Protein

Protein accession
A0A2H5BQB7 [UniProt]
Representative
4CbTI
Source
UniProt (cluster: phalp2_3550)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MRTNNIDAIKEHEGLRLVAYLDSVGVWTIGYGDTGPDVVKGLTITKEEAEKRLRKRLVEFEGYVNTYVKVPLKQHQFDALVSLVYNIGPANFKTSTLLKKLNAGDYIGAADQFLVWDKGRVDGKLVVIKGLANRRAKERKQFLGE
Physico‐chemical
properties
protein length:145 AA
molecular weight:16308,6 Da
isoelectric point:9,49
hydropathy:-0,32
Representative Protein Details
Accession
4CbTI
Protein name
4CbTI
Sequence length
244 AA
Molecular weight
26711,85140 Da
Isoelectric point
7,78818
Sequence
MSYSLKILNPTWFKQDTEQSVVLSIAQKVLVDAGQIFPISSFAPSQSQHVKFSLGKNDQGKQIALQSKNTWYAYSPHVQMLKDGKPFSAADVPRSGAIGAAGLELIKSFEGCVLDAYQDVVGVWTIGYGSTGAHVYPGQSITQEQAEALLKKDLERFEAAIGWMVTAPINGNQRDSLISFAFNLGEGALQGSTLLWRLNQGDYAGAADQFPRWANAGGEQLAGLVRRRKAERSLFLSQNYTQYL
Other Proteins in cluster: phalp2_3550
Total (incl. this protein): 96 Avg length: 158,6 Avg pI: 6,15
Protein ID Length (AA) pI
4CbTI 244 7,78818
13Usf 214 9,95684
1FWMr 150 5,12258
1m4jA 150 5,10399
1m6w9 150 5,94885
1mKNG 150 5,94885
1mgyA 150 5,73076
1molc 154 5,21398
1nQNU 151 5,96800
1o46v 150 5,73076
2lThd 148 5,55035
2ycR 150 6,56896
2znP 151 6,50371
3GOLv 151 5,72371
3jRv0 132 6,57084
3jXK8 154 5,53205
3k061 151 5,72371
3kgCH 152 5,34795
3mj9M 151 6,94336
3osgM 154 5,20039
3rdC1 150 5,74480
3sYVN 154 5,32879
3sYpi 151 7,63140
3tdgD 150 5,54955
3tpHm 150 5,09240
3vIzT 150 5,22569
3xnBC 150 6,41248
4Ld7a 149 9,05041
4VUO2 150 5,54444
4e2kq 208 4,84026
5KeNF 151 5,73008
5LOaZ 151 5,06631
5MQjd 150 5,34641
5NK4d 150 5,53205
5OXBt 150 5,36915
5PtvV 150 5,13207
5QVDa 145 6,28966
5RAIK 154 5,35636
5RND0 139 5,94106
5SnbW 151 5,53120
5Y9hJ 150 5,22569
5YLbR 154 5,51437
5ui7o 213 10,17938
614su 150 5,50022
61LMy 149 5,28690
62LgP 152 5,35903
65B02 154 5,53807
65NPx 139 5,50937
66cqj 139 5,94106
677wP 150 5,53807
67F9k 150 5,22830
68qab 150 5,34641
69QYI 150 5,36943
6FdwT 157 7,76815
6a8Fs 150 5,54631
6cWgU 152 6,30773
6iXRW 151 5,73013
6jGhs 154 5,09479
6kiEB 150 5,38563
6mW1u 154 5,70626
6mWvt 150 5,22421
6oZj7 150 5,04403
6okhk 152 5,53813
6pikL 150 5,34016
6thc0 151 5,72371
6uMbN 150 5,21386
6vE8B 150 6,11675
6wbL8 205 4,97747
704JZ 150 5,22569
70oq2 154 5,53807
73p3W 151 5,73013
74Js 226 9,48731
7xTn4 225 9,68936
7xz6V 223 9,36392
81oNx 148 5,30174
85y1f 148 5,52756
86rOF 150 5,09143
8f85W 151 5,73013
8faXE 150 6,44386
8idtV 154 5,23455
8kYDn 151 5,72996
8lhHY 145 5,91355
8owgC 150 5,63356
8qSvV 154 5,53807
8qqvU 205 10,37304
8rJVb 150 5,17345
OdKT 154 5,53205
oJHO 154 5,21398
oUu4 150 5,05665
rmFI 150 5,36142
F1ADS8 185 8,71717
A0A9E7QMF8 145 9,59878
A0A9E7MUM9 249 8,52016
A0AAN0KED3 186 9,18031
A0AAN0MNE7 186 9,18031
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_4532
3QBcV
 9 52,8% 157 1.680E-54
2 phalp2_8851
2IyxA
 73 46,8% 158 1.436E-44
3 phalp2_34935
4zXUV
 2 36,5% 175 1.242E-40
4 phalp2_11300
6W5mc
 5 40,8% 159 5.916E-40
5 phalp2_8397
FRHW
 6 30,4% 197 2.538E-33
6 phalp2_12598
1pcr7
 1 33,5% 155 1.969E-31
7 phalp2_7698
6IgBf
 1 34,0% 197 9.300E-31
8 phalp2_1418
1rFir
 138 34,5% 159 3.218E-30
9 phalp2_22537
1ofMS
 1 33,1% 175 6.248E-28
10 phalp2_6336
7d2ff
 6 30,3% 155 4.851E-24

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): 4CbTI (244 AA)
Member sequence: A0A2H5BQB7 (145 AA)
1 244 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudomonas phage TC6
[NCBI] 		2060947 Zobellviridae > Paundecimvirus > Paundecimvirus PA11
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG676466 [NCBI]
CDS location
range 20131 -> 20568
strand +
CDS
GTGCGAACGAATAATATCGACGCCATTAAAGAACACGAGGGGCTACGTCTTGTAGCCTACCTCGATTCTGTAGGGGTGTGGACTATTGGATATGGTGATACTGGCCCTGATGTAGTTAAGGGCCTTACTATCACTAAGGAAGAGGCCGAGAAGCGTCTTAGGAAGCGTCTGGTGGAGTTTGAAGGGTATGTCAATACCTACGTCAAGGTTCCACTAAAACAGCATCAGTTCGACGCTCTGGTGAGTTTGGTGTACAACATTGGTCCTGCTAACTTCAAGACCTCGACGTTGCTTAAGAAGCTTAATGCTGGGGATTATATTGGAGCGGCTGATCAGTTCCTAGTGTGGGACAAAGGCCGAGTAGATGGGAAGCTTGTTGTGATTAAGGGTCTTGCTAATAGGCGGGCCAAAGAACGTAAACAATTCCTTGGAGAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi000ca1ded7_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (4CbTI) rather than this protein.
PDB ID
4CbTI
Method AlphaFoldv2
Resolution 92.06
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50