Protein

Protein accession
A0A5P8PRF3 [UniProt]
Representative
8xARZ
Source
UniProt (cluster: phalp2_17800)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 95% (predicted by ML model)
Protein sequence
MPKASIGDTLMKHLLALLEYEESYREKAYYCSAGYPTIGIGKKIGPKAAPLHFYQFTCSKELAYLWLDEEVAKVQLQLVKYDWYNKQSDDRKTILISMAYQMGVEGLLKFRKMIAALKAGNFYEARMQALDSKWYRDTPLRAKRHAQVLETGDLLITYNGLLG
Physico‐chemical
properties
protein length:163 AA
molecular weight:18744,6 Da
isoelectric point:9,05
hydropathy:-0,29
Representative Protein Details
Accession
8xARZ
Protein name
8xARZ
Sequence length
243 AA
Molecular weight
27659,76910 Da
Isoelectric point
9,04828
Sequence
mnyverkrkeiktayaiiltlfvafcfafgaliadtqavefkvepkvnldpvlklntdkiclnynctkyavpviipttlspleqhwnsltsklvtvleseegfrsnpylgpegfihvgfgtklhnkkgllpkdfpikisrelatewlhsevaikdlrmsqgkyadiyskldeekqavilsmsyqlgtsgvkrfkkmwaalevgdydtaavemldsrwarqtpqraarhvrimkgsdidyvysk
Other Proteins in cluster: phalp2_17800
Total (incl. this protein): 6 Avg length: 168,2 Avg pI: 8,11
Protein ID Length (AA) pI
8xARZ 243 9,04828
H9C148 154 6,29642
A0A2I7R771 145 9,51336
A0A9P0VF73 152 8,43686
A0A9Y1HTV0 152 6,30193
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24334
3Qw2p
 463 31,4% 159 2.938E-25
2 phalp2_16834
1uDRT
 24 32,6% 147 2.546E-24
3 phalp2_17399
4Mm73
 7 26,6% 169 2.200E-23
4 phalp2_7697
6I6lz
 232 29,4% 156 4.072E-23
5 phalp2_32005
5iHOn
 21 29,7% 168 2.578E-22
6 phalp2_24213
2KXlJ
 83 32,9% 155 3.505E-22
7 phalp2_35438
8DSMF
 6 33,3% 150 8.522E-18
8 phalp2_33457
7eghX
 14 30,5% 154 3.271E-16
9 phalp2_3146
81Qco
 2 25,3% 158 6.753E-15
10 phalp2_35882
4PmGA
 1 25,2% 174 6.753E-15

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 8xARZ (243 AA)
Member sequence: A0A5P8PRF3 (163 AA)
1 243 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Vibrio phage phi50-12
[NCBI] 		2654972 Schitoviridae > Penintadodekavirus > Penintadodekavirus 5012
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MN584918 [NCBI]
CDS location
range 56862 -> 57353
strand +
CDS
ATGCCGAAGGCATCTATTGGAGATACACTAATGAAACATTTATTAGCATTATTAGAATATGAAGAAAGCTACAGAGAGAAAGCTTATTACTGTAGTGCCGGTTACCCTACCATTGGTATCGGTAAGAAGATTGGTCCTAAAGCAGCTCCTCTGCACTTCTATCAGTTCACTTGTTCAAAAGAGCTAGCTTACCTCTGGTTAGACGAGGAAGTAGCTAAGGTTCAACTACAGCTCGTTAAATACGACTGGTATAACAAGCAGTCTGATGATCGTAAAACCATCCTTATCAGCATGGCTTATCAAATGGGTGTAGAAGGCTTACTAAAGTTCCGTAAGATGATTGCTGCTCTTAAAGCAGGGAACTTCTATGAGGCTCGTATGCAGGCTTTAGATAGCAAATGGTATCGTGATACTCCCCTACGAGCTAAACGTCATGCACAGGTCTTAGAGACTGGTGATTTGCTTATCACTTATAACGGATTACTGGGGTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8xARZ) rather than this protein.
PDB ID
8xARZ
Method AlphaFoldv2
Resolution 76.03
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50