Protein

Protein accession
A0A2S1GTB3 [UniProt]
Representative
8yxE3
Source
UniProt (cluster: phalp2_12381)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MAKVQFKQRTETTLLIVHCSATKPSMNWGLREIRQSHKERGFLDVGYHFIIRRDGTVEDGREVSAIGAHCEGKNYTSVGVCLVGGVNDKMQPEANFTPQQMESLKTLLAGLKREYPQASIHGHHDFAAKACPSFDVQRWLKSGELVTSDHG
Physico‐chemical
properties
protein length:151 AA
molecular weight:16853,0 Da
isoelectric point:8,38
hydropathy:-0,48
Representative Protein Details
Accession
8yxE3
Protein name
8yxE3
Sequence length
213 AA
Molecular weight
23680,55440 Da
Isoelectric point
7,65623
Sequence
mtrekttyiiwhcsatkpdmligasdidlwhkargfrgvgynrvirrdgtveqgrkdgeqgahckgynaqshgvcivgglgddgqpelnftdeqyvairkeaarlsvlypdathvghrdlaatlcpgfdisvylekrttgskqvildaleacelvsskwaedkgiskwnfvnlistmrkegtqissirrglsesiyfmeakasefitayvank
Other Proteins in cluster: phalp2_12381
Total (incl. this protein): 11 Avg length: 171,5 Avg pI: 8,51
Protein ID Length (AA) pI
8yxE3 213 7,65623
8AQgL 213 7,69523
8Fasi 213 8,29387
8wEXm 198 6,40487
A0A1P8L672 149 9,48164
A0A218M4E4 150 9,13325
A0A5Q2F6U8 149 9,45379
A0A5Q2U7Y4 149 9,45379
A0A7G8ZYQ0 150 8,95828
A0AA47LX30 151 8,72053
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_11894
2jrH4
 329 53,2% 139 1.684E-57
2 phalp2_28564
7Z48s
 97 46,5% 129 1.243E-54
3 phalp2_3887
6RreM
 7260 50,7% 134 1.901E-52
4 phalp2_24237
2YSsA
 71 41,0% 146 2.603E-52
5 phalp2_5171
285Oe
 13 48,1% 133 5.441E-50
6 phalp2_33574
8Fk8i
 28 39,5% 149 4.913E-46
7 phalp2_36193
72BPm
 409 51,1% 133 6.725E-46
8 phalp2_2237
4n15b
 512 46,2% 145 2.889E-41
9 phalp2_12261
71VXz
 7 40,1% 152 1.701E-39
10 phalp2_23565
7vNZv
 154 38,7% 142 4.670E-34

Domains

Domains [InterPro]
Ami2
Representative sequence (used for alignment): 8yxE3 (213 AA)
Member sequence: A0A2S1GTB3 (151 AA)
1 213 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Dickeya phage Ninurta
[NCBI] 		2163631 Autographiviridae > Ningirsuvirus > Ningirsuvirus ninurta
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH059639 [NCBI]
CDS location
range 10379 -> 10834
strand +
CDS
ATGGCTAAAGTACAATTCAAACAGCGCACTGAGACAACCCTGCTCATCGTTCACTGCTCGGCTACCAAGCCCTCAATGAATTGGGGTCTTCGTGAAATCCGTCAGTCTCATAAGGAACGCGGGTTCCTCGACGTAGGGTATCACTTCATCATTCGCCGCGATGGTACTGTTGAAGATGGTCGTGAAGTGTCCGCTATCGGTGCTCACTGCGAAGGAAAAAACTACACCTCTGTGGGTGTCTGTCTGGTCGGTGGTGTCAATGATAAGATGCAGCCTGAAGCGAACTTTACGCCACAACAGATGGAGTCCCTGAAGACCCTACTGGCTGGCCTGAAGCGCGAGTATCCGCAAGCGTCGATTCATGGTCATCATGACTTCGCTGCGAAAGCCTGTCCGTCCTTTGACGTGCAGCGTTGGTTAAAGTCTGGTGAACTCGTTACGAGTGACCACGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0032897 negative regulation of viral transcription biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04111

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8yxE3) rather than this protein.
PDB ID
8yxE3
Method AlphaFoldv2
Resolution 78.43
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50