Protein

Protein accession
M4Q818 [UniProt]
Representative
7v6GH
Source
UniProt (cluster: phalp2_36893)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
LVQIGGYYEGEFTPQSTYATQVASTIAQGKRAHTYIFADFSSNTEADSMLNYYLPKVQTPKGSIVALDVEEGNPNTASVEYALAKIKVAGYTPVLYGYKSFLTAHLDLASIAKTYPLWLAEYPNYDVTTSPNYNYFPSYDNIGIFQFTSTYKAGGLDGDVDLTGITDDGYTGTTTSSTGKTTVSTTTTTAAVSAGQTANDTSKSSIAAGYTVKVNFSASKWSTGESIPSWVKGQSYKVSQVSGNNVLLAGIDSWISKSNVEILLTASTTAK
Physico‐chemical
properties
protein length:271 AA
molecular weight:28915,6 Da
isoelectric point:5,02
hydropathy:-0,20
Representative Protein Details
Accession
7v6GH
Protein name
7v6GH
Sequence length
167 AA
Molecular weight
18021,99340 Da
Isoelectric point
5,75133
Sequence
LTHKKLNTILITISALSAFAITSPVFAAKGDQGVDLSHYQTSTAEFGQASDKFALVQIGGYYEGEFTPQSTYATQVASTIAQGKRAHTYIFADFSSNTEADSMLNYYLPKVQTPKGSIVALDVEEGNPNTASVEYALAKIKVAGYTPVLYGYKSFLTSLESIHQSTI
Other Proteins in cluster: phalp2_36893
Total (incl. this protein): 34 Avg length: 259,1 Avg pI: 8,55
Protein ID Length (AA) pI
7v6GH 167 5,75133
1nRMX 129 9,27244
3lKmF 160 9,02488
3ufjR 164 9,42549
3wrr6 189 7,74735
5V420 135 9,07168
5Yt9p 131 9,45411
60RES 159 9,49241
60ifi 140 8,75250
60ylB 130 9,07188
6dgq4 141 8,80711
6hbuH 189 8,87016
6lXNC 101 9,39783
77tCs 186 9,28366
7RoCI 174 9,32440
7mvEE 221 8,82709
7wIVd 134 5,04301
7wYeC 176 9,31828
7wziB 103 9,39783
7xb0C 149 5,51090
A5A5E0 418 8,92192
Q9ZXB4 432 9,26793
E9LUK3 415 9,03661
V5UQT2 431 9,36817
V5UTJ0 430 8,95977
A0A0A7NU10 489 8,91322
A0A2U9PEI5 432 9,03874
A0A6M3BDU4 418 8,93127
M4PWU0 271 5,01976
Q6A204 432 9,31737
Q6EVN0 432 9,40615
Q9ZXH8 432 9,40615
V9QIZ5 430 9,16317
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_12156
6iQWP
 264 41,7% 158 1.061E-40
2 phalp2_9068
5tY7Z
 4 49,1% 118 4.731E-36
3 phalp2_10061
7upZQ
 3 26,1% 134 7.355E-06

Domains

Domains [InterPro]
Disordered region
GH25
Representative sequence (used for alignment): 7v6GH (167 AA)
Member sequence: M4Q818 (271 AA)
1 167 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Oenococcus phage EGM-2013
[NCBI] 		1303346 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KC292247 [NCBI]
CDS location
range 1 -> >813
strand +
CDS
CTTGTTCAGATCGGTGGTTATTACGAAGGTGAATTTACTCCGCAATCCACTTATGCTACGCAAGTTGCAAGTACGATTGCCCAGGGCAAACGGGCACACACCTATATCTTTGCCGACTTTTCTTCTAATACCGAAGCTGATAGCATGCTTAACTACTACTTGCCAAAAGTCCAAACACCTAAAGGCTCAATCGTGGCCTTGGATGTTGAAGAGGGCAATCCAAACACTGCAAGTGTTGAATATGCCCTGGCTAAAATTAAAGTCGCTGGTTACACACCAGTTCTTTATGGCTATAAGTCATTTCTAACTGCTCATTTGGATCTAGCTTCAATCGCCAAGACTTATCCCTTGTGGCTAGCTGAATACCCTAACTACGATGTCACCACTAGTCCCAACTATAACTATTTCCCTAGTTATGACAATATTGGTATCTTTCAATTCACATCGACCTATAAGGCTGGTGGTTTAGACGGTGATGTTGATTTAACAGGGATTACCGATGACGGTTATACAGGTACTACTACTTCATCTACTGGTAAGACGACCGTTTCGACAACGACCACGACAGCTGCTGTTTCAGCTGGTCAGACAGCCAACGATACTTCTAAATCAAGTATTGCCGCTGGCTATACGGTTAAGGTCAATTTTTCGGCTTCTAAATGGTCGACTGGTGAATCGATTCCAAGCTGGGTGAAAGGACAAAGCTATAAAGTTAGCCAGGTATCAGGCAATAACGTTCTCTTGGCTGGAATCGATTCGTGGATTAGTAAGAGCAATGTTGAAATTCTATTAACCGCTTCAACGACTGCTAAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0002c05eed_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7v6GH) rather than this protein.
PDB ID
7v6GH
Method AlphaFoldv2
Resolution 82.05
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50