Protein

Protein accession
A0A075KJD2 [UniProt]
Representative
8nhz5
Source
UniProt (cluster: phalp2_21498)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MANYDLVADVSSYQPDSEEFFQALKNKGVKAVIIKLTEGSNPGTAYVNPKAGSQIKNARSAGLKVHAYHYAKFNGVADAQAEADWFVKNAKKLGIGEDSVMVLDYEDHATARVNGTADINAFIQRVKNAGYPKTDIYSMRSWFEDGHIDRKKIIPKNIWLAEYGTGKPGLDDVGTWQFTSEYPVGGVKIDMSYDFKGLYTKGSQSSKKPTATNTKKKDHAGVWRSEKGTFTLELAIYLKTAPSKNAVSISLLKAGSKINYDAYAIQGGYVWIRQPRSNGYGYMATGYAKNGKRLDYWGKFS
Physico‐chemical
properties
protein length:301 AA
molecular weight:33300,2 Da
isoelectric point:9,42
hydropathy:-0,54
Representative Protein Details
Accession
8nhz5
Protein name
8nhz5
Sequence length
165 AA
Molecular weight
18587,70420 Da
Isoelectric point
9,12442
Sequence
MGLLVHGYHYARFNGNQDARNEAKWFVDHAKQFGLGPESVLALDIEDKANAKYATSDANAFLQAVKDAGYPKIDIYSMASWFWQGRLNAAQLIAKNKWVANYGVSQPGVDNVGLWQFTNTYNIAGNEVDMSYDFSGFILTPALRQSLRRLSTRQRLSQSLYLRLG
Other Proteins in cluster: phalp2_21498
Total (incl. this protein): 8 Avg length: 285,6 Avg pI: 9,32
Protein ID Length (AA) pI
8nhz5 165 9,12442
A0A075KJI2 300 9,32008
F8J1A5 301 9,51039
U3PJ04 301 9,46539
A0A2P1CCE6 301 9,36553
A0A075KQK4 300 9,46526
A0A8S5S759 316 8,92205
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32681
81Xxy
 1 38,3% 112 1.186E-15
2 phalp2_6251
6F8cA
 2 27,5% 120 6.192E-07
3 phalp2_5668
4yhqW
 7 28,1% 128 1.294E-05
4 phalp2_39219
3xEyz
 21 33,3% 111 5.868E-05
5 phalp2_20117
23DDy
 70 33,7% 148 5.868E-05
6 phalp2_22092
5WvnN
 1 28,6% 143 1.073E-04
7 phalp2_24174
2ojoF
 57 25,1% 147 6.515E-04

Domains

Domains [InterPro]
GH25
Disordered region
Representative sequence (used for alignment): 8nhz5 (165 AA)
Member sequence: A0A075KJD2 (301 AA)
1 165 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage Ld25A
[NCBI] 		1500734 Cequinquevirus > Cequinquevirus Ld25A
Host Lactobacillus delbrueckii
[NCBI] 		1584 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KJ564036 [NCBI]
CDS location
range 31419 -> 32324
strand +
CDS
TTGGCTAATTACGATTTAGTTGCTGACGTTTCAAGTTATCAACCAGACAGTGAAGAGTTTTTTCAAGCGTTGAAGAACAAGGGCGTTAAGGCAGTGATTATCAAACTGACGGAGGGATCTAATCCGGGAACGGCTTACGTTAATCCAAAAGCTGGTAGCCAAATCAAGAATGCACGGTCGGCAGGATTAAAAGTGCACGCTTACCATTATGCTAAATTTAATGGAGTAGCTGACGCACAAGCTGAGGCTGATTGGTTCGTTAAGAATGCTAAGAAGTTAGGTATTGGCGAAGATTCAGTTATGGTTCTCGATTATGAGGATCACGCAACAGCTAGAGTAAATGGGACTGCTGACATTAACGCCTTTATTCAAAGAGTAAAGAATGCAGGCTATCCTAAGACTGACATCTACTCAATGCGGTCATGGTTTGAGGACGGTCATATTGATCGCAAGAAGATCATTCCTAAAAACATTTGGTTAGCTGAATACGGTACTGGCAAACCAGGTCTTGATGATGTAGGCACTTGGCAATTTACTAGCGAGTATCCAGTCGGTGGGGTTAAGATAGACATGAGCTACGACTTCAAAGGGTTGTATACCAAGGGTAGTCAAAGCTCAAAGAAGCCTACTGCTACTAACACTAAGAAGAAGGATCATGCTGGAGTATGGCGCTCAGAAAAAGGAACGTTCACGTTAGAGCTGGCTATTTATTTAAAAACAGCACCAAGCAAAAACGCAGTTTCTATTTCATTGTTAAAGGCAGGAAGCAAGATCAACTATGACGCTTATGCTATTCAAGGAGGATACGTCTGGATTCGGCAACCGAGATCCAATGGCTATGGATACATGGCAACAGGATATGCTAAGAATGGCAAGCGGCTAGATTATTGGGGAAAATTCAGTTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8nhz5) rather than this protein.
PDB ID
8nhz5
Method AlphaFoldv2
Resolution 85.07
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50