Protein

Protein accession
A0A0A7S349 [UniProt]
Representative
8sEzo
Source
UniProt (cluster: phalp2_15548)
Protein name
Lysin A, protease C39 domain
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVEKVLPYDRSVVPQETPWDCGPAATQVVLNSRGIVVSESDLIREIGTTVNGTDYVGLITDRSLKRRLPDAKYTSVYIENDPPTAAQRDALWRNVVRSIDAGYGVVVNWVAPPSNYPRGVKGSVSPRYSGGTVYHYVACMGYDDNPALRAVWIADSGFQPQGYWISFDQLASLIPPKGYAYADAAPVGGGPAPSGPDPVDVLSQAMGGRLSRERYAALLPAVAQALAECQCGTVERVAMWCAQIGHESGGLYYMEEIADGSAYEGRLDLGNTQPGDGKRFKGRGPIQITGRSNYTRLSQWAFDKGLVPSPTFFVDDPAQLASDRYGFLGVVWYWTVARPQINSMCDANDLDGVTRAINGGLNGIDDRRARWDRCRAMGAALLAITTTQEDDPLSALSADEQRELLSLLRILASNRFVSRSPFRHLGEGPSETVAGFGLNTDGLNHAQYTIELARLGDPTHLALLREVASADGDSRYPDRQYDAKLAKRVLAEIEGAATPPAKPTTPSAPSEPAPEAPTSPVKASCALSAAGCVVADATSGGGCALSTDGTGKCVVAAATEAGK
Physico‐chemical
properties
protein length:563 AA
molecular weight:60007,6 Da
isoelectric point:5,17
hydropathy:-0,25
Representative Protein Details
Accession
8sEzo
Protein name
8sEzo
Sequence length
448 AA
Molecular weight
48651,44430 Da
Isoelectric point
6,03888
Sequence
MGYGTYGNPAVDSFVARKIRPDGFSTFRRDAVVVDPTNAVRTLMDAMGAGVSEQRYQQLFPAVADALRKCGCTSVKRIAMWCSQIGHESGGLRWMEEIADGSQYEGRTDLGNTQIGDGKRYKGRGPIQVTGRSNYTTLSKWAYAQGLVPSPTFFVDNPGQLATDTYGFLGVVWYWTVARPNINSMADSGNLEGVTRAINGGLNGFADRQQRYNNCISMGDRLLQLVASEPKEEGFLMALSAEEQVEIRDKVRQLWGAAFNLVPSKSRYGNPKDLWPSKDFDRNMDGFMYDIITEHDAALGDPAALRRVREAADKGDVIAQHFLEKLTAAPLPATPVSAVVSAPPANNVTCWNCSKHYPDVLPNCPFCGASQSPPSEPPAAIAQAQPVEASVGRHAAERVNPVVNEGLPAVDKSVVDQLTLLGQFNNQLPAEVSTAITQLIPVLKGLVK
Other Proteins in cluster: phalp2_15548
Total (incl. this protein): 71 Avg length: 483,7 Avg pI: 5,65
Protein ID Length (AA) pI
8sEzo 448 6,03888
2qOSX 495 4,74170
37UOZ 509 5,34482
4OIKI 368 4,85743
4dKnP 481 4,92654
6x5xN 476 5,40490
75mXc 485 4,86504
75r5P 477 4,81696
76XAi 479 6,64848
79I4I 487 5,31509
7AvKB 477 6,28374
7Avoe 477 6,15250
7AwP9 461 5,86314
7Awuh 477 6,15250
7AxbS 477 6,15250
7Axln 477 6,03519
7Axxr 461 5,86314
7PZ9y 489 5,92708
7Q0UN 494 6,24845
7Q1dz 477 6,15250
7Q1oW 470 6,03439
7XoZs 566 4,69083
7aXWI 477 6,15250
7hOqf 472 5,22921
7iJBl 489 6,15057
7jEga 477 6,15154
7pGjR 479 5,21813
7pNYj 472 5,16100
7pOhl 471 5,10161
7q5Qk 473 4,93012
7q5li 482 5,47782
7q7w5 488 5,05784
7q805 477 4,87419
7q8SH 481 4,88340
7qdK7 476 4,68043
7qfAN 465 5,24251
7qiKj 474 5,38000
7qiop 471 4,85197
7qlmA 482 5,38330
7r4fM 465 5,46697
7ubJK 434 4,96269
7zRXh 477 6,15250
867Gn 559 4,77160
87a1T 580 4,75404
8JrmF 476 5,98790
8Jrmg 477 6,15250
8Jrmh 477 6,03405
8Jrmi 477 6,15159
8Jrmj 477 6,03672
8Jrml 477 6,08407
8Jrmm 477 6,03519
8Jrmt 477 6,15250
8Jrmu 475 6,23492
8Jrna 461 5,97499
8Jrnj 477 5,92572
8Jrol 462 6,02473
8LVSm 477 6,15250
8M13e 475 6,38844
8MAYX 477 5,82318
8MCav 477 6,03342
8MDmC 477 6,15250
8MGdK 477 6,15250
8MKQB 477 6,15057
8MLma 477 6,03519
8MLqM 477 6,28374
8MWgo 477 6,15250
8MxQF 477 6,28454
8lGA4 584 4,79263
A0A222ZQH1 563 5,15145
A0A222ZQI6 572 5,15145
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24932
8Jrom
 307 43,4% 341 1.671E-133
2 phalp2_8241
7x5Zv
 42 46,5% 292 8.032E-89

Domains

Domains [InterPro]
Disordered region 1
Unannotated
Unannotated
Disordered region 2
Representative sequence (used for alignment): 8sEzo (448 AA)
Member sequence: A0A0A7S349 (563 AA)
1 448 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage Milly
[NCBI] 		1567473 Timquatrovirus >
Host Mycobacterium smegmatis str. MC2 155
[NCBI] 		246196 Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KP027206 [NCBI]
CDS location
range 23083 -> 24774
strand +
CDS
TTGGTTGAGAAGGTTCTGCCTTACGACCGCTCGGTCGTGCCGCAAGAGACACCGTGGGACTGCGGCCCGGCCGCAACGCAGGTCGTGCTCAACTCGCGCGGCATCGTCGTCAGCGAGTCCGACCTGATCCGCGAGATTGGGACGACCGTCAACGGCACCGATTACGTCGGGCTGATTACCGACCGCTCACTCAAGCGGCGCCTGCCCGACGCCAAGTACACCTCGGTGTACATCGAGAACGACCCGCCGACCGCGGCGCAGCGCGACGCCCTGTGGCGCAACGTGGTTCGCTCGATCGACGCCGGGTACGGCGTGGTGGTCAATTGGGTCGCCCCGCCCTCGAACTATCCGCGCGGCGTCAAGGGCTCGGTGAGCCCCCGCTACAGCGGCGGCACCGTGTACCACTACGTCGCTTGCATGGGCTACGACGACAACCCGGCCCTGCGCGCAGTGTGGATCGCCGACAGTGGCTTTCAGCCGCAAGGGTATTGGATCAGCTTCGACCAGCTCGCCTCGCTGATCCCGCCGAAGGGCTACGCCTACGCCGACGCTGCCCCGGTGGGCGGCGGCCCGGCGCCGAGCGGCCCCGACCCGGTCGACGTGCTGTCTCAGGCTATGGGCGGCAGGTTGTCTCGCGAGCGTTACGCCGCGCTGCTGCCCGCGGTGGCCCAGGCGCTCGCCGAGTGCCAGTGCGGCACCGTCGAGCGTGTCGCAATGTGGTGCGCGCAGATCGGGCACGAGTCGGGCGGCCTGTACTACATGGAGGAAATCGCCGACGGCAGCGCCTACGAGGGCCGCCTCGACCTGGGCAACACGCAGCCGGGCGACGGTAAGCGGTTCAAGGGCCGCGGCCCTATCCAGATCACCGGCCGGTCGAACTACACGCGCCTGTCGCAATGGGCGTTCGACAAGGGCCTCGTGCCGTCGCCGACGTTCTTTGTCGACGACCCGGCGCAATTGGCAAGCGACCGTTACGGATTCCTGGGCGTCGTCTGGTACTGGACAGTGGCCCGGCCGCAGATCAACAGCATGTGCGACGCCAACGACCTTGACGGCGTCACGCGGGCGATCAACGGCGGGCTGAACGGCATCGACGACCGGCGCGCTCGCTGGGACCGCTGCCGCGCAATGGGCGCGGCGTTACTCGCAATCACGACGACACAGGAGGATGACCCGTTGTCTGCCCTATCCGCTGACGAGCAGCGCGAACTGCTCTCGCTGCTGCGCATTCTCGCGAGCAACCGTTTCGTGAGCCGCAGCCCGTTCCGCCACCTCGGCGAGGGGCCGAGCGAAACTGTCGCCGGGTTCGGGCTCAACACCGACGGCCTCAATCACGCGCAGTACACGATCGAGCTTGCGCGCCTGGGCGACCCGACGCACCTCGCCCTGCTGCGCGAGGTCGCGAGCGCCGACGGCGACTCGCGCTACCCCGACCGGCAGTACGACGCCAAGCTCGCCAAGCGCGTGCTCGCCGAAATCGAGGGCGCTGCAACGCCACCGGCCAAGCCGACCACGCCGAGCGCCCCGAGCGAGCCCGCCCCCGAGGCGCCCACGTCGCCGGTCAAGGCGTCCTGTGCGCTGTCTGCGGCCGGGTGCGTGGTGGCTGACGCGACCTCGGGCGGTGGCTGCGCCCTGTCCACCGACGGCACCGGCAAGTGCGTCGTCGCCGCCGCGACCGAAGCTGGGAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0006508 proteolysis biological process None (UniProt)
GO:0008233 peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8sEzo) rather than this protein.
PDB ID
8sEzo
Method AlphaFoldv2
Resolution 76.96
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50