Protein

Protein accession
A0A0A7DMK9 [UniProt]
Representative
7iNag
Source
UniProt (cluster: phalp2_387)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKKKIIPILLSSATVLGLMFANKISAATREEGVDVSSYQGSSSSYFKTLKNKGAKFVIVKVGGSGGGEGYHYQNPSASMQLANAKVNGLAVGAYFWAECGSSSSEALRMAKLAVSDAKRAGLKTSSVIAMDYEAGAYASQKTANTNAVITFMDHIKKAGYKPLFYSGASFARSNVDTKKLVNKYGKSALWIASYKTMNAQYTPDYNYFPSMDGIGIWQYADNWKGLNVDGNVQFFKVISNGEVTKKTPVKQANATTNKENGVKKFPKDNTYTVKNGDSWSSIAKAYGIDVNGLAKLNGATTKTMLHPGQKLKLTGHVSNVATKKPKKTTTKKKTVKKHSWIKKSGYFRLNTTIKLRSGASTSSRVISTLYRGQVIKFDAYKISGGYVWLRQKRSNGYGSVASGVAKNGKRVSTWGTIF
Physico‐chemical
properties
protein length:418 AA
molecular weight:45389,5 Da
isoelectric point:10,09
hydropathy:-0,40
Representative Protein Details
Accession
7iNag
Protein name
7iNag
Sequence length
379 AA
Molecular weight
42119,05120 Da
Isoelectric point
9,89959
Sequence
MKLKKLLLTALLSSLIFLFPQKVDAARRLGIDVSSYQRSDYQFFQNMKANGTKFVIVKLGGSGGGEGEHYQNPKASQQLAMAQKVGLEVGSYFWGEFGGSVAQAKKMAKYAVSDAQKFGLKKGSAIALDYELGASQNKEENTKAIHEFMSYIKKQGYKPLLYSGSYYLKTNVNHSKVNKSFKNSLWIASYATMAPVNGPNYNYFPSLDGIAIWQFSSAWYGVDGNVELLKNSLKLGKVKDDVKVTKTKKSKATSYTVKAGDSWYSIAQKFGMDQNQLAKLNGGTVNSELQPGDKLKLTGTIKNDAKPTKVKTKIVKVKSLGKDRKNWKVRLIDGSGKYSNHYVNQGSRWITSKTKETKKGKAYLIGKNLYVLAKYVKIE
Other Proteins in cluster: phalp2_387
Total (incl. this protein): 20 Avg length: 405,6 Avg pI: 9,78
Protein ID Length (AA) pI
7iNag 379 9,89959
5oINm 429 9,56770
5tWLw 415 9,57796
60lKE 407 10,05264
6prOV 367 9,83280
71xhX 439 9,83299
73Scb 439 9,62089
75pzV 427 9,48435
7BVY3 397 9,85878
7fRlg 325 9,59678
7fkIW 413 9,51213
7iQNx 405 9,08890
7jz26 418 10,09041
8LL06 399 9,92196
8jFBT 403 9,86484
8jG9k 397 9,81868
i5b 418 10,02027
A9UJV4 399 9,92196
A0A3G6JGZ1 418 10,02027
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_1050
734XP
 69 46,7% 248 1.874E-74
2 phalp2_12156
6iQWP
 264 45,9% 246 7.982E-68
3 phalp2_21701
3ifCN
 920 31,1% 379 7.575E-47
4 phalp2_17635
6JmE3
 482 27,8% 398 2.912E-39
5 phalp2_362
76MmF
 5 29,2% 291 1.285E-28
6 phalp2_9283
7cTgF
 101 29,0% 299 2.065E-26
7 phalp2_39679
5kP
 52 27,5% 363 2.302E-19
8 phalp2_30714
7hCUl
 46 25,8% 399 1.323E-18
9 phalp2_17042
7nSW4
 41 27,3% 300 3.224E-17
10 phalp2_10110
c1k0
 16 21,8% 357 1.374E-14

Domains

Domains [InterPro]
Disordered region
GH25
LysM
Unannotated
Representative sequence (used for alignment): 7iNag (379 AA)
Member sequence: A0A0A7DMK9 (418 AA)
1 379 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage Ldl1
[NCBI] 		1552735 Lidleunavirus > Lidleunavirus Ldl1
Host Lactobacillus delbrueckii subsp. lactis
[NCBI] 		29397 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus > Lactobacillus delbrueckii

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KM514685 [NCBI]
CDS location
range 36477 -> 37733
strand +
CDS
GTGAAAAAGAAAATTATCCCAATATTGTTGTCCAGTGCTACTGTTTTAGGTTTAATGTTTGCTAACAAAATAAGCGCAGCTACTAGAGAAGAAGGTGTCGATGTATCAAGTTACCAAGGCTCATCTTCTTCCTACTTCAAAACTCTGAAGAACAAGGGTGCTAAATTTGTAATTGTAAAAGTTGGCGGCTCTGGTGGTGGAGAAGGTTATCACTACCAAAACCCTAGCGCTTCAATGCAATTGGCAAACGCAAAGGTAAACGGTTTGGCAGTTGGTGCATATTTCTGGGCAGAATGTGGTTCATCAAGTTCAGAAGCATTAAGAATGGCGAAGTTAGCCGTATCTGACGCTAAGAGAGCCGGTTTAAAAACTAGTTCTGTTATTGCAATGGACTATGAAGCTGGCGCTTACGCTTCACAAAAGACAGCTAACACCAACGCAGTAATCACGTTTATGGACCACATTAAGAAGGCTGGCTATAAGCCACTCTTCTATAGTGGCGCTTCATTTGCTAGATCTAACGTAGACACTAAAAAGTTGGTTAATAAATATGGTAAGAGTGCGCTCTGGATTGCTTCTTACAAGACTATGAACGCACAGTATACACCTGACTATAATTACTTCCCTTCAATGGACGGAATTGGTATTTGGCAATATGCGGACAACTGGAAGGGTTTGAATGTTGACGGTAACGTACAATTCTTCAAGGTAATTAGTAACGGTGAAGTTACCAAGAAAACTCCAGTTAAGCAAGCAAACGCTACTACTAATAAAGAAAACGGTGTAAAGAAGTTTCCAAAGGACAACACTTACACGGTTAAGAATGGCGACAGTTGGTCTTCTATTGCTAAGGCTTACGGTATTGACGTAAACGGTCTAGCAAAGCTCAATGGCGCTACCACTAAGACTATGTTGCATCCCGGACAAAAACTGAAGCTGACTGGGCACGTTTCAAACGTGGCTACTAAGAAACCTAAGAAGACTACTACCAAGAAAAAGACAGTAAAGAAGCACTCATGGATTAAGAAGAGTGGCTATTTCAGACTGAATACTACCATCAAGTTACGATCTGGAGCAAGCACATCTTCTAGAGTCATTTCTACTCTGTACAGAGGTCAAGTCATCAAGTTTGATGCTTATAAGATCTCTGGTGGTTATGTTTGGTTAAGACAGAAGAGAAGTAACGGATACGGCTCTGTTGCTTCTGGTGTTGCTAAGAACGGTAAGAGAGTATCAACTTGGGGCACGATTTTTTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (7iNag) rather than this protein.
PDB ID
7iNag
Method AlphaFoldv2
Resolution 85.59
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50