Protein

Protein accession
A0A218KD91 [UniProt]
Representative
2VKgf
Source
UniProt (cluster: phalp2_24235)
Protein name
N-acetylmuramoyl-L-alanine amidase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGTYNVHGGHNSIVQGANYGSRKEHVMDRQVKDALISKLRSLGHTVYDCTDETGSTQSANLRNIVAKCNAHRVDLDISLHLNAYNGSANGVEVCYYDQQALAAKVSKQLSEDIGWSNRGAKPRTDLYVLNSTSAPAILIELGFIDNESDMAKWNVDKIADAICYAITGQRAGSTGGSTGGSTGGSTGGGGYDSSWFTPQNGVFTANTTIKVRSEPSVNAAHLRTLYSGGTFTYTSFGMEKDGYVWIKGVDGTYVATGETRDGKRISYWGTFQ
Physico‐chemical
properties
protein length:272 AA
molecular weight:29212,9 Da
isoelectric point:6,65
hydropathy:-0,42
Representative Protein Details
Accession
2VKgf
Protein name
2VKgf
Sequence length
283 AA
Molecular weight
32494,85280 Da
Isoelectric point
4,90960
Sequence
MGNIIDISKWNGNIDWDAAKPNIDFIIARVQDGSNYVDPKYKEYIQEMKDRNISFGNYAFCRFVSEEDARIEARDFYNRGDKSATVWVADVEVKTMDNMKAGTQAFIDELRKLGCQKVGLYVGHHMYEPFGMNQVSCDFVWIPRYGGNKPIYPCDIWQYTETGYVEGIGKCDLNVLNGDKSLDWFTGEEEKVQEQKQESLAYDSSWFTKQDGKFIANTSIKVRREPSVNSEHVRTLQPNGDFSYESYGYEKDGYVWLKGVDGLYVASGETVNGERVSTWGKFI
Other Proteins in cluster: phalp2_24235
Total (incl. this protein): 225 Avg length: 277,2 Avg pI: 6,01
Protein ID Length (AA) pI
2VKgf 283 4,90960
1af9u 269 5,99477
1bXbZ 272 5,69449
1cgi3 272 7,67607
1d7U9 265 5,46600
1jSNz 269 5,49897
1kkZ0 269 5,97562
1r3Lo 318 9,33588
2LAXC 282 6,00779
2UtFQ 282 4,96940
2UuNH 282 4,96940
2UvXt 282 5,04363
2UvtB 280 5,58093
2Uyhv 282 5,03641
2Uyzm 282 4,85640
2VEQN 282 4,97690
2VFj3 280 5,56843
2VHET 282 4,97690
2VOho 282 4,80695
2VOnM 280 5,42081
2WCqb 282 5,03641
2WDQ9 280 5,42081
2X3tD 280 4,74290
2YjYo 269 5,99642
2YkF1 266 6,16285
2YkRf 280 5,74315
2YlcI 263 6,95672
2ZMY5 272 5,70012
36Fo7 280 5,42081
36FoI 269 5,27832
39AFL 280 5,42081
39pQa 282 4,90960
39q2p 348 7,68585
39wTD 280 5,42081
39zNz 282 4,91057
39zii 281 5,78402
3LleL 269 5,98636
3LltY 323 9,29120
3LlyX 266 5,32584
3Lmc9 288 5,18806
3Lmjp 272 6,22889
3a6Sk 265 5,10462
3eGyr 277 5,88286
4DXjK 276 5,10684
4E5jF 272 5,32220
4E6B8 274 5,20858
4EqLQ 283 5,29253
4EqPo 281 6,33461
4Er2D 283 5,74644
4UvOE 269 5,31919
72gs4 268 6,12056
72iAO 268 5,86291
72ivF 266 5,63959
72iwW 269 6,33041
72jep 272 6,66275
72pdW 269 5,10479
72roE 272 6,44920
72rot 269 5,97403
73A6M 269 6,12090
73HbP 272 6,45307
73onG 268 5,86797
73wNN 269 5,22279
73wNP 272 6,12801
73wUq 276 6,33075
742pq 272 5,73002
746Qv 272 6,90676
74jAI 272 5,97954
76MoK 272 5,70774
77NY3 265 6,82468
78nD2 272 5,98636
79ydt 272 6,53543
7AxAC 265 5,35573
7AxBn 265 5,24564
7BA8W 272 5,86149
7BAqW 269 6,83468
7BAsf 273 6,82877
7BBJ7 272 6,45307
7BBuB 277 6,14347
7BhVN 268 5,29946
7Bvu5 266 7,66186
7Bvu7 278 8,48883
7PppQ 272 6,82712
7QC76 276 5,63532
7c4Qb 277 6,01944
7c4pp 272 6,45312
7cSVz 269 5,22279
7cifj 272 6,34075
7dJpf 272 6,12437
7dJwD 272 6,45182
7di2Q 339 5,32885
7dkrP 341 5,02351
7dlBe 272 6,44153
7dzb1 269 5,65380
7e32P 266 6,09822
7e3xk 269 6,33882
7e5gX 281 7,61577
7e9b1 269 7,61758
7e9e4 272 6,24072
7eisG 266 6,95712
7eqN4 272 6,53088
7ercr 277 5,71973
7fBCU 269 6,83406
7fBzI 269 6,33263
7hqcA 277 5,98523
7hqdk 272 5,86149
7hwVi 269 6,44312
7hwVj 269 5,35102
7jLMH 265 5,45730
7ji9Y 272 5,97585
7jiJO 269 6,44323
7jiff 272 5,36761
7jiga 272 6,33245
7jimf 285 5,58275
7kmqH 272 5,86666
7kyOb 269 5,36062
7lt9X 268 6,32853
7ltBz 269 6,90454
7ltDw 272 5,70774
7ltc5 269 5,12576
7luEm 269 6,33882
7luww 269 6,33882
7lvzJ 269 6,34382
7mwFU 272 6,23907
7nErp 262 6,22480
7oqbh 280 6,60147
7ov2t 269 6,90363
7oviO 269 5,42815
7p1Xt 273 6,43829
7rGDP 340 5,18181
7rGDp 339 4,90801
7rGWA 277 5,17396
7rGkM 277 5,01743
7rklo 281 7,65203
7rlJ7 281 6,32291
7rpNx 272 6,33979
7u5zF 269 5,85785
7ulHL 269 6,32853
7v1Rz 268 5,97761
7vGtE 322 9,37675
7vR5f 269 5,98278
7vt5t 277 6,50519
7xMeh 272 5,85381
7xNaJ 272 6,53725
7y8dy 273 5,26763
7yCCL 272 5,50550
7yCQK 265 6,51661
7yTEZ 272 6,44227
7yTF2 269 5,34368
7yTUN 269 5,97403
7ykOo 331 5,22586
7zdRg 269 5,20420
7zdSi 269 5,78203
7zdUt 272 6,22895
8JpG3 368 7,50607
8K2uA 272 6,23913
8K2uk 265 5,97778
8K2ut 265 5,33863
8K2uw 272 6,33558
8K2v7 284 5,80021
8K2va 262 6,22480
8LSn6 284 5,35596
8LZiv 285 5,50124
8MDyy 265 5,50943
8MQXZ 265 5,71280
8MssW 265 5,33607
QIgv 267 8,41301
b8eS 269 5,81312
d02j 265 5,56308
eNPQ 326 5,20261
fQj 265 6,43101
fuDw 282 4,84691
M4HNC8 272 6,37645
J9PQX3 285 5,50124
A0A4P8N7H3 276 6,33075
I7IDG0 272 6,90676
A0A0S2MUC0 272 6,64706
A0A3T0IIX9 265 5,35573
A0A3T0IJ07 265 5,24564
D2XR33 269 6,33882
A0A1B1PAK9 265 5,45730
A0A219UQL8 272 6,37196
A0A1I9S5W9 272 6,65246
G9J241 272 6,64814
A0A0K2D0M9 272 6,37071
A0A0E3DEU5 272 7,04198
A0A1B1P783 272 6,23913
A0A3G8F584 265 5,97778
A0A1B1PAF8 265 5,33863
A0A0E3D9B5 284 5,80021
A0A1Z1LZN8 262 6,22480
A0A160LKP9 265 5,37398
A0A385E984 364 5,54853
A0A3G8F6I4 364 5,67284
X2JN49 284 5,35596
A0A386KSS7 265 5,50943
A0A7M1RRG4 265 5,71280
A0A1X9SHN6 265 5,33607
A0A024B030 364 5,66840
A0A1B1PAP0 265 5,97778
A0A1I9S6P7 265 5,71064
A0A222Z5F8 364 5,54711
A0A223LI94 265 5,50045
A0A223LID0 265 5,70313
A0A346TNH1 272 7,04271
A0A385EAG5 284 5,53466
A0A3Q8CHX2 272 6,37196
A0A3T0IJ27 265 5,24564
A0A482IGD8 365 9,88051
A0A514AAM8 265 5,70313
A0A5B9MZ90 272 6,65246
A0A5B9NL58 272 6,37889
A0A6B7MBG1 276 6,44488
A0A7G8AKD5 282 6,32126
A0A7T7GT79 265 5,50045
A9QTG1 288 5,95891
A0AAE9LW88 246 6,23469
A0A8F2EUX1 265 5,52432
A0A9E7NPV6 212 5,46850
A0AAE9LV70 293 6,71299
A0AAE9MRV7 269 6,11732
A0AAE9YA49 281 5,47896
A0AAE9CBN4 271 6,65234
A0AAU9EJV5 272 6,64587
D6QWN3 272 7,04561
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11865
7owpA
 74 51,4% 241 5.610E-102
2 phalp2_32227
7cHL2
 31 43,8% 244 1.241E-81
3 phalp2_32637
21xEV
 86 54,1% 205 1.700E-81
4 phalp2_354
72wcG
 31 46,3% 207 9.084E-76
5 phalp2_12693
24JaA
 16 42,3% 215 5.592E-49
6 phalp2_2120
3gPQA
 3 38,3% 214 2.234E-44
7 phalp2_29128
7804q
 3 25,9% 274 2.156E-32
8 phalp2_16055
3TLHo
 2 31,3% 217 1.371E-31
9 phalp2_11344
7rGpn
 1 28,4% 274 1.613E-26
10 phalp2_39103
2m4j4
 107 34,0% 197 6.324E-25

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 2VKgf (283 AA)
Member sequence: A0A218KD91 (272 AA)
1 283 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage PBC6
[NCBI] 		1673872 Herelleviridae > Tsarbombavirus >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KT187252 [NCBI]
CDS location
range 8624 -> 9442
strand +
CDS
ATGGGAACATATAACGTACACGGTGGGCATAACTCAATCGTACAAGGTGCTAACTACGGTAGCAGAAAAGAACACGTTATGGATCGCCAGGTTAAAGATGCTTTAATTAGCAAGCTTCGTAGTCTTGGTCACACAGTTTACGACTGCACAGACGAAACAGGTTCTACACAAAGCGCTAACCTACGTAACATCGTAGCGAAATGTAATGCTCATCGAGTAGACTTAGACATTTCATTACACTTAAATGCGTACAACGGTTCTGCTAACGGAGTAGAAGTTTGCTACTACGACCAACAAGCTTTAGCTGCTAAAGTGTCTAAACAGCTTTCTGAAGACATCGGATGGTCTAACCGTGGAGCTAAACCTCGTACAGACCTTTACGTATTAAATAGCACATCTGCACCTGCTATCCTAATCGAGCTTGGTTTCATCGATAACGAAAGCGACATGGCTAAATGGAATGTAGATAAAATCGCAGACGCTATCTGCTACGCTATCACAGGACAACGTGCAGGTTCTACGGGCGGAAGTACAGGGGGTTCTACAGGCGGAAGCACTGGTGGAGGTGGATACGATTCTAGTTGGTTCACACCACAAAATGGTGTATTCACAGCTAACACTACAATCAAAGTGAGAAGCGAACCAAGTGTAAATGCAGCACACCTTCGCACTCTATACAGTGGTGGAACATTCACGTATACTTCATTCGGAATGGAGAAAGACGGTTACGTTTGGATCAAGGGAGTAGATGGTACATACGTTGCAACAGGTGAAACTCGTGACGGTAAACGTATCTCTTACTGGGGAACTTTCCAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0071555 cell wall organization biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A218KD91
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
upi000b5f7f35_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2VKgf) rather than this protein.
PDB ID
2VKgf
Method AlphaFoldv2
Resolution 94.59
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50