Protein

Protein accession
A0A068Q6I2 [UniProt]
Representative
2STUM
Source
UniProt (cluster: phalp2_20366)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MADLRQRIVAGALAASAAGLTFIATHEGTVQQSYADPALGWKVPTICTGHTGPDVYRGQVATKEMCRAWLQQDSASAAKAVHRCVSYRLNQPQFDALVSFTFNVGQTAMCSSTLVRKLNAGDLQGASAEFPRWNRSGGKVLPGLTNRRAAERKLFDTGAYE
Physico‐chemical
properties
protein length:161 AA
molecular weight:17348,5 Da
isoelectric point:9,42
hydropathy:-0,22
Representative Protein Details
Accession
2STUM
Protein name
2STUM
Sequence length
308 AA
Molecular weight
33790,45460 Da
Isoelectric point
9,98307
Sequence
MRYAVIDGCPCPRPLYPILRKLKAETGCTYNSIYRGDDVAGILHQFGKHTQRELFEELPPGVANPPDRGTHILLGDGVVGALHEKLPWWKCGIDINDSQVDAVIAAAAKHGWKLYRPYPTGSEYHHVNFASKPSRWKALYRAVFGSKKPKRKRRPTPRPPRPTKLSKKGAEFIARFEGFIAKPYQDAVGVWTIGFGHTSGVGPHSKRITKAQGLALLQADAAVAARAVRDLVDVRLNQKQFDALVSFTFNLGGGALAESTLLKKLNKGDYRGAQAEFGKWVHAGGQVLPGLVTRRAAEARLFAGGSYS
Other Proteins in cluster: phalp2_20366
Total (incl. this protein): 8 Avg length: 275,1 Avg pI: 9,53
Protein ID Length (AA) pI
2STUM 308 9,98307
2kJPh 327 9,31093
38QAY 316 9,70954
6E4bc 310 9,49917
6H9jc 310 9,48344
6RKKj 308 9,57041
A0A077KYL8 161 9,26374
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_38531
1FT5s
 3 34,3% 259 4.803E-27
2 phalp2_29467
1ADQo
 2 29,3% 228 9.463E-24

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): 2STUM (308 AA)
Member sequence: A0A068Q6I2 (161 AA)
1 308 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Ralstonia phage RSJ2
[NCBI] 		1481785 Autographiviridae > Risjevirus > Risjevirus RSJ2
Host Ralstonia solanacearum
[NCBI] 		305 Proteobacteria > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Ralstonia >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AB920995 [NCBI]
CDS location
range 43045 -> 43530
strand +
CDS
ATGGCTGACCTCCGCCAACGGATCGTGGCGGGTGCCCTCGCTGCTTCGGCGGCGGGGCTCACCTTCATCGCCACACATGAGGGCACCGTACAACAGTCCTACGCCGACCCGGCGCTCGGCTGGAAGGTGCCTACCATCTGCACAGGCCACACTGGCCCGGACGTGTACCGGGGCCAAGTCGCCACCAAGGAAATGTGCCGCGCGTGGCTACAGCAAGACTCCGCTTCTGCGGCCAAGGCTGTGCACCGCTGCGTATCCTACCGCCTCAACCAGCCGCAGTTCGACGCTCTGGTTAGCTTCACGTTCAACGTGGGGCAGACCGCCATGTGCTCATCGACGCTGGTGCGCAAGCTCAACGCTGGCGACCTCCAAGGTGCCTCGGCCGAGTTCCCTCGCTGGAACAGATCAGGTGGCAAGGTGCTACCGGGCCTGACCAACCGGCGCGCTGCCGAGCGCAAGCTCTTTGACACGGGAGCATACGAATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2STUM) rather than this protein.
PDB ID
2STUM
Method AlphaFoldv2
Resolution 93.02
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50