Protein

Protein accession
Q6NDZ4 [UniProt]
Representative
2G2LQ
Source
UniProt (cluster: phalp2_9902)
Protein name
Peptidase M23 domain-containing protein
Lysin probability
95%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MNKILNLLLPILRLILNHEKLQKQSNNWNDSPIASKKTETLRSEIPIPETVEKPLFFHPVRIVSERVTSSYGYRTLNIDGKAVRQFHIGTDFGGSGPVYAVEDSIVVRALAADKKFPVRFAKRDGTWVDLIKAKEIPSDRAWTPYVILKGIHTGNEYKYKHVDPSVEVGAEITAGTEVGRSGNFGYSMGAHLHFEVWVNSKTVDPLKYLKSLELVK
Physico‐chemical
properties
protein length:216 AA
molecular weight:24328,7 Da
isoelectric point:9,35
hydropathy:-0,29
Representative Protein Details
Accession
2G2LQ
Protein name
2G2LQ
Sequence length
216 AA
Molecular weight
24217,44500 Da
Isoelectric point
9,35496
Sequence
MNKILNLLLPILRLILNHEKLQKKSNNWNDSPIASKKTETLRSEIPIPETSEEPNFFHPVRIVSERVTSPYGYRTLNIDGKAIRQFHIGTDFGGSGPVYAVEDSIVVKALAADKKHPVRFAKRGGTWVDLIKAKEIPSDRAWTPYVILKGIHTGNEYKYKHVDPSVEVGAEITGGTEVGRSGNFGYSMGAHLHFEVWKNSKTVDPVNFLKSLELVK
Other Proteins in cluster: phalp2_9902
Total (incl. this protein): 65 Avg length: 225,7 Avg pI: 9,40
Protein ID Length (AA) pI
2G2LQ 216 9,35496
1CeNQ 218 9,28469
5EkvO 245 9,17722
72BW0 229 9,51735
72Rbb 231 9,60271
72jaO 231 9,14898
730Xt 196 8,42043
739BN 196 8,42036
739qT 226 9,39454
73SI1 226 9,34419
73SVM 231 9,67820
73Ukh 180 9,70837
73Unl 226 9,28501
73VRO 226 9,60877
73VwG 226 9,41736
73ZSy 226 9,63585
73iRg 229 9,69677
74ZWo 229 9,30106
74aCU 231 9,61515
74g3R 226 9,35625
74g5r 231 9,58737
74gKF 229 9,51742
74gNN 229 9,20920
75F2o 231 9,14898
75i4q 228 9,39377
75prR 227 9,34039
75pte 229 9,28430
77Qjy 229 9,47880
7Skvl 226 9,61747
7Skwe 226 9,59020
7SlTn 231 9,62295
7i3pa 228 9,67691
7iH3O 231 9,25316
7iwyz 231 9,14898
7jn6V 229 9,47822
7jn9F 226 9,31454
7jnDv 226 9,50324
7jnbn 226 9,56828
7jngd 229 9,39409
7jnir 229 9,38565
7jnrx 229 9,47829
7lk5O 229 9,28430
7lk6x 231 9,16297
7lk92 231 9,58866
7lkF6 226 9,42568
7lkaV 226 9,42942
7lkfW 231 9,32898
7lknl 231 9,58466
7lkpu 226 9,69645
7lks9 226 9,20894
7lkyJ 229 9,57705
7lzyB 231 9,50246
7sWjh 226 9,61122
7tgOr 226 9,40357
7vE8V 229 8,89994
7voU3 216 9,43387
7xmjC 226 9,43335
8Ke8Y 231 9,68613
8Ke90 226 9,14879
8Ke9n 217 9,59020
8Ke9s 231 9,25316
8Ke9u 229 9,39409
8LMbr 216 9,35470
kMlG 223 9,66196
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_5933
67ENK
 29 36,4% 148 9.042E-21
2 phalp2_4014
134xF
 12 33,9% 153 2.284E-20
3 phalp2_40531
4Ht1U
 57 32,4% 145 3.669E-19
4 phalp2_36747
6BM9K
 381 30,0% 163 1.051E-13
5 phalp2_3247
2k2so
 54 27,5% 156 6.515E-13
6 phalp2_14848
7w0BH
 74 29,2% 157 2.193E-12
7 phalp2_5756
7Czmx
 45 28,6% 150 2.969E-12
8 phalp2_27996
15l2O
 11 31,4% 143 4.020E-12
9 phalp2_21998
4ZChj
 22 31,1% 167 4.020E-12
10 phalp2_19030
17y4D
 9 22,3% 206 5.442E-12

Domains

Domains [InterPro]
PET_M23
Representative sequence (used for alignment): 2G2LQ (216 AA)
Member sequence: Q6NDZ4 (216 AA)
1 216 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Leptospira phage LE1
[NCBI] 		137511 Saintgironsvirus > Saintgironsvirus LE1
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
BX571876 [NCBI]
CDS location
range 52742 -> 53392
strand +
CDS
ATGAATAAAATATTAAATTTACTTCTGCCAATTTTAAGATTAATCCTTAATCACGAAAAATTACAGAAACAATCAAATAATTGGAACGACTCCCCTATCGCTTCAAAGAAAACTGAGACATTACGATCTGAGATTCCAATCCCAGAAACCGTTGAGAAACCGTTATTTTTCCATCCAGTTCGAATTGTATCGGAAAGAGTTACATCATCTTATGGATATCGAACTTTGAACATCGATGGGAAAGCAGTAAGACAGTTTCACATAGGAACTGATTTCGGAGGTTCTGGACCGGTATATGCTGTGGAAGATTCGATTGTCGTGAGGGCTTTGGCGGCCGACAAAAAATTTCCGGTTAGATTTGCGAAACGCGATGGAACCTGGGTAGATCTTATCAAAGCAAAGGAAATCCCATCCGATCGTGCATGGACTCCATATGTGATTTTGAAAGGAATCCATACAGGGAATGAATACAAATACAAACACGTTGATCCATCTGTCGAAGTAGGCGCTGAGATAACAGCGGGTACTGAAGTCGGCAGGAGTGGGAATTTTGGATATTCAATGGGAGCTCATTTACACTTTGAAGTATGGGTAAATTCAAAGACAGTCGATCCACTGAAATATTTAAAATCCCTGGAACTAGTAAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000023205b_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2G2LQ) rather than this protein.
PDB ID
2G2LQ
Method AlphaFoldv2
Resolution 85.27
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50