFVQMKDVEPQPMTIHTGGVNIAMQTELKRFMSGLNKDTVLIFKSEGGNPYAEITAKGLVLVEILRYLKANKWYYKEAPKA
Physico‐chemical
properties
protein length:392 AA
molecular weight:42370,1 Da
isoelectric point:9,26
hydropathy:-0,29
Representative Protein Details
Accession
1GW8q
Protein name
1GW8q
Sequence length
206 AA
Molecular weight
23386,51630 Da
Isoelectric point
9,26457
Sequence
VKTYAERLDTLHPILREKGLQLIDLCKKEGINILITQALRTIEEQDQLFAKGRTAPGKVVTNVRGGYSYHNYGLAFDFAIYDKDGRVNWTIDKNWHRVGALGKSLGLEWGGDWTKFKDYPHFQLTFGLTIEELRSGAKPVAPSLKKEELPMQKVDQTVSSWARESWQKAKLKGIVDGSNPKESLTRQEFAVILDRIGVLDSLKDKK
Other Proteins in cluster: phalp2_714
Total (incl. this protein): 36 Avg length: 274,7 Avg pI: 8,58
Protein ID Length (AA) pI
1GW8q 206 9,26457
4MDLH 218 4,98361
4SVNI 216 4,97400
4jOBS 209 9,04126
5imvA 222 9,49705
5iqbo 222 9,40976
6T7bn 206 9,99455
7dyBm 220 4,89119
7pt2V 224 5,31538
7pt7s 218 5,30435
7pt8y 221 5,44298
CAN4 205 5,19448
V4P1 206 5,01368
A0A0E3JT47 392 9,42981
A0A217EQM4 343 9,78000
S0A396 139 9,43181
U5PVY5 243 9,36147
A0A0C5AFG6 243 9,21655
A0A0A0RPZ6 243 9,21655
A0A0H4TGB9 243 9,21655
A0A7G5CGK7 343 9,89720
A0A7G5CH81 343 9,85627
A0A7T3KIJ0 343 9,80998
U5PW86 243 9,36147
U5PWC4 243 9,36147
U5Q083 392 9,38661
U5Q1E4 392 9,38661
A0A9Y1YTI1 341 9,80295
A0A9Y1YUA3 162 9,51884
A0A9Y1YUM4 343 9,80998
A0A9Y1YVH4 343 9,86864
A0A9Y2DZ13 343 9,86864
A0AAE9BML3 343 9,87283
A0AAF0BXJ8 340 9,85904
A0AAU8BCF7 343 9,82764
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8179
71Pzy
 8 49,6% 145 2.279E-63
2 phalp2_8235
7vUi0
 89 31,5% 285 2.279E-63
3 phalp2_26137
aKO9
 109 54,1% 146 9.174E-58
4 phalp2_1337
15l6q
 1516 52,2% 132 5.611E-50
5 phalp2_6580
1dlN9
 3 43,2% 141 5.611E-50
6 phalp2_35414
f7cN
 32 53,0% 132 9.558E-43
7 phalp2_34371
4aKCB
 348 47,4% 137 1.308E-42
8 phalp2_34998
4MASs
 7 42,7% 159 3.355E-42
9 phalp2_33807
1hNOs
 60 44,8% 147 6.285E-42
10 phalp2_15551
8jofz
 4 45,0% 140 8.602E-42

Domains

Domains [InterPro]
PET_M15
Unannotated
Representative sequence (used for alignment): 1GW8q (206 AA)
Member sequence: A0A0E3T6C0 (392 AA)
1 206 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF13539

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage Stills
[NCBI] 		1610833 Slashvirus > Slashvirus stills
Host Bacillus megaterium
[NCBI] 		1404 Firmicutes > Bacilli > Bacillales > Bacillaceae > Bacillus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KP696448 [NCBI]
CDS location
range 42687 -> 43865
strand +
CDS
ATGGCTTATTCATTAGATGATTTATTGAAGAAAGCGCAACCCAAATTAGAAGGTGTTCATCCATCGGTTCAGGCATGTGCTCTACAATTAATTACAAAAGCTTATGCTAAAGGTTATAAATTGATTATCACACAAGGACTTCGTACAATCGCTGAACAAAACAAGTTATATGCAAAGGGCCGCACAACAGCACAATTAAGAGCTGTAGGAATCACTGGAATCGCTGGTAATCCTTCTGCTGCAATTGTTACTCGTGCAAAAGGCGGTACATCTTATCATAACTACGGTTTAGCTTTTGACATCGGTATTTTACGAACAGATGAAAAAGATGTTGATTGGACTGATTCAAAATATCGTCCTATCGGTGCTTTAGGAAAGGAATTAGGTTTAGAATGGGGTGGAGATTTCAAATCAATTAAAGATACTCCACACTATCAATTATCTTTCGGCCTTTCTATTGCTGATCTTCAAGCCGGTAAACGTCCAAAAGGTTCAACTGTTTCTGTTCATCCAGGAGTTCAAGTTGTTAAATTGGGTTCTGAAGGCGCATTAGTTAAAGATGTACAAATCAAACTTAATAAATTAGGTTTTGATTGTGGTGATCCGGATGGAATCGCCGGTAAGAAAACTGTAGCTGCTATCGAAGACTTCCAGGCTAAATTTGGTCTTTCTAAAGATGGAATTGCTGGACGTGACACTTTAGCGAAACTAAACGAATTAGCTGCTGAAAAAGCTGAAGAAGTTAAAGAAGAAGCTGAAAAGAAAGATTTACCTAAAGTTGAATCGTTCGGCGGTACTCCAATTCGTGTAACTACTATCACTGATGCAGGAGTTTATGCACACGCTGACATTTCCGGAAAGTCTCGTACAATCAAAAAAGGTACAACTTTTAGAGTATATGGAAACACTTATGCAGCATGGGCCGTTAATGATGGTTTTGTTCAAATGAAAGATGTTGAACCTCAACCAATGACAATTCATACCGGCGGCGTTAACATCGCTATGCAAACTGAATTGAAGCGTTTTATGTCAGGTCTTAACAAAGATACTGTATTAATCTTCAAATCAGAAGGTGGTAATCCTTACGCTGAAATTACTGCTAAAGGCTTAGTTTTAGTTGAGATTCTTCGTTACCTAAAAGCTAACAAATGGTATTACAAAGAAGCTCCAAAAGCTTAA

Gene Ontology

Description Category Evidence (source)
GO:0008233 peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000618fb59_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1GW8q) rather than this protein.
PDB ID
1GW8q
Method AlphaFoldv2
Resolution 89.24
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50