Protein

Protein accession
A0A0R8VCQ3 [UniProt]
Representative
7lwdD
Source
UniProt (cluster: phalp2_24821)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MMPRPDRYVSRSDLGWGRSPAASANPKLGLVIHYDGSNQNLAAKTHAACISYWKNTRAFHTGPARGWVDIGYSWGVCPHSYVFEGRGLYKTQAAQPGGNTTYYSVTLMCGPTDTITDVQINAVRQLRAWLMETAGVAGTVKGHRDFVSTSCPGDALYRMVRDGVFSKPATWGGTSSSWEELMLGLKKGDRGEAVEALQELIRLAGHGAALGPAGVDGVYGDGTAEGLRLCRADVGSRALPGYGDKVTGHAFAQLIAAVAKHQATKVSGGSTGGVPRHLEVESLTAKRLTVG
Physico‐chemical
properties
protein length:291 AA
molecular weight:30849,5 Da
isoelectric point:9,17
hydropathy:-0,24
Representative Protein Details
Accession
7lwdD
Protein name
7lwdD
Sequence length
356 AA
Molecular weight
37842,13650 Da
Isoelectric point
9,97250
Sequence
MRLERRSSFGWGPSGGGYANPRNGLVVHYDGSNQGLAGRSHSACRAYWINTRKFHVNTRDWSDIGYSWGVCPHNYVLEGRGLNRAQAAQPGGNTTWYSVTFMCGPNERPTDGQITAFRQLRAYLMGRGVAGAVSYHGRFIPTSCPGAILRGMVTSGDLINGSAGGSTPARPRPLGRQHASGTLVGGPANAAVVPYGSPVLKRGAVAANVAAAQDAIVRAYGAESADCRIEVDGHFGTATERAVTYANRKLKTKHGGVWNRGTHQGLRAVLGGPMVAWHVDEDVPVPSLVKGDTGERVRNLQRLLMRAGYDLPRYGADGDFGEETRAAVLALNRASGTTHGGVYGLGTAYALLLALR
Other Proteins in cluster: phalp2_24821
Total (incl. this protein): 3 Avg length: 305,7 Avg pI: 9,48
Protein ID Length (AA) pI
7lwdD 356 9,97250
A0A3T0IDD9 270 9,28636
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36432
11r0n
 207 35,0% 248 4.568E-36
2 phalp2_26920
4uKrS
 7 29,3% 364 2.024E-33
3 phalp2_784
240oa
 2 27,0% 347 5.497E-27
4 phalp2_37752
4kTIO
 51 31,0% 229 1.053E-22
5 phalp2_13951
8FOsh
 28 29,6% 256 1.617E-20
6 phalp2_30759
3icm
 1 27,0% 310 1.482E-14
7 phalp2_36077
6wXXD
 2 25,9% 420 4.706E-13
8 phalp2_36521
1qwup
 277 24,4% 294 5.797E-09
9 phalp2_19675
4Bope
 30 26,8% 235 1.579E-05

Domains

Domains [InterPro]
Unannotated
Unannotated
PG_1
Representative sequence (used for alignment): 7lwdD (356 AA)
Member sequence: A0A0R8VCQ3 (291 AA)
1 356 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01471

Taxonomy

  Name Taxonomy ID Lineage
Phage Thermobifida phage P1312
[NCBI] 		1661715 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KT021004 [NCBI]
CDS location
range 25970 -> 26845
strand +
CDS
ATGATGCCACGCCCTGACCGGTATGTGTCACGTTCTGATCTCGGTTGGGGGCGCTCCCCGGCCGCGTCCGCCAACCCGAAGCTGGGGCTAGTCATCCACTACGACGGGTCCAACCAAAACCTTGCCGCCAAAACCCACGCCGCCTGTATCAGCTACTGGAAGAACACCCGCGCGTTCCACACCGGACCGGCGCGGGGCTGGGTGGACATCGGCTACTCCTGGGGAGTTTGTCCGCATTCGTATGTTTTCGAGGGGCGCGGGCTGTACAAAACCCAGGCCGCCCAGCCCGGGGGGAACACGACCTACTACTCGGTGACGCTCATGTGTGGACCCACCGACACGATCACCGATGTCCAGATCAACGCGGTCCGGCAGCTGCGCGCATGGCTCATGGAAACCGCCGGGGTCGCCGGGACGGTCAAGGGCCACCGCGACTTCGTCTCCACGTCCTGTCCCGGGGATGCGCTTTACCGGATGGTTCGCGACGGGGTGTTCAGCAAGCCCGCTACGTGGGGTGGGACGTCGAGCAGTTGGGAGGAACTGATGCTTGGGCTGAAAAAGGGTGATCGAGGCGAGGCCGTCGAGGCGTTGCAGGAGCTCATCCGGTTGGCGGGGCACGGGGCGGCGCTCGGCCCCGCCGGCGTGGACGGCGTGTATGGGGATGGCACTGCTGAGGGGCTGCGGCTGTGCCGGGCTGATGTGGGCAGCCGCGCCCTCCCCGGCTACGGAGACAAGGTCACCGGGCACGCGTTTGCCCAGCTCATCGCCGCCGTCGCCAAACACCAGGCGACAAAGGTTTCCGGGGGCAGCACTGGTGGGGTGCCTCGGCACCTGGAGGTCGAGTCGCTGACCGCGAAGAGGCTCACCGTGGGTTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A0R8VCQ3
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7lwdD) rather than this protein.
PDB ID
7lwdD
Method AlphaFoldv2
Resolution 79.85
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50