Protein

Protein accession
A0A222ZHQ8 [UniProt]
Representative
6W23o
Source
UniProt (cluster: phalp2_36825)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAQRLWPLPRDGYELTSGFGPRWGAQHSGLDLAAPDGTPFYACQAGTVQFIGSATGYGQWLVIDSSDDEGSGCVEYGHMWNARATGLSVGDHVEAGQLIGYIGSNGQSTGPHLHITVWERGYNSVRIDPEVWLASAGFPGEAVTAPKPSTGEPIWGIDVSNHQGNFDFAAAKAEGFVFATHKVTEATGYRDPYWARARQEMEKHFPGRWGGYVFCRTNTDPVTEARYFYDAVGGDTSVPVQIDYEDTTNGGSGADLFNRVRAYQDLGFRLLPIYIPRWFWRDHMGSPDLSGLPVPIWNSHYARGVDYASNLYAKHGEKSDAWSDMGGKPVSILQFSETAMVAGKLIDVNAFRGTEAELDELFSGQELPMSAVQEIKDYIDIRVTNPIGSDVKDLREQACGQGARDAGQYNGWPQLGNRTIADALAVIGVALKIEGFFDPRSIG
Physico‐chemical
properties
protein length:443 AA
molecular weight:48409,1 Da
isoelectric point:4,91
hydropathy:-0,36
Representative Protein Details
Accession
6W23o
Protein name
6W23o
Sequence length
409 AA
Molecular weight
43757,32740 Da
Isoelectric point
6,14886
Sequence
MKKGAYSISSGFGPRSGGFHYGLDFAAKDGTPFYACQAGTVQYIGAASGYGQWIVIDSSDAEGSGCVEYGHMWDAFATDLKVGSKVKAGQLMGYVGSNGQSSGPHLHITVWEYGYGGTRIDPAKWLAGRGYPGNTPVVSAKQEAPVAAIPNPITRTQISPNRHSGGRDVDWIVIHTQEGSGTAASIVNYLCRPAAQVSYNAVCDDRETVLVVPWDQNPWSATNANTRGDHILMAGSFASWSRGKWLSPDASDGKNEDLQLTRTAALVAWRCAVRDIPIRYVGGKFPTTPGVCGHRDFGSWGGGHTDPGPNFPWDELISRAISIYNGGKDWLAMATMAEVEALIYKCLKVYVGPIGSDVKDIRQQLTGGRDAGEYGGFEQGGNRTLYDLVAAEAAKSGVPGTRDTMEEQK
Other Proteins in cluster: phalp2_36825
Total (incl. this protein): 94 Avg length: 474,9 Avg pI: 6,67
Protein ID Length (AA) pI
6W23o 409 6,14886
16rNW 404 7,83976
1iXn1 422 7,34453
1j0DK 432 8,28330
24230 432 5,96698
3zvcd 415 6,32410
4USF1 432 9,35135
6Ra25 420 5,54200
7AFG8 606 5,93765
7AFLp 455 6,87720
7AG9X 606 5,62015
7AGMJ 606 5,78976
7AGe9 606 5,76321
7AH3P 606 5,78976
7AJzx 453 6,42664
7AuN9 527 6,99884
7AuOu 537 6,22833
7AuSz 537 6,22833
7AuZn 543 6,02422
7Ax6s 527 6,99884
7Jp4q 355 6,48973
7PKrp 544 6,27607
7Q0yN 438 6,34132
7VVqW 560 4,82923
7b4Yd 615 5,65721
7cFuD 411 6,59346
7dhi3 428 8,96273
7gOsB 427 5,59201
7gVgd 412 6,13085
7iKmF 455 8,20955
7j4LS 411 5,01550
7jxoo 451 8,62002
7omqk 423 9,05396
7otvG 434 8,72904
7owg9 414 5,18118
7pO9x 412 5,93038
7qJoh 449 7,77832
7r45t 453 6,86566
7ssLr 414 6,00830
7tGpV 425 7,15560
7ulim 411 5,15964
7urj3 432 5,94504
8JOkC 442 8,61067
8JOkP 455 8,30999
8JOkW 443 6,13733
8JOkt 451 8,50701
8JOl1 455 8,30999
8JOlA 456 8,30999
8JOli 455 8,30999
8JOlt 451 8,81336
8JOly 442 8,31006
8JOm0 442 8,31006
8JOm1 451 8,81336
8JOm6 443 8,61074
8LChI 605 5,98613
8LCj2 525 6,11465
8LCks 606 5,84807
8Lm19 603 5,76083
8LyEf 544 6,42749
8LyFz 536 6,78666
8LyGZ 531 6,65263
8LyIn 538 6,19809
8LyMD 536 6,62739
8LyO1 535 6,46995
8Lzsj 441 8,75656
8MDc7 527 8,19981
8MEKS 540 7,75513
8MEMh 527 6,49769
8MI2I 582 6,20400
8N0K2 430 7,15594
fKif 446 6,37366
j8YB 377 7,31588
A0A385UL34 520 7,16964
G9FHQ8 437 5,06369
G8I883 520 6,42584
A0A0F6WEB0 520 6,27380
S5YDQ1 517 7,15105
A0A1I9S7S4 443 5,00470
A0A223FZJ1 443 4,93700
A0A2Z4Q4Y3 443 4,85987
A0A0K2CLX4 443 4,82690
A0A2Z4Q8H8 443 5,03789
A0A142KAY0 430 7,15594
A0A1C9LX78 443 4,86618
A0A1L6BYY2 520 6,27380
A0A222ZI76 443 4,95564
A0A2Z4Q4F2 446 4,93353
A0A2Z4Q627 443 4,90870
A0A5P8DCB2 425 7,12900
A0A6G6XSC9 443 5,05722
A0A7M1CQE6 520 6,42482
A0A2L1IZL4 363 7,78631
A0A9E7MF48 430 7,13514
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28062
7ebmV
 12 33,1% 404 2.788E-92
2 phalp2_23662
8MT9Q
 13 58,5% 268 1.441E-89
3 phalp2_2847
8LyZr
 374 34,7% 368 1.635E-72
4 phalp2_36852
7d3iJ
 93 30,1% 299 4.754E-59
5 phalp2_18569
7cxQw
 45 28,9% 266 3.204E-48

Domains

Domains [InterPro]
PET_M23
Ami2
Unannotated
Disordered region
Representative sequence (used for alignment): 6W23o (409 AA)
Member sequence: A0A222ZHQ8 (443 AA)
1 409 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510, PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Rhodococcus phage StCroix
[NCBI] 		2015832 Rerduovirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF324900 [NCBI]
CDS location
range 1792 -> 3123
strand +
CDS
ATGGCACAGCGACTTTGGCCGCTCCCCCGCGACGGATACGAACTCACTTCCGGTTTCGGTCCCCGATGGGGAGCCCAGCATTCCGGTCTTGATCTCGCAGCCCCGGACGGTACTCCGTTCTACGCCTGCCAGGCCGGTACGGTTCAGTTCATCGGCTCTGCAACTGGTTACGGCCAGTGGCTGGTTATCGACTCGTCCGATGACGAAGGCAGCGGCTGTGTTGAGTACGGCCACATGTGGAACGCCCGAGCTACCGGCCTTTCGGTCGGTGACCACGTCGAGGCCGGCCAACTGATCGGTTATATCGGCAGCAACGGACAGTCCACTGGACCCCACCTGCACATCACGGTCTGGGAACGCGGATACAACAGTGTCCGTATCGACCCAGAGGTCTGGCTGGCATCTGCCGGCTTCCCTGGTGAAGCCGTGACAGCTCCCAAGCCGTCCACCGGTGAGCCGATCTGGGGTATCGACGTTTCCAACCACCAGGGCAACTTCGACTTCGCTGCCGCGAAGGCCGAGGGCTTCGTGTTCGCCACTCACAAGGTGACAGAGGCTACCGGCTACCGCGACCCGTACTGGGCTCGCGCTCGCCAGGAGATGGAGAAGCACTTCCCAGGTCGCTGGGGTGGTTATGTGTTCTGCCGCACCAACACTGACCCCGTAACCGAGGCACGGTACTTCTACGACGCAGTCGGCGGTGACACTTCGGTGCCGGTCCAGATCGACTACGAAGACACCACGAACGGTGGCAGCGGCGCTGACCTGTTCAACCGTGTCCGTGCGTACCAGGATCTCGGATTCCGGCTACTGCCGATCTACATTCCCCGGTGGTTCTGGCGGGATCACATGGGCAGCCCGGATCTTTCGGGGCTGCCGGTTCCGATCTGGAACTCCCACTACGCACGAGGCGTGGACTACGCGTCCAACCTCTACGCCAAGCACGGTGAGAAGTCCGACGCATGGTCCGACATGGGCGGTAAGCCCGTGAGCATTCTCCAGTTCTCGGAGACGGCGATGGTCGCCGGCAAGTTGATCGACGTAAACGCCTTCCGAGGCACAGAGGCTGAACTTGACGAACTGTTCAGCGGACAGGAACTTCCCATGAGCGCAGTGCAGGAAATCAAGGACTACATCGACATTCGCGTCACGAACCCGATCGGTTCCGACGTGAAGGATCTCCGCGAACAGGCTTGCGGCCAAGGTGCCCGCGATGCCGGCCAGTACAACGGTTGGCCGCAGCTCGGAAACCGAACCATCGCAGATGCTCTCGCCGTGATCGGCGTGGCGCTCAAAATCGAAGGATTTTTCGACCCACGAAGTATCGGATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000b949121_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (6W23o) rather than this protein.
PDB ID
6W23o
Method AlphaFoldv2
Resolution 87.23
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50