Protein

Protein accession
A0A2D1GAU5 [UniProt]
Representative
1fUkE
Source
UniProt (cluster: phalp2_32493)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTTRLNVEFAKKILVDRIGNNYVYGGNWDPFNLKKGTDCSGLVIDICDAVRNGTKMAWSRHGMSTETWRPPSMGGRANPVNGPFGTVMVNHPSQFPDNAIVKIAIHHGPGGGANSHTWCSVDGMRGESAGSKGCVTGSAARDPYDTSYANNWWYLPGPIVEDGSPIPEDPNAVTWGIDISNHQGEMDLNRVKAEGFDFIWCKVSEGANYRDPFWPGNRDKARAAGLILAGYHYVRTGDPAAQAKTFVEHLGDKSIPAMLDFEDGSGNIEQFWAVKAEIEKLGVQVRLSYIPDWYWERIGKPDLSKVPGLISSEYVSGTGYASVLYPGNSSNFWKAYGGRTPDVLQFTDRALVAGKSVDANAFRGTPDKLRRLLGAGGDDFLSALSDAEQRLLFDRTNQLWGALFNPIASLSKYRAEGEGEVHKTKDLVRNIDAMTHETLVERQAMMGNPEALALVKREADKGDKWAACVYKYCTEEA
Physico‐chemical
properties
protein length:477 AA
molecular weight:52399,2 Da
isoelectric point:5,87
hydropathy:-0,44
Representative Protein Details
Accession
1fUkE
Protein name
1fUkE
Sequence length
326 AA
Molecular weight
36588,04830 Da
Isoelectric point
9,63714
Sequence
MTVYGLDVSHYQSPGLDLDADNLKRQGYQFVMVKATEGSDYRDPAYHAYRTEAQKEGMLFAAYHFLKHGDIAKQVDNFVGFVTDKSIPIMLDVESNGATVADANQFRAEMEKRGRRVTLLYLPHWYWTTLGSPSLKGWTVVSSSYPSSAHKVGSALYPGDNGAGWAAYGGVSPTIWQFASSGEVSGYAGNVDLDAFKGTLDGLIGKNLFKNYGPKPKKKPDTLVAYVQRNYKNNGHKRFRLIALDKAVKNGRTGIVKDVRDEIVRLVNSLPDDPDNSYVHQVKDYFQKYRVIKMGRLNQAVNRGRKGKVRQIRDEIVKQINRLPAR
Other Proteins in cluster: phalp2_32493
Total (incl. this protein): 14 Avg length: 344,0 Avg pI: 5,66
Protein ID Length (AA) pI
1fUkE 326 9,63714
16IkE 287 5,24228
3R9P4 309 4,71169
4EAXl 321 5,20778
4uzzR 291 5,39131
5zCS2 302 5,11263
6IP2T 330 4,82514
6W48l 295 5,11701
fhLI 300 6,28784
hp2g 314 4,86118
hpkC 314 5,40354
A0A076YQC8 480 5,92020
A0A068F1N1 470 5,70882
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8437
Ypuv
 26 41,1% 231 1.070E-67
2 phalp2_18920
24XdO
 30 40,0% 207 3.329E-66
3 phalp2_16646
gfrU
 11 38,0% 213 1.413E-64
4 phalp2_1777
2SfqX
 42 37,2% 247 1.718E-63
5 phalp2_23893
1IwiZ
 3 34,9% 209 2.725E-59
6 phalp2_20034
1pbFu
 55 38,6% 207 5.084E-59
7 phalp2_9356
bl0n
 11 36,4% 233 9.483E-59
8 phalp2_33266
5EtB5
 7 37,0% 232 5.759E-50
9 phalp2_36898
7vYe1
 51 41,9% 205 3.255E-48
10 phalp2_14099
7owJl
 20 35,5% 211 3.174E-41

Domains

Domains [InterPro]
GH25
Unannotated
Disordered region
Representative sequence (used for alignment): 1fUkE (326 AA)
Member sequence: A0A2D1GAU5 (477 AA)
1 326 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage DmpstrDiver
[NCBI] 		2041530 Omegavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF919504 [NCBI]
CDS location
range 40296 -> 41729
strand +
CDS
GTGACAACTCGACTCAATGTAGAGTTCGCTAAAAAAATCCTCGTCGACCGCATCGGAAACAATTACGTTTACGGCGGAAACTGGGACCCCTTCAATCTAAAGAAGGGTACAGACTGCTCAGGTCTCGTTATTGACATCTGCGACGCCGTCCGGAACGGCACCAAGATGGCGTGGTCCCGTCACGGGATGTCCACCGAGACGTGGCGCCCCCCGTCGATGGGCGGCCGCGCCAACCCCGTCAACGGCCCATTCGGCACGGTGATGGTCAATCACCCCTCCCAATTCCCGGACAACGCCATCGTTAAGATCGCTATCCACCACGGGCCCGGAGGCGGGGCAAACTCCCACACTTGGTGCTCTGTCGATGGGATGCGGGGAGAGTCCGCGGGCAGCAAGGGCTGCGTAACGGGCTCGGCCGCGCGCGACCCCTACGACACATCGTATGCCAACAACTGGTGGTACCTCCCCGGCCCAATCGTCGAAGACGGCAGCCCCATCCCGGAGGACCCCAACGCGGTCACCTGGGGTATCGACATCTCCAATCACCAGGGCGAGATGGACCTTAACCGCGTCAAGGCGGAGGGGTTCGATTTCATCTGGTGCAAGGTGTCGGAGGGCGCGAACTACCGCGACCCGTTCTGGCCGGGTAACCGGGATAAGGCCCGCGCCGCCGGCCTGATCCTGGCGGGCTATCACTACGTCCGCACGGGGGACCCTGCCGCTCAGGCAAAAACCTTCGTGGAGCACCTGGGGGATAAGTCCATCCCCGCCATGTTGGATTTTGAGGACGGCTCGGGGAACATCGAGCAGTTCTGGGCGGTCAAGGCCGAGATTGAAAAGCTCGGCGTCCAGGTCCGCCTGTCCTACATTCCTGACTGGTACTGGGAGCGCATCGGAAAGCCGGACCTGTCCAAGGTCCCCGGTCTGATCTCGTCCGAATACGTCAGCGGAACCGGATACGCATCGGTGCTATATCCGGGTAATTCAAGCAACTTCTGGAAAGCGTACGGCGGCCGGACGCCCGACGTCCTGCAGTTCACCGACCGCGCCCTCGTGGCCGGCAAGTCGGTCGACGCCAACGCCTTCCGGGGAACACCAGACAAGCTGCGCCGTCTTTTGGGCGCGGGAGGAGATGACTTCTTGTCCGCATTGAGTGACGCAGAACAGCGGCTGCTCTTTGATCGCACCAATCAGCTGTGGGGCGCCCTTTTCAATCCGATCGCCTCGCTGTCGAAATACCGCGCCGAGGGCGAGGGCGAGGTCCACAAGACGAAGGACCTGGTCCGGAACATAGACGCCATGACGCATGAGACCTTAGTCGAGCGTCAGGCCATGATGGGCAATCCCGAGGCTCTCGCCCTCGTTAAACGCGAGGCCGACAAGGGCGACAAATGGGCCGCCTGTGTCTACAAGTACTGCACAGAGGAGGCCTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000218ec13_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1fUkE) rather than this protein.
PDB ID
1fUkE
Method AlphaFoldv2
Resolution 80.33
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50