Protein

Protein accession
A0A2K9V2U2 [UniProt]
Representative
38IkX
Source
UniProt (cluster: phalp2_10709)
Protein name
Endolysin, N-acetylmuramoyl-L-alanine amidase domain
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSLTGKNNEEKIWNFLTGKGLNSYGAAGLMGNLFAESGLNPHNLQNTYEKKLGYTDNSYTEAVDSGKYTGFTHDSAGYGLAQWTYWSRKEALLNYVKAAGASIGDLETQLGFLWKELGENYAAVLATLKKATSVRQASDAVLLKYEQPKDQSASVQTKRASYGQTYFDKYATKTTNDTQGGKTMSNSPLVDCTVYSPNHSGKRTHSIDRLTPHCVVGQLSAETIGACFPKGRDASCNYGIGYDGRVCLIVDECNRSWCSSSNANDQRAITIECASDKSEPYAMKSAVYEKLIKLCADICKRNGKTKVLWLGSKEKALTYEPKANEIVLTAHRWFANKSCPGDWLYSRYGELADRINALLGSTDSGSSGGSSTPSGGSGVKYYVQTGAYKQKANADTQLKKVKAAGFDAILKQSGGFYKVQTGAYSKKENADAEVKKLKAKGFDAIVTTDGGSTAGSTNSEIKVGDVVQFSGGSHYGSAAASTAAGTPKAGPAKVTRIVKGAKHPYHIVHTDSQSNVYGWVDAANVSK
Physico‐chemical
properties
protein length:527 AA
molecular weight:56597,6 Da
isoelectric point:9,06
hydropathy:-0,51
Representative Protein Details
Accession
38IkX
Protein name
38IkX
Sequence length
309 AA
Molecular weight
34071,10320 Da
Isoelectric point
6,91483
Sequence
MGYSNSGLVDVVYKSPNHSGQRTHKIVYITPHCVVGQLTASGIGACFPAGRDASCNYGIGRDGKVVLVVDEKNRSWCTSSGFNDQRAVTIECASDAYHPYAFNSAVWNKLVLLCADICKRNGIKKLLWLGSANKTWNYNIKDGEACLTAHRWYDSKSCPGDWCYSRLGTLASEVNKRLGSGSSSAPIVAPSSKIEEDGIWGCDTTYLSQKVMKTYEDGIVSDQNSDCRVYLPACIDDSWEFVYYPEDGSVLVEAIQKMVGAEVDGIAGYETVTKLQKWLNRTRSAKLDEDGILGEKTCKAWQKYLNSKV
Other Proteins in cluster: phalp2_10709
Total (incl. this protein): 3 Avg length: 382,7 Avg pI: 7,29
Protein ID Length (AA) pI
38IkX 309 6,91483
235zk 312 5,88189
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_8931
3gTAK
 6 50,2% 219 1.477E-70
2 phalp2_2329
4MdvC
 2 36,2% 328 2.764E-70
3 phalp2_26095
7w4x3
 24 50,9% 210 1.322E-69
4 phalp2_36687
5KtCw
 1 42,0% 321 1.809E-69
5 phalp2_29674
8k36v
 96 40,7% 314 5.060E-67
6 phalp2_12971
3esnk
 626 45,7% 221 8.924E-61
7 phalp2_24261
38Fx8
 4 52,8% 195 2.278E-60
8 phalp2_5505
3kRYJ
 67 46,0% 202 2.094E-54
9 phalp2_5205
41m1U
 3 43,3% 203 2.828E-44
10 phalp2_24438
4y2d5
 7 44,7% 201 1.591E-42

Domains

Domains [InterPro]
Ami2
Unannotated
Representative sequence (used for alignment): 38IkX (309 AA)
Member sequence: A0A2K9V2U2 (527 AA)
1 309 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Faecalibacterium phage FP_Lagaffe
[NCBI] 		2070183 Lagaffevirus > Lagaffevirus lagaffe
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG711461 [NCBI]
CDS location
range 25313 -> 26896
strand +
CDS
ATGTCACTCACAGGAAAAAACAACGAGGAAAAGATCTGGAATTTTCTCACCGGCAAGGGCCTGAACTCATACGGAGCCGCCGGGCTTATGGGGAACCTGTTCGCAGAGAGCGGGCTCAACCCTCACAACCTCCAGAACACCTACGAGAAAAAGCTCGGCTATACAGACAACAGCTACACCGAAGCGGTGGACTCCGGAAAGTATACCGGCTTCACGCATGACTCCGCAGGCTACGGCCTCGCCCAGTGGACATACTGGAGCCGCAAGGAGGCGCTCCTGAATTATGTCAAGGCTGCCGGTGCCTCGATTGGAGATCTGGAGACTCAGCTCGGCTTCCTCTGGAAAGAGCTCGGCGAAAACTACGCCGCAGTGCTGGCCACGCTGAAAAAGGCAACCAGTGTGAGACAGGCTTCCGACGCCGTACTGCTCAAATATGAACAGCCAAAGGATCAGAGCGCAAGCGTCCAGACGAAACGGGCCAGCTACGGGCAGACCTACTTCGACAAATACGCAACCAAGACAACCAACGACACACAAGGAGGTAAAACCATGAGCAATAGCCCATTAGTGGACTGCACAGTTTACAGCCCTAACCACAGCGGAAAAAGAACCCATTCGATCGACCGCCTGACTCCGCACTGCGTAGTCGGCCAGTTATCCGCCGAAACGATCGGCGCCTGCTTCCCTAAAGGCAGGGACGCAAGCTGCAACTACGGGATCGGGTACGACGGCCGCGTCTGCCTGATCGTGGACGAGTGCAACCGTAGCTGGTGCAGCTCCAGCAACGCAAACGACCAGAGAGCGATCACGATCGAGTGCGCCAGTGATAAGTCCGAACCATACGCCATGAAGTCCGCAGTTTATGAGAAACTGATCAAGCTCTGCGCTGACATCTGCAAGAGAAACGGAAAAACGAAGGTGCTCTGGCTCGGCAGCAAGGAGAAAGCTCTCACATACGAGCCGAAGGCGAACGAGATCGTCCTCACCGCACACCGCTGGTTTGCGAATAAATCGTGCCCCGGCGACTGGCTTTATTCCAGATACGGAGAGCTCGCCGACAGAATCAATGCGCTGCTCGGCTCTACTGACTCCGGCAGCTCCGGTGGAAGTTCTACGCCTTCCGGCGGCTCTGGCGTGAAATACTACGTCCAGACGGGAGCCTATAAGCAGAAGGCAAACGCCGACACTCAGCTCAAAAAGGTGAAAGCTGCCGGTTTTGACGCCATTCTCAAACAGTCCGGCGGCTTCTACAAGGTGCAGACCGGCGCCTACTCCAAGAAAGAAAACGCCGACGCCGAAGTCAAAAAGCTGAAAGCGAAGGGCTTCGACGCAATCGTGACGACCGACGGCGGAAGCACTGCCGGATCCACGAACTCTGAGATCAAAGTCGGCGACGTGGTTCAGTTCTCTGGCGGCTCTCACTACGGAAGCGCTGCAGCTTCGACTGCTGCCGGAACTCCGAAAGCTGGCCCGGCCAAAGTCACCAGAATTGTGAAGGGCGCAAAGCACCCGTACCATATCGTACACACTGACAGCCAGTCCAATGTCTACGGCTGGGTGGACGCGGCCAACGTCTCGAAATGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0042834 peptidoglycan binding molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0001b2faa3_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (38IkX) rather than this protein.
PDB ID
38IkX
Method AlphaFoldv2
Resolution 91.63
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50