Protein

Protein accession
M4W627 [UniProt]
Representative
5hxHI
Source
UniProt (cluster: phalp2_30503)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MAFIQKQGYWISENGWRMCDTAELDYSAIPGTDFKLGVRKGAPSVILKALIWRLHRIEPMITTQIGCYTSSNSMANSNHNSATAIDYNWNLHPYQKWGTWGSKRPAVDQVIKDFRGIVEFGGDWTSPRDEMHFELHFAEGHAGTEQLATDLRNGLWGIYADGTAPPPVVIPEGYLQLGSEGDQVRKLQAGMNKVFRNYKAMPLDEDGIFGAFTESAVKEFQRRSLIGVDGIVGPETKQRLATYGIILDGATEPTSPPPPVVPSFVYPSTDEMVKQVWEQHFGPKAEGWPQLGQTPEGKNRYLVDGVASLIAKEEA
Physico‐chemical
properties
protein length:315 AA
molecular weight:35005,0 Da
isoelectric point:5,44
hydropathy:-0,42
Representative Protein Details
Accession
5hxHI
Protein name
5hxHI
Sequence length
559 AA
Molecular weight
61349,32280 Da
Isoelectric point
5,65351
Sequence
MSFRVVYGQSRSENGWRMCNADETDSLPIPGSSVRIPLRSGVPSTILRAFASRFNQLIEPLDQTQCGGWTPTNSVATSNHLAGSAVDLNWRLHPFRVKGTFGDKLPVLRNILREFEGTVFYGGDWANPIDEMHFQMNYDCFEGSKKAEDFAQRLLNGHLGIYASANPNDFPLPLGYYYGPLSGPNESVSGEWAGERPEWRAGLKRWQKALGLKQTGKWNDGVTAKAATTLQLAKRWPPHPDFGYGGVYLGEWDAVIKNGWRLPDGWKPDAVPATRVKWADVSQYQTATLDATYPYPVVAFRASVADRRDTKFLANMTAARKLVAAGKLQKVIAYHFWVPGYDNVGTFMSALESSGGIFPELAFMIDVEDGGTKWNITGDQSDGVNDFIDRVSERFGNPAAAVGYLNFRSNQDLWKTIPHGLKLIVPAYSGPESKPWVPEGYTAFGHQYADNEDTPPFGPCDINQAHMTLADFISAFGVQAVPDLVPDSGTTPVPPPTGAGSLTLTGRPLDPRIPDDLAGHVLSMRMEGLRTQALVAALCEANNIDVSDVFNKVKDAVTP
Other Proteins in cluster: phalp2_30503
Total (incl. this protein): 19 Avg length: 421,4 Avg pI: 5,43
Protein ID Length (AA) pI
5hxHI 559 5,65351
1IfsK 503 4,39169
1Ifvi 524 4,46461
416Bq 508 5,38648
5svdG 466 4,78007
7AJDF 530 4,91966
7BtFW 530 5,10706
A0A249XT09 530 4,91966
B3VM63 318 5,42974
B5U509 321 5,75361
B5LJL3 530 5,10706
A0A2P1K0B0 321 6,10715
S5YB17 315 5,56484
A0A3S9U8E5 253 7,74451
A0A514CWK8 321 6,01160
A0A7D5JSM2 321 6,10715
A0AAE7XGC8 527 4,86914
A0AAE9GCD4 315 5,43923
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_39755
8MRZu
 55 29,4% 502 1.790E-79
2 phalp2_36515
1p8L5
 2 27,3% 417 4.314E-40

Domains

Domains [InterPro]
PET_M15
Unannotated
Unannotated
Disordered region
Representative sequence (used for alignment): 5hxHI (559 AA)
Member sequence: M4W627 (315 AA)
1 559 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF13539

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage FF47
[NCBI] 		1305710 Mapvirus > Mapvirus Ff47
Host Mycobacterium avium subsp. paratuberculosis ATCC 19698
[NCBI] 		1074454 Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium avium complex (MAC)
Host Mycobacterium avium subsp. paratuberculosis
[NCBI] 		1770 Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium avium complex (MAC)

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JX901189 [NCBI]
CDS location
range 23066 -> 24013
strand +
CDS
ATGGCCTTTATTCAGAAGCAGGGGTATTGGATCTCTGAGAATGGTTGGCGAATGTGCGACACCGCCGAGCTGGATTACTCAGCGATCCCCGGAACAGACTTCAAGCTCGGTGTTCGCAAGGGTGCCCCGTCGGTGATCCTCAAGGCGCTCATCTGGCGCCTGCATCGGATCGAACCGATGATTACCACACAGATCGGCTGCTACACCTCGTCGAACTCGATGGCGAACAGCAATCACAACTCTGCTACTGCCATCGACTACAACTGGAACCTTCATCCCTACCAGAAGTGGGGAACGTGGGGTAGCAAGCGCCCCGCAGTGGATCAGGTCATCAAGGACTTCCGGGGCATTGTCGAGTTCGGCGGCGACTGGACCTCACCGCGTGACGAGATGCACTTTGAGCTCCACTTCGCGGAGGGCCATGCCGGCACTGAGCAGCTCGCTACGGACTTGCGCAACGGCCTCTGGGGTATCTACGCGGATGGCACTGCGCCGCCGCCTGTCGTGATCCCTGAGGGCTACTTGCAGCTCGGCTCCGAGGGCGATCAGGTGCGCAAGCTCCAGGCCGGGATGAACAAGGTCTTCCGGAACTACAAGGCCATGCCTCTCGACGAAGACGGCATCTTCGGTGCCTTCACTGAGTCGGCGGTCAAGGAGTTCCAACGGCGTTCGCTGATCGGTGTGGACGGTATCGTCGGGCCCGAGACGAAGCAGCGCTTGGCGACGTACGGAATCATCCTCGATGGGGCGACTGAGCCGACCTCACCGCCTCCTCCTGTTGTCCCCTCGTTCGTCTATCCGTCGACCGACGAGATGGTCAAGCAGGTTTGGGAGCAGCACTTCGGCCCGAAGGCAGAAGGCTGGCCACAGCTCGGCCAGACTCCCGAAGGAAAGAATCGCTACCTCGTTGATGGGGTAGCGTCACTTATCGCCAAGGAGGAAGCGTGA

Gene Ontology

Description Category Evidence (source)
GO:0008233 peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0002c50898_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5hxHI) rather than this protein.
PDB ID
5hxHI
Method AlphaFoldv2
Resolution 87.04
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50