Protein

Protein accession
A0A345MCG4 [UniProt]
Representative
8JOmU
Source
UniProt (cluster: phalp2_14937)
Protein name
Lysin A, N-acetylmuramoyl-L-alanine amidase domain
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSVAIIGAIARENVRLGGISRYTQGWETRGNGQRSNYGGILLHHTAGGRNVNIDQILINGRWDLAGPLCNFCIMYDGDIGVIAAHPANHAGASGGWDTSPFARTGLFNSQIIGVEIQYPGTEPMAQVQYEAAKRLTNATLNVLGKPRDYRWAKFHQGTSIEGKWDPGYHPSGKTYSIAQFRKDCAGMPAAAGENPDSPTWQDNRFQLLGPKAA
Physico‐chemical
properties
protein length:213 AA
molecular weight:23099,0 Da
isoelectric point:8,79
hydropathy:-0,42
Representative Protein Details
Accession
8JOmU
Protein name
8JOmU
Sequence length
218 AA
Molecular weight
23448,23500 Da
Isoelectric point
6,05440
Sequence
MAFVNGPQMMRDIATMCNQRYGINIVYAPGWETRGNGQSWPAGGPKGFIDHHTAGGNNIYLDQNLISGIPGLSGPLCNFAGLYDGDLAVVAAYPANHAGASGGWDTAPLPNTSMFNREVLGIEMQYRGTEPMSPAQYRTMCAVNRCAAIVLGWKNMNVIKTHNGTSIQGKWDPGYAPGKTYDINKIRSDATALDPNGSASEDPKIFDAIMTQLMGTRD
Other Proteins in cluster: phalp2_14937
Total (incl. this protein): 50 Avg length: 211,7 Avg pI: 6,72
Protein ID Length (AA) pI
8JOmU 218 6,05440
7A7KS 209 6,20610
7AcXn 210 6,42925
7Aedi 210 6,42061
7PK4z 213 9,00992
7PKsA 211 7,00821
7Qppw 209 6,20610
7jHgX 211 6,43135
7jwQS 216 5,90235
7kBym 208 6,28300
7zSq6 210 6,42050
8JOmV 213 8,79067
8JOmW 211 6,43124
8LhIp 217 5,92782
8Ltww 210 6,42050
A0A0E3T6F9 218 6,05440
A0A0K0N5F1 209 6,20610
A0A2K9VED9 210 6,42925
A0A5Q2WFK8 210 6,42061
A0A166Y6M9 213 9,00992
G8FS21 211 7,00821
A0A0K0N5D8 209 6,20610
A0A166Y5E2 211 6,43135
A0A0K0NKI0 216 5,90235
A0A6G9LB46 210 6,42050
A0A2H4PG13 211 6,43124
A0A1B3B0M4 217 5,92782
A0A4Y6EHN5 210 6,42050
A0A0E3X9U3 218 6,40566
A0A142KBE3 213 8,79067
A0A142KCB0 213 8,79067
A0A411B1T4 211 6,43135
A0A411B2T5 211 6,90693
A0A411B4N4 211 6,43135
A0A411BQU5 210 6,42061
A0A482J9V5 211 6,43135
A0A482JCW9 211 6,90693
A0A482JIE1 211 6,43135
A0A4Y6EFW5 211 6,10311
A0A4Y6EQL6 210 6,42061
A0A514A5Z4 211 6,10311
A0A515MJL0 210 6,42050
A0A5J6TCI8 213 9,00992
A0A7M1CNN0 210 6,09197
A0A7M1RR47 210 6,07998
A0A899IMQ8 211 7,00821
A0A9E7MCQ8 215 6,18484
A0A9E7MD50 211 7,00821
A0A9E7SZ35 210 5,82278
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33446
7bxFV
 3 37,9% 216 4.375E-49
2 phalp2_24159
2eCaD
 21 41,3% 186 1.245E-46
3 phalp2_17989
1fclU
 3 39,4% 185 7.019E-36
4 phalp2_12497
QM59
 22 28,8% 194 6.495E-25
5 phalp2_36860
7gDKs
 246 34,2% 190 1.208E-24
6 phalp2_30257
4gSoB
 83 29,9% 204 1.101E-21
7 phalp2_22551
1qQEX
 38 29,3% 184 3.850E-15
8 phalp2_7405
4FizF
 295 26,5% 211 1.100E-13
9 phalp2_24508
4NNU3
 22 27,7% 173 1.160E-10
10 phalp2_32384
yRbL
 80 24,5% 163 5.717E-09

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 8JOmU (218 AA)
Member sequence: A0A345MCG4 (213 AA)
1 218 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Gordonia phage Teatealatte
[NCBI] 		2283247 Demosthenesvirus > Demosthenesvirus katyusha
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH576976 [NCBI]
CDS location
range 39826 -> 40467
strand +
CDS
ATGAGTGTTGCGATCATCGGAGCGATCGCCCGCGAGAACGTCCGGCTCGGTGGCATCAGTCGGTACACGCAGGGCTGGGAGACGCGCGGCAACGGACAGCGCTCGAACTACGGCGGCATCCTGCTGCACCACACCGCAGGTGGGCGCAACGTCAACATCGACCAGATCTTGATTAACGGACGCTGGGACCTCGCCGGCCCGCTGTGCAACTTCTGCATCATGTATGATGGAGACATCGGCGTGATCGCGGCACACCCGGCGAACCACGCTGGTGCATCAGGTGGCTGGGATACCAGCCCCTTCGCCCGCACTGGACTGTTCAATAGTCAAATCATTGGTGTCGAGATTCAGTACCCCGGCACCGAGCCCATGGCACAGGTGCAGTACGAAGCCGCCAAGCGTCTAACCAACGCAACGCTGAATGTGCTGGGCAAGCCTCGCGACTATCGCTGGGCCAAGTTCCATCAGGGCACCAGCATCGAGGGCAAGTGGGATCCTGGCTACCACCCCTCTGGCAAGACCTACAGCATCGCACAGTTCCGCAAGGACTGCGCAGGCATGCCAGCAGCGGCGGGCGAGAACCCTGACTCCCCGACCTGGCAGGACAACAGGTTCCAGCTGCTCGGCCCGAAGGCTGCGTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8JOmU) rather than this protein.
PDB ID
8JOmU
Method AlphaFoldv2
Resolution 91.49
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50