Protein

Protein accession
A0A2I5ARC6 [UniProt]
Representative
4piAe
Source
UniProt (cluster: phalp2_27320)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MSNDKAITLEQLFRYKKPWGQQPHQDAAVIELEEDLAANGYAVAMRRDRSWFKAWSQDGKQHDPIYLAPALRRSSRRSRVASWRPTQTLDLEVCQNYHWLGHNERAWCSSARKGDTISQALADELLRAEILRIAAELHEIIPAAAKWGGNQQAAFISWAYNVGLGAVKDSTLRRRINAGESAQVVIPQELPKWDKANGAALPGLTRRRAAEVALFMGAAPSLPKQQAPRFTPSSSLSTRVAPHITYGELCLGEERRRFVNQGQCDIAIELCAFIEKARAQFGNQPIIITSAHRPKAVNDAVGGAVDSEHLFKPGSGAIDWYIKDVSVKLVQDWCDLNWPFSLGYGAPRGFVHLGIRAGRPRPRVRWNY
Physico‐chemical
properties
protein length:368 AA
molecular weight:41151,3 Da
isoelectric point:9,53
hydropathy:-0,41
Representative Protein Details
Accession
4piAe
Protein name
4piAe
Sequence length
405 AA
Molecular weight
44187,44680 Da
Isoelectric point
8,46078
Sequence
MTYATFRAAAEHVARAGTITPHQLAAWEAAWEAASDEQRREFTELWRAQGSPAAPAPVAGWLAPARTIVREFEGCHLKAYLCPANVWTVGWGSTTIAGKGVREGQSITQAQADAQLDADLQRFYDALARAIPAVAGWPPNRAAALVSWTYNVGVGAMQDSTLRRRILAGEDPAQVVAAELPRWNKADGKELPGLTRRRAAEVALFVGQQLQQSAPAPTPAERRQWVTEIKALNLSQPDASTCQAAAIGMGVGDRDVAGIRRKLVARGAAGDPDVMAAVIRSYNRPYILDKNASLAKCYEWLKAGEFLITHGWFTNSGHVICLDGLKATPEPGSYVFDVKDPWSEFNVQTWRYDLGSKFFDGFYSDLLIYATCVASFSAGGAREIYQRGKVDASRGGMWVHRFLTS
Other Proteins in cluster: phalp2_27320
Total (incl. this protein): 24 Avg length: 412,7 Avg pI: 8,72
Protein ID Length (AA) pI
4piAe 405 8,46078
1X56B 394 9,20604
2Xpv7 426 9,02623
4AbEE 384 8,48522
4D8vl 437 8,95409
4DS7d 388 8,16120
4ab4v 427 8,80111
4mCIG 427 9,18637
4pnVJ 426 9,25742
4zGRf 414 9,17187
4zpz5 437 8,45530
50tSA 426 9,06479
51a8l 394 9,05795
564fd 394 8,24398
59wsV 426 8,76849
5CXSw 409 7,66720
5CYyq 427 9,29384
5CpLj 412 6,72004
5b4OR 394 8,56986
5iSmW 427 8,63472
5uoCU 437 8,15069
5wlPh 427 9,17129
5zxpp 398 9,35522
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26726
323et
 12 19,3% 403 7.913E-33
2 phalp2_32013
5m77S
 660 29,6% 368 1.890E-29

Domains

Domains [InterPro]
Unannotated
GH24
Unannotated
Representative sequence (used for alignment): 4piAe (405 AA)
Member sequence: A0A2I5ARC6 (368 AA)
1 405 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Synechococcus phage S-LBS1
[NCBI] 		2008320 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG271909 [NCBI]
CDS location
range 20445 -> 21551
strand +
CDS
ATGAGCAACGACAAGGCGATCACCCTCGAGCAGCTGTTCCGCTACAAAAAACCCTGGGGACAGCAGCCGCACCAGGATGCAGCGGTGATCGAGCTCGAGGAGGATCTGGCCGCCAATGGCTATGCGGTAGCAATGCGCCGTGATCGCTCCTGGTTCAAGGCGTGGAGCCAGGACGGCAAGCAGCATGATCCGATCTACCTGGCACCAGCTCTCAGAAGATCATCAAGGCGTTCGAGGGTTGCAAGCTGGCGGCCTACCCAGACCCTGGATCTGGAGGTCTGCCAAAATTACCATTGGCTGGGGCACAACGAGCGTGCATGGTGCTCCAGTGCGCGAAAGGGCGACACAATCAGCCAGGCCCTGGCCGATGAACTGCTCCGCGCTGAGATCCTGCGCATTGCTGCGGAACTCCATGAGATCATCCCAGCTGCTGCCAAGTGGGGCGGCAACCAGCAGGCAGCATTTATCTCATGGGCCTACAACGTGGGCCTAGGCGCTGTGAAGGACAGCACGCTGCGGCGGCGCATCAATGCAGGCGAATCAGCGCAGGTAGTCATCCCGCAGGAGCTGCCCAAGTGGGACAAGGCCAATGGCGCTGCACTGCCCGGCCTGACCCGGCGGCGGGCTGCTGAGGTGGCGCTGTTCATGGGTGCTGCTCCGTCGTTGCCAAAGCAGCAGGCGCCACGCTTCACGCCATCGTCTTCGCTGAGCACCAGGGTGGCGCCGCACATCACCTACGGCGAGCTATGTCTTGGCGAGGAACGTCGCCGCTTCGTCAACCAGGGTCAGTGCGACATCGCCATCGAACTCTGCGCTTTCATTGAAAAAGCCAGAGCACAATTCGGCAACCAGCCAATCATCATCACGTCTGCTCATCGGCCAAAAGCAGTGAACGATGCTGTCGGTGGTGCCGTAGATAGCGAGCATCTCTTCAAGCCAGGATCGGGCGCGATCGACTGGTACATCAAAGATGTCTCGGTCAAACTGGTGCAGGACTGGTGCGACCTGAATTGGCCCTTCTCGCTTGGCTACGGGGCGCCGCGTGGGTTTGTGCATCTAGGCATTCGTGCTGGTCGGCCTCGCCCTCGCGTGCGTTGGAATTACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
upi000ca17418_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4piAe) rather than this protein.
PDB ID
4piAe
Method AlphaFoldv2
Resolution 86.92
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50