Protein

Protein accession
A0A088F8C4 [UniProt]
Representative
eXTW
Source
UniProt (cluster: phalp2_6414)
Protein name
NlpC/P60 hydrolase family protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 75% (predicted by ML model)
Protein sequence
MTSAEYVNAVVGTPWVLAGNDWGAFDCWGLVEHSYRALDGVSLPPVEPRDDVQGAFSNVGWVQECDECEGAIFGVVDAEGNMHHVGRVLAGMHVHAHGSRNKTGQTRASTKRELLRFFRDNEIKYYKVTL
Physico‐chemical
properties
protein length:130 AA
molecular weight:14407,0 Da
isoelectric point:5,60
hydropathy:-0,29
Representative Protein Details
Accession
eXTW
Protein name
eXTW
Sequence length
138 AA
Molecular weight
15251,18840 Da
Isoelectric point
7,72222
Sequence
MTPKEFLNHAIGKPWVGRATGPQAYDCWGLVIASFREIEGLELPIVNGYAYSSGSPNEIESELRNKGRFIKSTGIDGDIVSMYNRVGDFEHVGRIICGGIVHAWGQGGNGTGQVKWNTIAAMKKLYPRLEFERYAVNC
Other Proteins in cluster: phalp2_6414
Total (incl. this protein): 41 Avg length: 136,0 Avg pI: 6,31
Protein ID Length (AA) pI
eXTW 138 7,72222
14c6i 131 5,74474
16aYr 141 8,92811
1KweS 144 5,77549
28EYJ 141 5,49192
296Fa 140 6,35832
299Oc 135 6,40333
2IzeL 139 6,18462
2gNCI 131 7,59388
2gPen 129 6,10186
2k0AF 136 7,57729
4CzYs 139 6,18825
4InO9 135 6,39918
4PpNG 129 5,90753
4UoY3 131 5,30458
4lxkK 134 6,50303
4mpCG 138 6,28374
4tiN7 140 5,66102
4uviZ 130 6,87896
4zOMR 144 5,56672
7KlBu 132 6,06105
7QqMb 135 6,94921
81KOO 139 5,64038
8A1Ik 134 5,14702
8AHg8 139 5,74701
8hmo 132 4,84464
8n3kb 134 5,77498
RCTA 133 6,28909
VLzj 141 5,93225
WEKq 136 5,38472
M4Q149 135 6,94921
A0A2I7QK42 138 7,00003
A0A2I7QVY1 134 6,27607
A0A2I7R6Q4 138 7,00003
A0A2I7R6W5 138 7,00003
A0A2I7RPW4 134 5,58195
A0A2I7RQE7 138 7,00003
A0A2I7RWZ9 138 6,94887
A0A2I7RX68 138 6,94887
A0A3Q9R5V9 135 6,26038
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_2992
1c0mX
 989 36,4% 137 1.441E-33
2 phalp2_35007
4PoFU
 13 27,3% 128 5.573E-24
3 phalp2_25284
8eHr9
 73 32,8% 137 3.690E-23
4 phalp2_15126
8Bavd
 2 29,3% 92 2.031E-17
5 phalp2_26190
8FPti
 9 26,8% 138 9.773E-17
6 phalp2_19713
4Ktlf
 40 32,0% 134 6.435E-16
7 phalp2_25010
PR2K
 31 25,5% 133 3.804E-14
8 phalp2_30783
cA3P
 33 28,1% 135 1.333E-13
9 phalp2_14093
8iNl2
 704 30,7% 140 2.495E-13
10 phalp2_12078
5kO9x
 1 28,5% 140 4.178E-12

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage Idiomarinaceae phage Phi1M2-2
[NCBI] 		1527515 No lineage information
Host Idiomarinaceae bacterium M2-2
[NCBI] 		1510937 Proteobacteria > Gammaproteobacteria > Alteromonadales > Idiomarinaceae >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KM226324 [NCBI]
CDS location
range 17182 -> 17574
strand +
CDS
ATGACATCGGCAGAGTATGTTAATGCAGTGGTCGGTACGCCGTGGGTGTTAGCGGGTAATGATTGGGGTGCGTTTGATTGCTGGGGTCTGGTCGAGCATTCTTACCGCGCGCTTGACGGTGTGAGCTTGCCGCCCGTAGAGCCGCGAGACGACGTGCAGGGCGCTTTTAGCAATGTGGGCTGGGTGCAAGAATGCGACGAGTGCGAAGGCGCTATCTTTGGCGTTGTGGACGCTGAGGGGAACATGCACCACGTCGGTCGTGTGTTAGCCGGTATGCACGTTCACGCGCACGGAAGCCGCAACAAGACAGGGCAAACGCGAGCCAGCACCAAGCGCGAATTGCTGCGCTTTTTCCGCGACAACGAAATCAAATACTACAAGGTCACGTTATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (eXTW) rather than this protein.
PDB ID
eXTW
Method AlphaFoldv2
Resolution 86.56
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50