Protein

Protein accession
A0A1Q1PW74 [UniProt]
Representative
1uDRT
Source
UniProt (cluster: phalp2_16834)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MNKTKLAEQLKKHEGLKLKPYTDTVGKLTLGVGRNLIDKGITEQEALFMLNNDVDYFYRKLSKKLTWFKTLDDARQNVLVNMAFNLGIAGLMSFKKMLLACEHGNFKIAATEMLNSKWAKQVGNRAVELSEQMRTGEF
Physico‐chemical
properties
protein length:138 AA
molecular weight:15733,2 Da
isoelectric point:9,55
hydropathy:-0,35
Representative Protein Details
Accession
1uDRT
Protein name
1uDRT
Sequence length
202 AA
Molecular weight
22783,34960 Da
Isoelectric point
10,03987
Sequence
MLRFLKSLTFWTASSPKKKPIGFDRNIPSTPSIPKTSAPQPRPSVDQSAIHRPIIETRKKQRAAMIHQLTLHEGMRLAPYKCTSGKLTIGIGRNLDDRGITEEEAAYLLGNDIDDFQDRLAREIPWMVELDAVRQRVLLDMAFNLGVPGLLKFKRTLAAIKGKEYDRAAAMMLDSRWATQVGQRAKRLSHMMATGHIPPELI
Other Proteins in cluster: phalp2_16834
Total (incl. this protein): 24 Avg length: 165,8 Avg pI: 8,93
Protein ID Length (AA) pI
1uDRT 202 10,03987
1SKcq 198 9,94426
1Vj0u 204 10,29710
2U1XY 198 9,74422
4x1WJ 208 9,03404
59Tfi 147 9,72236
6X27v 208 9,43948
6X28M 202 9,93633
7oOK5 199 9,99223
eZ8M 201 9,53605
gWFT 198 9,84601
gvt3 142 6,30369
A0A1J0GVQ7 138 9,18586
A0A223LHH7 138 8,98949
A0A0H4A794 139 7,83660
A0A2S1GN54 139 9,62044
A0A649V1T6 139 9,24569
A0A6G6XVD6 138 7,92370
A0A6J5L714 149 5,31265
A0A6J5MNH2 138 8,04999
A0A6J5QZN9 134 6,33263
A0AA51R3V3 138 9,16213
A0AAX4G6X5 144 9,21010
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32797
2yPO8
 5731 62,5% 139 4.833E-66
2 phalp2_17008
8jNgs
 3526 58,3% 137 1.454E-57
3 phalp2_9780
80F6A
 154 57,1% 133 5.749E-55
4 phalp2_6283
6Psj3
 6 57,3% 129 2.509E-53
5 phalp2_27968
RI1z
 5083 53,3% 133 6.583E-47
6 phalp2_6928
2KMCh
 358 47,5% 160 3.169E-46
7 phalp2_24213
2KXlJ
 83 48,9% 147 1.525E-45
8 phalp2_22190
6RxcX
 29 47,9% 144 2.088E-45
9 phalp2_14448
4FjnP
 18 47,5% 143 4.834E-44
10 phalp2_18518
6Rxhb
 4 46,7% 139 1.241E-40

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 1uDRT (202 AA)
Member sequence: A0A1Q1PW74 (138 AA)
1 202 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pseudoalteromonas phage PHS21
[NCBI] 		1955235 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KY379511 [NCBI]
CDS location
range 28796 -> 29212
strand +
CDS
ATGAATAAAACAAAATTAGCTGAGCAACTTAAAAAGCATGAAGGCTTAAAGCTCAAGCCCTATACCGATACGGTAGGGAAATTAACGCTTGGTGTTGGCAGGAATTTAATAGATAAAGGCATCACAGAGCAAGAGGCGCTGTTTATGCTTAACAATGATGTAGATTACTTCTACAGGAAACTGAGTAAAAAACTAACTTGGTTTAAAACTCTTGATGACGCAAGGCAAAATGTACTTGTAAATATGGCGTTTAATCTCGGTATTGCAGGCCTTATGTCATTTAAAAAAATGCTATTAGCTTGCGAGCATGGCAACTTTAAAATAGCTGCTACTGAAATGCTAAATAGTAAATGGGCTAAGCAGGTAGGCAATAGAGCTGTTGAATTGTCAGAGCAAATGCGCACCGGTGAATTTTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1uDRT) rather than this protein.
PDB ID
1uDRT
Method AlphaFoldv2
Resolution 85.28
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50