Protein

Protein accession
Q6IWQ8 [UniProt]
Representative
1poOc
Source
UniProt (cluster: phalp2_1409)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTTLSKRVLALVAAGASALTIATQFLHEKEGDRLIAYQDTGGKWTACMGVTRGVKPHARYTQAECDRMDAQAVAGAETDVESLVTVPMSKPQRAAVISFCGYNLGATKCSKSTFLRLLNEGKRKEACEEIKKWTYVGGKDCTDASNNCRGIPLRRDQEYQLCLMD
Physico‐chemical
properties
protein length:165 AA
molecular weight:18073,6 Da
isoelectric point:8,62
hydropathy:-0,33
Representative Protein Details
Accession
1poOc
Protein name
1poOc
Sequence length
78 AA
Molecular weight
8590,63570 Da
Isoelectric point
8,66179
Sequence
MSPAARAGTASFCVHNIGPGKCRQSTFLRLLNEGRRNEACAEITKWIRDGGKDCRDPAAGCRGQVDRRQQEDELCLTP
Other Proteins in cluster: phalp2_1409
Total (incl. this protein): 22 Avg length: 93,1 Avg pI: 9,04
Protein ID Length (AA) pI
1poOc 78 8,66179
1Z1qJ 94 8,61602
2lkDY 78 8,70499
3OCQ8 86 8,62621
6Si5R 97 9,02075
6Sj1J 97 9,19314
723XI 78 8,92521
72ImX 89 9,21390
732Of 89 9,58111
73Fqz 89 9,41350
73TF0 89 9,53908
73uv7 111 9,22802
75MO8 74 8,61596
7RXJE 56 8,85514
7SeJ6 90 9,05370
7lN5x 114 9,36805
7nGYB 86 8,82651
7rD8P 108 9,34232
7sK91 101 8,82696
8Hj0B 90 9,23924
epI 89 9,38068
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_34945
4CAeh
 9 55,3% 47 6.252E-23
2 phalp2_14837
7sNfr
 34 39,3% 61 4.929E-12
3 phalp2_22140
6BYUy
 22 38,9% 77 2.242E-10
4 phalp2_37101
1bvx6
 877 33,7% 74 9.483E-08
5 phalp2_26702
2OTih
 81 40,0% 60 2.465E-07
6 phalp2_7764
77796
 37 34,2% 76 4.661E-07
7 phalp2_17438
7Fv8C
 39 35,4% 62 6.408E-07
8 phalp2_19632
4jTZ6
 10 32,7% 55 3.150E-06
9 phalp2_1365
1dLHt
 2 29,1% 48 4.332E-06
10 phalp2_24173
2nDwl
 15 33,8% 71 3.747E-04

Domains

Domains [InterPro]
GH24
Representative sequence (used for alignment): 1poOc (78 AA)
Member sequence: Q6IWQ8 (165 AA)
1 78 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Burkholderia phage BcepB1A
[NCBI] 		279530 No lineage information
Host Burkholderia cenocepacia
[NCBI] 		95486 Proteobacteria > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Burkholderia > Burkholderia cepacia complex

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AY616033 [NCBI]
CDS location
range 727 -> 1224
strand -
CDS
ATGACCACACTGAGCAAACGAGTGCTTGCGCTCGTGGCGGCGGGGGCTTCGGCCCTCACTATCGCGACGCAGTTCCTGCACGAAAAAGAAGGCGACCGCCTGATCGCATATCAGGATACGGGCGGTAAGTGGACGGCCTGCATGGGCGTGACGCGCGGGGTTAAGCCTCACGCGCGATATACGCAGGCCGAATGCGATCGGATGGATGCACAAGCCGTCGCGGGTGCAGAAACGGATGTCGAATCGCTTGTCACGGTTCCGATGTCGAAGCCGCAACGTGCAGCCGTAATTTCGTTTTGCGGCTATAACCTTGGCGCAACCAAGTGCAGCAAATCAACGTTTCTGCGGCTGCTGAATGAAGGCAAACGCAAAGAAGCGTGTGAAGAAATCAAGAAATGGACATACGTTGGCGGGAAAGACTGCACCGACGCATCTAACAATTGTCGGGGTATCCCGCTCCGACGCGATCAGGAATATCAACTATGCCTGATGGACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi00003779ba_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1poOc) rather than this protein.
PDB ID
1poOc
Method AlphaFoldv2
Resolution 97.76
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50