Protein

Protein accession
G1D5A2 [UniProt]
Representative
7u9Qz
Source
UniProt (cluster: phalp2_36228)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSFTKFLYDDPLITREQAMKVLIQVADELDMPDKKGACIIAGMTVSQEAGVEDGDAPFERRFWCPANPADPESFNYAHDSESNDGRSVGYFQQQKGPKGELWWGTTQSEMDLHSAATQFMTRLKKVGYNASNADAANNSAQSVQQSGVPWAYAQWWGDINQLYAKVAGTAPVAVPEGRFFEEINLIDGSGSQSRNGKKPRLIVLHTEEGNMAGQALDEWMDRNNVSYHYIIGNDNRAWDLVDTDRASWSVLDANNFCINYVFAPSYAGWTRQQWLDNMGTGIKICAYLVAQDCLKYNIEPVIRVGNSATGYASLPNSSGITDHYGITKGLGIGTHTDVGGGFPWDVFNTYLQKYLAGDTEDDMFTDTDRAMVQRIFFELTNKWESRSIYREPGEGPVDTLVGMLLNDDGMEHSELIERLAVLGDSDAIRRVRRSAAGKGAVTDKATVARAKKVFQSIPEEIMAAYKEEVGE
Physico‐chemical
properties
protein length:471 AA
molecular weight:52273,7 Da
isoelectric point:4,78
hydropathy:-0,45
Representative Protein Details
Accession
7u9Qz
Protein name
7u9Qz
Sequence length
477 AA
Molecular weight
51858,78340 Da
Isoelectric point
4,63990
Sequence
MSFTQFLQDDPLLAREQIMAIAIDVAKTLGMPDVKGAAILNVMAVSVEVGVEDNDPPHARRFWCPANHNDGDSFNYSHDSVSNDNRSIGYLQQQKGPNGELWWGTTAQQMDPHQAFISFQTRLKKRGYDASNAQSAGEAAQAIQGSAFPDRYREQWDDINALYDAVAGTITAPTTPTQPSFSFTEKNIIDGENASNRQGHNPRLFVLHTEEGNLLGQALDNWMDNNEVSYHYAVDPDASGAVAWDLVDTDLSSWSVLSANPDSINLVFAGSYAAMSRTDWLSKYGKAIKVAAYLAVQDCRKYGIETTVRVGFAAGGYSSLKTSNGITDHYGITKGLGIGTHTDVGPNFPWDVFASYVAQFANGTTEEDDMFTDADRALLTRVHFELTNKWNSRSIYAEPGEGPVDTLAGMVLNDDGMEHSELVERLAVLGDPDSLRRVIRVAAGEGVVTDAATVARAAKILAEVPADILTAYEAAAK
Other Proteins in cluster: phalp2_36228
Total (incl. this protein): 32 Avg length: 469,7 Avg pI: 5,04
Protein ID Length (AA) pI
7u9Qz 477 4,63990
6TiDx 449 4,53879
7AvGh 483 5,58616
7Axf9 471 4,71919
7AxrC 471 4,74193
7pJEn 447 4,82889
7pPWy 447 4,91074
7pUYf 447 4,91728
7q41m 448 4,91654
7qdVu 450 4,95587
7ud1c 442 4,76864
8KwGT 471 4,78405
8M5j1 455 5,22120
8MPYC 455 4,81735
A0A1W6JSI5 471 4,71919
A0A222YWG6 471 4,74193
A0A0M5M0S0 552 5,61589
Q9ZX49 547 5,55427
A0A0M5M0S9 455 5,22120
A0A7G8LHX3 455 4,81735
A0A3G2KDX8 552 5,61589
A0A7G9A2B1 471 4,69185
R4JD41 547 5,55427
A0A899IRK3 455 5,34681
A0A899IUX8 448 4,88215
A0A899J0T4 447 4,89085
A0AA51BLQ4 455 5,29071
A0AA96H5S8 455 5,29071
A0AA96HIR8 455 5,29071
A0AA96HMI0 455 5,29071
A0AA96KPJ2 455 5,29071
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_30754
7C7wA
 28 46,4% 377 4.621E-115
2 phalp2_39054
7o3xD
 152 45,0% 315 8.129E-91
3 phalp2_40628
7RbAk
 146 27,6% 531 3.358E-60
4 phalp2_6665
1IZIA
 9 27,5% 417 1.814E-41
5 phalp2_21200
16iHg
 24 23,4% 294 7.953E-14
6 phalp2_24325
3OISx
 4 21,9% 378 8.280E-10

Domains

Domains [InterPro]
Unannotated
Ami2
Unannotated
Representative sequence (used for alignment): 7u9Qz (477 AA)
Member sequence: G1D5A2 (471 AA)
1 477 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage Rey
[NCBI] 		1034115 Vilmaviridae > Reyvirus > Reyvirus rey
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JF937105 [NCBI]
CDS location
range 31173 -> 32588
strand +
CDS
TTGAGCTTCACCAAGTTTCTCTATGACGATCCGCTGATCACTCGCGAGCAGGCGATGAAGGTGCTGATCCAGGTCGCCGACGAGCTGGACATGCCCGACAAGAAGGGTGCCTGCATCATCGCGGGCATGACGGTCTCCCAGGAGGCCGGTGTCGAGGACGGCGATGCACCGTTCGAGCGCCGCTTCTGGTGTCCCGCCAACCCCGCTGATCCCGAGTCGTTCAACTACGCGCACGACTCCGAGTCCAACGATGGCCGCTCGGTTGGCTACTTCCAGCAGCAGAAGGGTCCGAAGGGCGAGCTGTGGTGGGGGACCACCCAGTCGGAGATGGATCTGCATTCTGCTGCAACGCAGTTCATGACCCGTCTCAAGAAGGTCGGCTACAACGCATCGAACGCTGACGCGGCGAACAACTCGGCGCAGTCGGTGCAGCAGTCGGGTGTGCCGTGGGCGTACGCCCAGTGGTGGGGCGACATCAACCAGCTGTACGCCAAGGTGGCCGGTACTGCACCTGTGGCCGTGCCCGAGGGCCGGTTCTTCGAAGAGATCAACCTGATCGACGGCAGCGGCTCGCAGTCGCGCAACGGCAAGAAGCCACGCCTGATCGTCCTCCACACCGAGGAGGGCAACATGGCTGGCCAGGCCCTGGACGAGTGGATGGACCGCAACAACGTGTCCTACCACTACATCATCGGGAACGACAACCGCGCATGGGATCTCGTTGATACCGACCGGGCCTCGTGGTCGGTTCTAGATGCGAACAACTTCTGCATCAACTACGTGTTCGCGCCGTCGTACGCGGGATGGACCCGCCAGCAGTGGCTGGACAACATGGGCACCGGCATCAAGATCTGCGCCTACCTGGTTGCTCAGGACTGCCTGAAGTACAACATCGAACCCGTTATCCGCGTGGGCAATTCGGCCACCGGTTACGCGAGCCTGCCGAACAGCAGCGGCATCACCGATCACTACGGGATCACCAAGGGCCTCGGCATCGGCACTCACACCGATGTCGGCGGCGGATTCCCGTGGGACGTATTCAACACCTACCTGCAGAAGTACCTCGCAGGCGACACGGAGGACGACATGTTCACTGACACTGACCGCGCCATGGTGCAGCGGATCTTCTTCGAGCTGACCAACAAGTGGGAGTCCCGCTCGATCTACCGCGAGCCGGGGGAGGGACCGGTCGACACCCTCGTGGGCATGCTGCTCAACGACGACGGCATGGAGCACAGCGAGCTGATCGAACGCCTTGCGGTGCTGGGTGATTCGGATGCCATTCGTCGCGTACGCCGGTCGGCTGCGGGCAAGGGTGCGGTGACCGACAAGGCCACTGTCGCTCGGGCGAAGAAGGTCTTCCAGTCGATCCCCGAGGAGATCATGGCCGCATACAAGGAAGAGGTAGGCGAGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000218e3ac_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7u9Qz) rather than this protein.
PDB ID
7u9Qz
Method AlphaFoldv2
Resolution 87.18
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50