Protein

Protein accession
A0A221J6E1 [UniProt]
Representative
7w7ps
Source
UniProt (cluster: phalp2_36900)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVLPITGINEQFNAAFFTAGPTEKDGIVIHWWGLPQGQGIDSVRTTFGNGGRQASAHFGATDGEVDCYVNPDDVAWANGNWAANLSKISIECNPRQSDGDYYAAAWTIAYIRSIYGDLPLSRHWDYYPTQCCGTYDLERLDQLAYDIAATGIWNSYQLPTPAAPVVPAPPAPATQAKSIDQLAQEVIAGAYGTGDARRVALGGQYDAVQARVNEILTGVSNAKPQPSISELADRVMRGEFGNGDQRITALGNQYQEVQNEINRRAGISAPVSVPSAPNIEDLVRRTLAGEFGNGDDRVRALGANYTAVQAEINRRYA
Physico‐chemical
properties
protein length:317 AA
molecular weight:34255,5 Da
isoelectric point:4,75
hydropathy:-0,35
Representative Protein Details
Accession
7w7ps
Protein name
7w7ps
Sequence length
297 AA
Molecular weight
31876,22360 Da
Isoelectric point
5,20312
Sequence
MAFQMLTQYNAKNFTPGPRKVTGITIHWWGDPVGQTFEGIIDWFCNPNSSVTTSAHYVAEAGRVACIVSPDDIAWHAGDWNANVANIGIECNPRATDADYQTIGELVAYLRGIYGDVPLYPHKHWTQTTCPGAYDVNRIDAIARGAKPQAAVAPQSSNTKPIQQEDDLTPEQAAQLAYIASPQFKADIFTGKSAVEVAAQNAYIDRILTRDFPWYGFDGKVPASGRKTTTVATDTGWADSRATGNTAVIGAKLDALMAVVAKGANVDVATLKQTVEDAVKASFGDYTVTIAKADSNG
Other Proteins in cluster: phalp2_36900
Total (incl. this protein): 19 Avg length: 311,3 Avg pI: 6,11
Protein ID Length (AA) pI
7w7ps 297 5,20312
1hUjB 271 5,02163
1jVtb 305 4,77382
4CMxb 267 5,06625
4COCV 292 5,12645
4HErz 279 4,93422
4UWzW 286 4,80866
4UWza 305 5,06898
7we38 278 5,23131
boib 241 8,89794
A0A222ZJ03 317 4,81537
A0A0U4JY89 317 4,90216
A0A386KP63 317 4,90216
A0A5J6TS61 367 9,31002
A0A6B9JKT3 364 9,46359
A0A9X9P6K6 367 9,31002
A0AAE8YNR4 367 9,31002
A0AAF0GN38 361 5,10541
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_25595
3X4EC
 26 47,5% 200 4.803E-65
2 phalp2_31556
4fe7g
 22 42,7% 220 1.870E-54
3 phalp2_13827
7cMO8
 12 35,9% 203 2.614E-37
4 phalp2_38221
7wekT
 2 31,0% 312 9.432E-31
5 phalp2_30398
4MRRT
 4 36,3% 242 7.974E-28
6 phalp2_7058
8iEHQ
 9 32,2% 214 1.274E-21
7 phalp2_32194
6VJSL
 13 33,4% 215 4.260E-21
8 phalp2_18388
5HE4u
 2 23,7% 215 2.053E-07
9 phalp2_33971
40cAJ
 14 22,8% 241 1.487E-05

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7w7ps (297 AA)
Member sequence: A0A221J6E1 (317 AA)
1 297 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Arthrobacter phage Nightmare
[NCBI] 		2015864 Gordonvirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF140423 [NCBI]
CDS location
range 1557 -> 2510
strand +
CDS
ATGGTACTTCCCATTACCGGAATCAACGAACAATTCAATGCAGCTTTCTTTACCGCCGGCCCGACTGAAAAGGACGGCATCGTCATTCACTGGTGGGGTCTTCCTCAGGGCCAGGGCATCGACAGTGTGCGAACAACCTTTGGCAACGGAGGTCGTCAGGCCAGTGCGCACTTCGGTGCAACTGATGGCGAGGTCGACTGCTACGTCAATCCCGACGACGTCGCATGGGCCAACGGCAACTGGGCAGCAAACCTGTCCAAGATCTCGATCGAATGCAATCCACGACAGAGCGATGGCGATTACTACGCCGCGGCCTGGACGATCGCTTACATTCGTTCGATCTACGGCGACCTGCCGCTGTCCCGTCACTGGGATTACTACCCGACTCAGTGCTGCGGAACCTACGATCTGGAACGTCTTGATCAACTCGCGTACGACATCGCAGCAACGGGCATTTGGAACAGCTACCAGCTGCCAACTCCCGCCGCTCCTGTTGTTCCGGCTCCTCCGGCTCCGGCAACCCAGGCGAAGTCCATCGATCAGCTTGCTCAGGAAGTCATCGCAGGTGCTTACGGCACGGGCGACGCTCGACGTGTTGCTCTCGGTGGTCAGTACGACGCTGTCCAGGCACGAGTCAATGAGATCCTGACCGGCGTCTCCAATGCGAAGCCTCAGCCCAGCATCTCCGAGCTTGCTGACCGCGTTATGCGTGGAGAGTTCGGCAACGGAGATCAGCGGATCACGGCTCTCGGCAACCAGTACCAGGAAGTTCAAAATGAGATCAACCGGCGTGCCGGCATCTCGGCTCCTGTCTCGGTACCTTCGGCTCCGAACATCGAGGATCTCGTTCGACGCACTCTTGCTGGCGAGTTCGGCAACGGTGACGATCGTGTTCGTGCTCTCGGGGCAAACTACACAGCTGTTCAGGCTGAGATCAACCGCCGTTACGCATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000b5f0b45_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7w7ps) rather than this protein.
PDB ID
7w7ps
Method AlphaFoldv2
Resolution 72.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50