Protein

Protein accession
A0A4D6A7S0 [UniProt]
Representative
725t1
Source
UniProt (cluster: phalp2_24803)
Protein name
Cell wall hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGKHLVICGHGQGQSSYDPGATNSSLGITEAGKVREFANLMKKYSGNQIDYITDQNVYDYRSIGSLGNGYESITELHFNAFNGQARGSEILIYAGYSADSLDQKLLAILAKRFTNRGFKQVNWLYNANVSASRGYNYRLVEIAFIDNNSDVGIYEANKDSMAREFVQAITGQAQVISPSPNTPQSRVTSYHVGDSVTVQQHATHYQTGQAISSWVKGKTFKVIRVKDVNQSNSKKAYLLEGINSWVLEQDVKGTTNGHSEQTYTVQKGDTLYGIARKFKTSVSELVRLNSIINPSLISVGQKLKLK
Physico‐chemical
properties
protein length:306 AA
molecular weight:33815,5 Da
isoelectric point:9,30
hydropathy:-0,44
Representative Protein Details
Accession
725t1
Protein name
725t1
Sequence length
470 AA
Molecular weight
52384,51770 Da
Isoelectric point
9,16142
Sequence
VTFLERIKEGCLAGWQHGILPSVSAAQAVLESGWGQSALAQSPNHNLFGIKASGDWTGKVVRLPTQEFRQGKMGIEVASFRKYDSWEASIIDHAVFFSSTDWRRRNYAAVIGEKSYRKACLALQAAGYATDPNYAVKLIALIQEHQLYEWDKSLQQETVKGEQKMGKHLVICGHGKGPSGYDPGAVNRSLGITEADKVREFAQLMAVYSGNQIDYITDQNVYDYRSLGSIGKGYDSITELHFNAFNGQARGTEILIYAGYQPDSLDQKLLAALSSRFTNRGIKKVEWLYNANVAASKGYNYRLVEIAFIDNHADMAIYEAHKRVLAKEFVQAITGQVSAFPSTASSASQSSFRYHLGDSVRVEKHATHYQTGHPIKSFVKGKSYRIIRVKEVNQSNSKYAYLLEGINSWVLEQDLAPSTLGHSEQTYTVQKGDTLSSIAKRFKTTYQELARINSIPDPNRIKVGQVLKLV
Other Proteins in cluster: phalp2_24803
Total (incl. this protein): 19 Avg length: 385,5 Avg pI: 8,37
Protein ID Length (AA) pI
725t1 470 9,16142
13cOt 576 8,57973
2m3 468 8,73355
2sL 468 8,84430
71X0X 420 7,66692
7AX5W 336 7,71239
7Rkr9 386 8,84095
7hEQV 468 8,57367
7hIBg 466 8,84437
7iPF8 466 8,84437
7qnd5 468 9,23453
7tcZl 564 8,94655
A0A4D6BGQ7 386 8,84095
A0A4D6B6P1 107 6,89903
A0A4D6A666 145 5,69216
A0A4D6B455 359 8,70428
A0A4D6B7G6 359 8,70428
A0A4D6B2Q1 107 6,89903
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_26068
7j23J
 9 74,7% 305 2.056E-153
2 phalp2_23517
71Vqv
 51 61,3% 313 3.973E-116
3 phalp2_37594
45uQn
 106 34,9% 363 8.005E-57
4 phalp2_429
7BmmE
 20 30,2% 413 3.222E-48
5 phalp2_31497
3TCAn
 6 25,2% 459 1.084E-47
6 phalp2_14098
7ooYL
 2 27,6% 441 1.987E-47
7 phalp2_2700
7bONi
 21 30,1% 362 3.885E-41
8 phalp2_37214
234pK
 1 30,0% 333 3.609E-35
9 phalp2_32385
yZyv
 16 33,3% 321 4.627E-31
10 phalp2_9614
1Eh3E
 1 25,5% 528 1.568E-29

Domains

Domains [InterPro]
GLUCO
Ami3
Unannotated
LysM
Representative sequence (used for alignment): 725t1 (470 AA)
Member sequence: A0A4D6A7S0 (306 AA)
1 470 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF01520, PF01832

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan29
[NCBI] 		2548095 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448726 [NCBI]
CDS location
range 33625 -> 34545
strand +
CDS
ATGGGAAAACATTTAGTTATCTGTGGACACGGTCAAGGTCAATCAAGCTATGATCCTGGAGCAACTAACTCTAGTTTGGGAATTACAGAAGCAGGAAAGGTTCGTGAGTTTGCGAATCTGATGAAGAAGTATTCTGGGAATCAGATTGATTATATCACTGACCAGAATGTCTATGACTATCGCAGTATTGGTAGTTTGGGAAATGGCTATGAGTCGATTACAGAACTTCATTTTAACGCCTTTAATGGTCAGGCTCGAGGGAGTGAAATTTTGATTTATGCAGGCTATTCAGCTGATAGTTTAGACCAAAAACTGCTGGCTATTCTTGCCAAGCGTTTTACGAATCGTGGTTTTAAACAAGTGAACTGGCTCTACAATGCCAATGTCTCAGCAAGTCGAGGCTACAATTATCGATTGGTGGAGATTGCCTTCATCGATAATAATAGTGATGTGGGCATCTATGAAGCCAATAAAGACAGTATGGCTCGTGAATTTGTACAAGCCATCACTGGGCAAGCTCAAGTAATTTCACCCAGTCCCAATACTCCTCAATCAAGGGTTACTTCCTATCATGTTGGTGACTCTGTTACTGTTCAACAACATGCGACGCATTACCAGACAGGTCAAGCGATTTCGTCATGGGTTAAAGGCAAAACTTTCAAGGTTATTCGTGTGAAGGATGTTAATCAATCCAATAGTAAGAAAGCCTACCTGCTTGAGGGAATTAACTCATGGGTCTTGGAACAAGATGTCAAAGGCACAACGAACGGACATAGTGAACAGACTTATACGGTACAAAAGGGAGATACTCTTTATGGCATTGCACGGAAGTTTAAGACCAGTGTCAGTGAATTGGTGCGACTTAACAGCATCATCAATCCAAGTCTGATCTCAGTTGGACAGAAGTTGAAACTAAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0002bc1594_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (725t1) rather than this protein.
PDB ID
725t1
Method AlphaFoldv2
Resolution 87.84
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50