Protein

Protein accession
V9VHX3 [UniProt]
Representative
7uUam
Source
UniProt (cluster: phalp2_6360)
Protein name
Putative endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTNYDKTFMLGAGQGSSQKTSNEYIIIHDTANDNNQGDNSAYNEASYMHNNWQNAYTHAIAGWDRVYLVGEAGYVAYGAGNVANSRAPFQIELSHYSDPVKQRQSYVNYVNAIREYANKFGIPLTLDGGGKGIKSHKWVSDNIWGDHQDPYGYLARIGISKNQLANDLAHGVGGTAPAPAPKPASAPAPKPKPKPSKPAQKVQTNVVYGLHQKGGGWLGEITNFNNSNSSGFAGLPSNKHDLLYMRVTHGSLKYRVHTIEDGWLGWVTNGNKNDTVNGCAGISGHTIDGVQAYFYTPSGEVYQQAHYRSQTAKRAGWLAPVVDDSDFAGIFGEPLDRLQVAISNTNPF
Physico‐chemical
properties
protein length:348 AA
molecular weight:37883,4 Da
isoelectric point:7,82
hydropathy:-0,59
Representative Protein Details
Accession
7uUam
Protein name
7uUam
Sequence length
298 AA
Molecular weight
33099,39870 Da
Isoelectric point
5,12627
Sequence
MDIDAAINALKKKIGKSTYSMEGSRDFSDGTCDCSGAVYYGLRKAGCSDFGYIPSTETLHEYLVQNGITLKAENEPFNMEKGDIIIWGKQGQSAGANGHTGICIDNQNWIECTAWHDLGETIQNHDKRWVMAGKPFFYVYHYTGRTPGINPNVTYGLHVKGGDWLSPVVNFNPVNSDGYAGLPNHEHDMLYARVDHGALKYRVHTIEAGWLDWVTSGNPNDPVNGCAGMFGQTIDGVQMVYLTPSGEYYRNAYYRSQTTKRADWLPEVADDSDFAGIFGEPLDRLQAAVNIRDPFGEQ
Other Proteins in cluster: phalp2_6360
Total (incl. this protein): 41 Avg length: 298,8 Avg pI: 6,04
Protein ID Length (AA) pI
7uUam 298 5,12627
11u14 276 4,97321
1Ianv 276 4,67554
5C2Pt 314 6,48825
5HEmn 301 5,27383
5P5WS 276 4,58062
5Ulf6 276 4,59591
5oGje 314 5,06665
5tDs1 296 5,26167
5tRAl 230 5,42008
5tXJq 314 4,94104
6ql1A 276 4,67554
72dUJ 316 5,03744
72w3v 296 5,39052
752V1 324 4,88715
76Z1L 316 5,12861
7d3Mj 238 9,13196
7d3Ng 244 9,21487
7dFKA 316 5,44543
7dd4z 238 9,01128
7hSKt 296 5,40047
7hgJ1 244 9,17825
7iNop 297 6,42669
7pewW 246 8,47200
7prUp 280 9,26999
7wURJ 316 5,62265
7wzjA 316 5,25075
83VAh 315 5,09803
83vGx 316 5,16117
8MvSc 316 5,12639
8kwbw 276 4,72732
ClRr 276 4,63774
D9hq 276 4,68844
E0YIU2 343 6,52474
A0A0D3MSS4 352 7,80888
A6MAD8 347 5,91185
A0A1W6JJH0 344 6,66428
A0A1W6JKF0 348 6,48797
A0A649V269 348 7,81906
A0A2D1GPD8 316 5,12639
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_6348
7pnLO
 8 42,5% 320 5.326E-117
2 phalp2_1575
7UZBp
 94 27,9% 254 1.035E-13
3 phalp2_7217
3nY5F
 15 28,6% 213 6.028E-13
4 phalp2_34501
4L3is
 112 27,0% 285 8.080E-13
5 phalp2_29519
21Fz5
 10 22,5% 248 2.085E-08
6 phalp2_23831
1lyS1
 37 25,2% 222 6.577E-08
7 phalp2_34343
3WHp5
 2 25,7% 237 2.644E-05
8 phalp2_6363
7w9Kz
 1 23,3% 312 6.199E-05

Domains

Domains [InterPro]
Ami5
Unannotated
Representative sequence (used for alignment): 7uUam (298 AA)
Member sequence: V9VHX3 (348 AA)
1 298 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05382

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactococcus phage phiL47
[NCBI] 		1412875 Audreyjarvisvirus > Audreyjarvisvirus L47
Host Lactococcus lactis subsp. cremoris
[NCBI] 		1359 Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus > Lactococcus lactis

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KF926093 [NCBI]
CDS location
range 30662 -> 31708
strand +
CDS
ATGACAAACTATGACAAAACCTTTATGCTTGGTGCAGGTCAAGGCTCATCTCAAAAAACAAGTAATGAATATATTATCATTCATGATACAGCTAATGACAACAATCAAGGAGACAATAGTGCATATAACGAAGCTAGCTATATGCACAACAACTGGCAAAATGCATACACACATGCAATTGCTGGGTGGGATAGAGTATATTTGGTAGGAGAAGCTGGATATGTTGCTTACGGTGCTGGTAATGTAGCAAACAGTCGTGCGCCTTTCCAAATTGAATTATCACATTATTCAGACCCAGTTAAACAAAGACAATCTTATGTTAACTACGTAAATGCTATTCGTGAATATGCAAATAAATTTGGTATTCCATTGACACTTGATGGTGGAGGAAAAGGTATCAAATCTCATAAATGGGTATCTGATAATATTTGGGGAGACCATCAAGACCCTTACGGTTACTTGGCACGTATTGGCATTTCAAAAAACCAATTGGCTAACGACTTGGCTCATGGCGTAGGTGGAACAGCTCCTGCTCCAGCACCAAAACCAGCATCAGCCCCTGCTCCAAAACCAAAACCAAAACCAAGCAAACCTGCTCAAAAGGTACAAACTAATGTAGTATATGGATTGCATCAAAAAGGTGGAGGTTGGTTAGGAGAAATCACTAACTTCAACAACAGTAACTCTAGTGGTTTTGCTGGGTTACCAAGTAATAAACATGACTTGCTCTATATGCGAGTAACTCATGGTTCATTAAAATATCGAGTACACACTATCGAAGATGGATGGCTCGGTTGGGTAACAAATGGTAATAAGAATGATACTGTTAATGGATGTGCTGGTATTTCTGGTCACACTATTGATGGCGTACAAGCTTATTTCTACACACCTAGTGGTGAAGTATATCAACAAGCTCATTATCGGTCACAAACCGCTAAACGTGCAGGTTGGTTAGCTCCAGTAGTTGACGATTCAGACTTTGCAGGTATCTTTGGAGAACCTTTAGATAGATTGCAAGTAGCAATTAGTAATACAAACCCATTCTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7uUam) rather than this protein.
PDB ID
7uUam
Method AlphaFoldv2
Resolution 92.83
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50