Protein

Protein accession
A0A0M4S5S0 [UniProt]
Representative
4JYw2
Source
UniProt (cluster: phalp2_35853)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVARKLVGPIAAMLVVGAAGTGLIKQSEGTRYKSYLDEAGIPTICTGHTGPEVKLGQYATKEECDKLLKQDLLRHSAAVSRCVNYTLTQYQYDAVVSFTFNVGETAFCRSTMARKINAGDLQGASAEFPKWNKVRINGKLVVSPGLSARRERERELFEGKVPK
Physico‐chemical
properties
protein length:163 AA
molecular weight:17841,4 Da
isoelectric point:9,43
hydropathy:-0,26
Representative Protein Details
Accession
4JYw2
Protein name
4JYw2
Sequence length
218 AA
Molecular weight
24443,55740 Da
Isoelectric point
9,34458
Sequence
LFDDCQTVPELRARYTALATRHREDSELLGIINEDYLRRLEAVTEAAIGEELRDLGVVRTSKARGRPRLRHINEAGLNLLKGREQLRLKAYRDQGGVLTIGWGHTGADVKEGMTITEAKAVELLKQDLSAAERAVSDLVYTALSDNRFDAVVCLVFNIGRSAFSQSTMRKCLNAADWKGASAQFPVWNKVRDKKTGKLFVSNGLVNRRREERALFDTP
Other Proteins in cluster: phalp2_35853
Total (incl. this protein): 2 Avg length: 190,5 Avg pI: 9,39
Protein ID Length (AA) pI
4JYw2 218 9,34458
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33221
5jbqV
 447 53,3% 148 2.317E-43
2 phalp2_6830
8n5Jv
 121 53,3% 148 2.081E-42
3 phalp2_2632
6RhYr
 14867 52,9% 151 3.494E-41
4 phalp2_28113
7zmZV
 50 49,3% 148 4.699E-38
5 phalp2_2498
5GMvl
 297 50,6% 146 8.788E-38
6 phalp2_32792
2snIK
 45 50,0% 144 4.086E-34
7 phalp2_4532
3QBcV
 9 45,2% 146 1.426E-33
8 phalp2_26378
1q5mp
 207 45,5% 147 4.974E-33
9 phalp2_4451
31DIk
 4919 46,7% 152 1.269E-32
10 phalp2_34878
4dXDH
 390 45,3% 150 6.046E-32

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): 4JYw2 (218 AA)
Member sequence: A0A0M4S5S0 (163 AA)
1 218 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Caulobacter phage Percy
[NCBI] 		1701809 Autographiviridae > Percyvirus > Percyvirus percy
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KT381879 [NCBI]
CDS location
range 43672 -> 44163
strand +
CDS
GTGGTAGCCCGTAAGCTAGTCGGCCCCATCGCAGCAATGCTTGTGGTGGGTGCCGCTGGCACGGGTCTGATCAAGCAGTCTGAGGGTACTCGCTACAAGTCCTATCTGGATGAGGCGGGTATCCCCACTATCTGCACGGGCCACACCGGTCCCGAGGTCAAGCTCGGCCAGTATGCTACCAAGGAGGAGTGCGACAAACTCCTCAAACAAGACCTCCTGCGACATAGTGCCGCAGTGAGCAGGTGTGTTAACTATACCTTAACCCAGTACCAGTATGATGCTGTGGTCAGCTTCACCTTCAACGTCGGGGAAACCGCGTTCTGCCGCTCTACTATGGCGCGCAAGATCAACGCAGGGGACCTCCAGGGTGCATCGGCCGAGTTCCCGAAGTGGAACAAGGTGCGGATCAACGGTAAGCTGGTCGTTTCCCCGGGCCTGAGCGCCCGCAGGGAGCGAGAAAGGGAGCTATTCGAGGGGAAGGTACCCAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016020 membrane cellular component None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0020002 host cell plasma membrane cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (4JYw2) rather than this protein.
PDB ID
4JYw2
Method AlphaFoldv2
Resolution 86.72
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50