Protein

Protein accession
A0A2H4PI36 [UniProt]
Representative
6ThID
Source
UniProt (cluster: phalp2_17671)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKWVSRAELGWPASAAPSQTSTKGVKVHYEGTRVDCDTHAECVSLVKAIRKSHLANKVENYSDIAYNLIVCKHGYVFEGRGKRKRTGANGNQALNQAHYAVMGLLGSSGDTEPTDEMIEGIKDAIAYLRSNGAGKEIKGHKDGYATKCPGDALYALVRAGKLEPGANAPAPKPKPVYAPFPGRGFFRLGQRHDLITELGKALVRAGWKGYKIGPGREFTRTDIKAVAWFQRKQGWTGSDADGYPGPETWKRLKVAQPKK
Physico‐chemical
properties
protein length:259 AA
molecular weight:28267,9 Da
isoelectric point:9,71
hydropathy:-0,60
Representative Protein Details
Accession
6ThID
Protein name
6ThID
Sequence length
314 AA
Molecular weight
33204,00760 Da
Isoelectric point
6,61244
Sequence
MPRKGPTLKLVTRAQLGWPASAAPTQTTAKGVKVHYEGTAVSTRLLTDHNACIAEWKAIRASHLANTAENYSDVAYNYAACPHGYLLEGRGLRKRTGANGNQTLNIAHYAIVGLVGSSGLTKPTDAMLGAIRDGIELLRKNGAGTEIKGHRDGYATACPGPELYAWVQKGAPRPTTTTPPQEDDAMPTAAEIAEAVVAKLLAGGGVLENSDLDRLFSRDAIPAARPPYNNPDYFGADGKTVANDSWTFKYAVQTAVENAREAVARIKNLEGTVGAVELTDAQVASLATAVVSNPAFAEEIAERVAVKLAERLAD
Other Proteins in cluster: phalp2_17671
Total (incl. this protein): 74 Avg length: 272,1 Avg pI: 8,80
Protein ID Length (AA) pI
6ThID 314 6,61244
15OpE 250 6,10157
1IdEp 256 9,67853
1gMKR 239 9,14079
3X7t9 276 9,06002
3ebMa 261 9,57473
3ezWp 262 8,83618
3fHiG 256 9,53031
4HAmk 239 9,23253
4NU0D 317 5,72127
5e6vM 266 9,73133
5inaa 253 9,38461
6D5KE 263 8,31760
6DQb4 281 9,55217
6DnAR 276 9,41524
6Dov5 279 8,99484
6EYZp 279 8,84914
6EkFP 283 8,97041
6FoyP 274 9,13899
6FrLN 266 9,19592
6GtYe 280 7,18748
6ISI2 283 8,99510
6IYT6 277 8,99471
6J8UY 263 9,17161
6RN1H 255 6,75096
6S1Zd 255 6,54503
6TSu9 270 5,14441
6TbAV 264 9,51394
6TeSd 315 9,70270
6TfxR 246 9,23460
6Tg7Z 302 6,11669
6TgH1 278 7,16731
76rr6 324 9,29997
7Iav6 302 6,25993
7baWD 276 7,77561
7caDO 273 9,21248
7gCM8 280 8,69416
7o4LO 285 9,66396
7o6C4 281 7,72939
7o6d2 264 9,68110
7o7wq 282 9,15279
7ouz8 292 8,99684
7p243 286 6,75181
7pYm9 260 9,34245
7qWzR 282 9,31550
7r7Cq 257 9,21268
7uOSR 273 9,20604
7ucKS 320 6,10260
7ukur 269 9,61502
7ulCX 315 8,89291
7ulz5 265 9,29842
7ulzY 248 9,16736
7yXGJ 270 9,57428
7zeJI 267 9,27154
7zgkB 329 9,71714
7zgmp 268 9,37746
7zhzb 261 9,25452
7ziIH 263 9,54733
7zit1 276 9,58118
7zk21 329 9,82113
7zkiS 263 9,60716
7zmr6 250 9,21667
8Jtqk 233 9,64287
8Jtql 259 9,71153
QPEW 258 9,68188
iFCv 255 6,75096
inG 259 9,74254
A0A2H4PQW8 233 9,64287
A0A2U8UMZ7 257 9,61805
A0A5P8D7R4 255 9,61805
A0A7G9UY40 259 9,75924
A0A6C0RTR1 259 9,74254
A0A9E8M6Q0 258 9,51613
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36432
11r0n
 207 45,5% 283 1.633E-72
2 phalp2_37752
4kTIO
 51 35,5% 200 4.379E-33
3 phalp2_15382
1LWAy
 5 31,6% 202 4.337E-31
4 phalp2_23799
1eilo
 4 36,4% 195 7.800E-29
5 phalp2_14770
6TKha
 3 29,1% 233 2.109E-25
6 phalp2_11750
42dFf
 4 28,6% 237 2.420E-21
7 phalp2_23216
7DAyW
 82 31,8% 204 1.597E-19
8 phalp2_21638
2SCDc
 2 32,5% 203 2.152E-19
9 phalp2_20947
7lyTA
 33 28,6% 223 2.670E-16
10 phalp2_26274
RjMA
 376 24,1% 199 3.586E-16

Domains

Domains [InterPro]
Unannotated
Unannotated
Disordered region
Representative sequence (used for alignment): 6ThID (314 AA)
Member sequence: A0A2H4PI36 (259 AA)
1 314 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptomyces phage WRightOn
[NCBI] 		2053723 Manuelvirus > Manuelvirus wrighton
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG515223 [NCBI]
CDS location
range 2976 -> 3755
strand +
CDS
ATGAAGTGGGTATCGCGTGCAGAGCTGGGGTGGCCAGCAAGTGCAGCACCGAGCCAGACGAGCACGAAGGGCGTGAAGGTCCACTACGAGGGAACCCGAGTCGACTGTGACACGCACGCAGAGTGCGTGTCTCTGGTCAAGGCGATCCGCAAGAGCCACCTCGCCAACAAGGTGGAGAACTACTCGGACATCGCCTACAACCTGATCGTCTGCAAGCATGGCTACGTCTTCGAGGGGCGAGGCAAGCGCAAGCGCACTGGGGCGAACGGGAACCAGGCGCTCAACCAGGCGCACTACGCGGTCATGGGACTCCTTGGCTCCAGTGGAGATACCGAGCCTACTGACGAGATGATCGAGGGCATCAAGGACGCCATCGCCTACCTGCGCTCCAATGGGGCTGGCAAGGAGATCAAGGGACACAAGGACGGTTATGCCACCAAGTGCCCTGGAGACGCCCTGTACGCCCTTGTGCGGGCCGGAAAGCTGGAGCCTGGAGCGAATGCTCCAGCGCCCAAGCCGAAGCCCGTCTACGCCCCCTTCCCGGGCCGTGGCTTCTTCCGTCTAGGGCAGAGGCACGACCTCATCACTGAGCTGGGCAAGGCGCTCGTGAGGGCCGGATGGAAGGGCTACAAGATCGGGCCGGGCCGAGAGTTCACCAGGACCGACATCAAGGCTGTCGCATGGTTCCAGCGCAAGCAGGGCTGGACCGGAAGCGACGCCGATGGATACCCAGGTCCGGAGACGTGGAAGCGACTGAAGGTCGCTCAGCCAAAGAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000ca2257c_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (6ThID) rather than this protein.
PDB ID
6ThID
Method AlphaFoldv2
Resolution 75.49
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50