Protein

Protein accession
U3TK98 [UniProt]
Representative
1LaGk
Source
UniProt (cluster: phalp2_26423)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGTKLNAIKSGAIALTLSGLGLTGAFQLVDTFEGNKTSTYLDPLGIPTVCRGTTTGPLVGRKNVTAQECDEQTIKDIQVAAATVRSCVKVPLTLGEYSAWTSFAYNVGPGRKGVKDGMCVLKSGAVPSHLRLLNAGDSRGACKKLFDWTMPGTSVHRGLLARRTAEYSMCVRDLALKED
Physico‐chemical
properties
protein length:179 AA
molecular weight:18995,7 Da
isoelectric point:9,22
hydropathy:-0,06
Representative Protein Details
Accession
1LaGk
Protein name
1LaGk
Sequence length
259 AA
Molecular weight
26978,34750 Da
Isoelectric point
9,42620
Sequence
VSTGRVLVAALTLSAAGLIGIAVSEGWEPVARPPVPGDVPTGGFGSTRGESGPMRPGERIDPVRGLILLQRDASEAERIVRRCAPVPMHQREFDAFVSLAYNVGPGKAGVKDGFCELKRGGPSTIVRRLRAGDYKGACDAILSWDRFQGKPLRGADAAPPARARGLHHSGAAQTLNTWDAWCWAVSPTNAKLYRNGAQVYSGAHSGLANPAGVSFRCAVGNGLGAPGSNTGGIRAHIDELVIVKGWAGDISGITSEIVL
Other Proteins in cluster: phalp2_26423
Total (incl. this protein): 3 Avg length: 203,0 Avg pI: 9,31
Protein ID Length (AA) pI
1LaGk 259 9,42620
A0A1L7DS69 171 9,27624
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15849
4kKIv
 1444 47,8% 163 3.749E-30
2 phalp2_28113
7zmZV
 50 33,1% 166 2.006E-12

Domains

Domains [InterPro]
Unannotated
Disordered region
Representative sequence (used for alignment): 1LaGk (259 AA)
Member sequence: U3TK98 (179 AA)
1 259 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Ralstonia phage RSB3
[NCBI] 		1402875 Autographiviridae > Jiaoyazivirus > Jiaoyazivirus RSB3
Host Ralstonia solanacearum
[NCBI] 		305 Proteobacteria > Betaproteobacteria > Burkholderiales > Burkholderiaceae > Ralstonia >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AB854109 [NCBI]
CDS location
range 40999 -> 41538
strand +
CDS
ATGGGAACAAAGCTCAACGCGATTAAAAGCGGCGCTATCGCCCTCACCCTCTCGGGCTTGGGACTGACCGGCGCATTCCAGTTGGTCGATACGTTCGAGGGCAACAAGACCTCGACGTACCTCGACCCGCTGGGTATCCCGACTGTCTGCCGAGGGACCACGACCGGTCCCCTCGTCGGGCGCAAGAACGTCACGGCGCAGGAGTGTGACGAGCAGACTATCAAGGACATCCAAGTTGCTGCGGCGACCGTGCGCTCGTGCGTGAAGGTTCCGCTGACGCTTGGTGAGTACAGCGCGTGGACGAGCTTCGCCTACAACGTGGGGCCGGGTCGCAAGGGTGTGAAGGACGGGATGTGCGTGCTGAAGTCCGGCGCGGTGCCCTCCCACCTGCGGCTGCTCAACGCGGGTGACTCACGCGGCGCGTGCAAGAAGCTGTTCGACTGGACGATGCCGGGAACATCCGTGCATCGCGGGCTGCTCGCGCGCCGCACGGCGGAGTACTCGATGTGCGTGCGCGACCTCGCGCTCAAGGAGGACTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0003b093b8_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1LaGk) rather than this protein.
PDB ID
1LaGk
Method AlphaFoldv2
Resolution 61.74
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50