Protein

Protein accession
C3U2S5 [UniProt]
Representative
7xeAb
Source
UniProt (cluster: phalp2_32258)
Protein name
Putative endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVNFYSGVAGRRPGKPTFAIIHNDAGSINATASYYSHWLPTHQAELGFAHVYIAKDGRYQAENYDNMAWHAGNGYANQWALSWEVCQSLGATDADFKATEERVFQDVANAFKRYGLVPNRTTVRLHREYSATDCPHRSWALHGQAVQAVQDYFIAGIQRYMGGGSTSTGNDYTSQNTTYTLNKELLDMYLIFTVDTKRWYISNGVGVRYVRTTRMLANYQDNFGKLQLPTDKMDQSS
Physico‐chemical
properties
protein length:237 AA
molecular weight:26818,5 Da
isoelectric point:7,79
hydropathy:-0,54
Representative Protein Details
Accession
7xeAb
Protein name
7xeAb
Sequence length
261 AA
Molecular weight
29228,22640 Da
Isoelectric point
6,06582
Sequence
MTLFYSGIAGKRPGKPTFVIIHNDAGSINACASYYRSWLPNHEAELGFAHVYIAKDGKYQADDFDNIAWHSGNSFANEWALSWEVCQSMGASDAEFEAVEEAVFQDVAAAMKRYGLTPNRETVRLHKEYSATDCPHRSWALHGSAINAVQDYFIAGIKKYMGADNSSNNEKPVQPIQPTKENSTMIYAFNVQGQGATYLFDGQKTIVFAEKTSGSGQGPRAWDHYKGTYKEVTGKDLPTQTKTKEQFELWNTLYPAQFIKF
Other Proteins in cluster: phalp2_32258
Total (incl. this protein): 253 Avg length: 247,1 Avg pI: 6,83
Protein ID Length (AA) pI
7xeAb 261 6,06582
1I1Sa 234 5,97278
1dFXr 277 7,64902
1hkye 248 8,68062
1kkba 277 7,04158
1mMf1 333 9,37714
1mq5k 277 7,04101
1mrNQ 298 6,79694
1mrYY 333 9,27779
1msFI 277 7,64902
1nakP 231 7,71370
1o2BB 256 6,44306
1o4SP 248 6,13255
22dcr 275 5,22432
2VGFd 234 5,74940
2Vw5N 253 6,16086
2dhbc 232 8,28046
2jWU0 237 6,16592
2jWuB 260 6,29659
2jXHQ 240 8,77687
2jXMn 248 6,05053
2jXhz 243 6,69026
2jYLs 186 5,75332
2mb1S 258 6,35275
3GknY 234 5,46305
3LQjC 232 8,58572
3VsNE 233 6,37940
3eI8a 232 7,71370
3iFTJ 258 5,82596
3iGjx 234 6,44170
3iH2W 234 5,89514
3iI4M 270 5,31032
3jJNM 245 6,49837
3jMgN 277 7,04232
3khYA 232 8,28814
3lbMf 233 6,65348
3u5ix 259 6,18968
3vCJP 258 6,23435
3ymRl 226 8,29394
3ynpX 234 5,59304
4F1fU 256 6,70276
4fx7U 261 6,04604
5KIvY 235 6,65519
5LWy9 258 6,35405
5La1P 236 8,26364
5MkMB 258 5,97528
5NU14 258 6,05269
5P8CF 251 6,23503
5PBPG 235 6,04979
5Rz8V 234 6,49564
5Ujxe 234 5,97141
5VSMU 248 6,49837
5VSwo 212 6,48888
5VeAW 283 8,63336
5WGcs 260 6,18808
5YCVi 212 8,52841
5YWnV 233 6,65348
5ZjzO 235 5,60264
61XO4 235 5,97175
62WSa 233 6,65337
62pE9 258 5,89707
63dUj 235 5,97318
64jRF 233 7,04192
658el 234 6,29750
65dvg 235 5,88206
65vR3 240 8,77687
65xPz 232 8,57663
65y32 258 5,90446
66NmW 232 7,68949
67yDn 232 8,80891
68HEE 235 6,05235
68IIY 238 8,56774
68mJ6 232 8,58508
68rDA 236 8,77700
69PAA 235 5,97767
69tf2 234 6,12619
69waS 258 6,18473
69xfl 258 6,19132
6bPft 235 6,05315
6bu9v 258 5,74480
6cbyd 233 7,04249
6d6FQ 287 8,46259
6d6G7 233 7,04118
6gBt6 258 5,82488
6hKvF 233 6,65348
6i2Np 234 6,04815
6i7U5 251 6,18803
6iMVx 280 6,65837
6jig1 248 6,19303
6kAJh 233 6,65348
6kUFw 248 6,49939
6lwLB 287 8,67166
6m8An 235 5,88206
6n6N9 258 6,23066
6pEhp 235 6,12749
6q3xC 235 5,97579
6q4lD 233 6,65229
6trdC 259 6,18968
6tu6t 226 8,29394
6v0d1 233 6,37940
6v1jl 259 5,96891
6vP0q 231 6,11868
6vru0 254 6,29659
6vryU 234 5,97403
6wBEh 236 8,28807
73f2r 277 7,64902
76WzJ 277 7,04107
76kDS 284 7,64515
76kQ7 277 8,38329
7AoRp 233 6,12948
7Auws 258 6,12454
7BNTr 287 8,94262
7BNWL 287 8,84218
7BO2U 274 7,04101
7BXkn 277 7,07790
7BgXe 233 7,04192
7BgYm 256 7,73615
7PP0q 233 7,04175
7PPD6 258 5,96897
7PPEX 233 7,04192
7PPIN 253 5,87320
7QAzy 277 7,07790
7QDLO 277 7,04101
7VbQb 240 8,78706
7W2VT 234 5,83204
7WQFb 233 7,04175
7XP1w 234 5,68637
7XTB0 248 6,49939
7XVYd 234 5,46305
7YgF3 260 6,18808
7YygD 236 8,56774
7ZFoo 240 8,77687
7aTlF 261 5,97175
7aTns 233 6,38043
7cW0m 277 8,38323
7elpt 277 7,04198
7ezHY 256 6,44312
7giEq 327 6,36184
7jC4p 234 5,46305
7jxrs 234 5,97698
7kai8 277 8,58256
7mHt3 277 7,07801
7xTOf 274 5,53944
7xTTm 259 5,20954
7xTiD 280 9,11900
7zLkj 258 6,05440
7zTXA 234 5,82903
7zU1I 234 6,12948
7zU4h 258 6,29659
7zU59 235 6,12749
7zU6V 235 5,74127
7zUdc 242 8,77687
7zUe5 240 8,57650
7zUhA 252 6,18808
7zUis 252 6,19689
7zVEt 244 8,77687
7zVGn 249 6,29005
7zVIZ 238 8,77687
7zVzh 233 6,65280
7zodk 233 7,04175
81O1U 277 7,04198
81g5D 235 6,12550
81grd 234 6,05730
85utO 236 8,56774
879YV 248 6,10840
87GZR 258 6,35275
87aAb 249 6,19564
87aCu 258 6,12249
87aJ1 233 7,04118
87axA 248 6,30165
88BGs 235 7,04294
88EvG 233 6,65337
890MR 258 6,29505
8GYnO 248 7,11723
8GYny 258 6,29500
8GYo5 235 5,97141
8GYoC 234 5,97141
8GYoK 234 6,12619
8GYoP 234 6,23378
8GYoS 238 8,77687
8GYoT 234 5,79959
8GYoj 226 7,71768
8GYok 234 6,12619
8GYop 235 5,59201
8GYp6 238 8,77687
8GYp7 238 8,77687
8GYpf 235 6,12420
8GYpk 234 5,74213
8GYpl 233 6,37935
8GYpm 256 8,75747
8KW5g 237 7,78754
8LNav 233 7,04118
8LSIy 234 5,74213
8Lrhy 249 6,15438
8Lv8F 249 7,08438
8M43z 258 6,29505
8MLBB 232 8,27847
8MLS7 260 5,78822
8MLTT 252 5,84790
8MLWp 258 6,05440
8MLXq 258 6,18808
8MLZg 232 8,79763
8Mgjx 232 6,70225
8Mgkn 240 8,77687
8MoMi 236 8,57650
8MuS5 258 6,29699
8MuXh 233 7,04192
8MvdO 237 6,37940
8MveM 232 8,59571
8Mvhg 228 8,60455
8Mvi9 248 6,49678
8Mvja 234 6,13079
8Mvk1 233 6,37940
8MvkY 248 6,44386
8MvmG 258 6,15927
8Mvoo 260 5,97090
8MvpX 260 6,29500
8Mvpd 235 5,89445
8MvqP 258 6,29653
8My2p 238 8,77687
8d1Jp 193 6,22480
8d1Po 242 5,65448
8d1VU 248 6,13124
8d1u4 274 7,11530
8eB6g 233 7,04175
8eOFf 233 7,04175
8ezEA 235 6,12749
8fL6M 248 6,54782
8ffSb 238 8,57650
8fgbh 248 6,13647
8hci7 277 7,04050
8kRjU 234 5,56320
8kRp7 235 6,12749
8loxl 234 6,05065
8lqNh 235 6,12749
8lv8P 233 6,65337
8oS2K 233 6,65229
8oaTG 248 6,75176
8oqPj 234 5,73906
8r0AB 277 7,04101
8r0hZ 233 7,04175
8rzZK 226 8,27847
8s78p 238 8,57650
8sYhI 233 7,04175
8tJid 234 8,94932
8v5c6 277 7,04175
CBRb 270 5,39734
Yu2H 234 6,23390
A0A1W6JIU0 249 6,29005
A0A455VPF3 249 6,15438
A0A5Q2F377 249 7,08438
A0AA96SFN9 249 7,09040
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15488
8diNj
 63 52,6% 167 7.750E-68
2 phalp2_7790
7qCWn
 51 44,0% 200 1.442E-61
3 phalp2_31265
8lSNT
 54 31,2% 266 1.108E-50
4 phalp2_36839
6Z1Os
 11 41,7% 163 1.353E-49
5 phalp2_15359
1El58
 3 33,6% 208 4.733E-41
6 phalp2_23554
7slSx
 8 20,0% 239 3.358E-19
7 phalp2_24730
6BIOG
 3 25,2% 178 1.298E-14
8 phalp2_16558
7rWDg
 20 28,9% 173 7.817E-14
9 phalp2_13879
7z7dc
 255 25,1% 175 5.388E-11
10 phalp2_28347
1dvAn
 6 22,9% 231 4.675E-07

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 7xeAb (261 AA)
Member sequence: C3U2S5 (237 AA)
1 261 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactococcus phage P087
[NCBI] 		641487 Teubervirus > Teubervirus P087
Host Lactococcus lactis
[NCBI] 		1358 Firmicutes > Bacilli > Lactobacillales > Streptococcaceae > Lactococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
FJ429185 [NCBI]
CDS location
range 53855 -> 54568
strand +
CDS
GTGGTTAACTTTTATTCTGGGGTTGCTGGTCGAAGACCTGGCAAGCCAACGTTTGCAATCATCCATAATGACGCTGGTAGTATTAATGCAACAGCAAGTTACTACAGTCATTGGTTGCCAACTCACCAAGCAGAACTAGGTTTTGCTCATGTTTATATTGCTAAAGATGGTCGTTATCAAGCTGAAAACTATGATAACATGGCTTGGCATGCTGGTAATGGTTATGCTAATCAATGGGCTTTATCTTGGGAGGTTTGCCAATCTCTTGGAGCTACTGACGCTGACTTCAAAGCAACAGAAGAACGTGTCTTCCAAGATGTAGCAAATGCTTTTAAACGGTATGGTCTTGTACCAAACCGAACTACTGTTCGCTTACACCGTGAGTACTCAGCCACAGACTGTCCTCACCGTTCATGGGCTTTACATGGTCAAGCTGTTCAAGCAGTTCAAGACTACTTTATCGCAGGTATTCAACGTTACATGGGTGGAGGTTCTACTTCTACTGGTAACGATTATACTTCACAAAACACAACATACACACTTAATAAGGAGTTACTAGATATGTATTTAATTTTCACTGTAGACACCAAACGTTGGTACATTTCAAATGGTGTAGGAGTTCGATATGTTCGGACAACAAGAATGTTAGCAAATTATCAAGATAATTTTGGTAAATTGCAACTACCTACTGATAAGATGGATCAATCAAGTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi00019dc1b8_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7xeAb) rather than this protein.
PDB ID
7xeAb
Method AlphaFoldv2
Resolution 86.26
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50