Protein

Protein accession
H9C148 [UniProt]
Representative
8xARZ
Source
UniProt (cluster: phalp2_17800)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MDITLFDVLKLEEGYREKVYRCSEGYPTIGIGTKIGPKDAPLSNYTFKVSQRVAKVMLDDEVVDIIGRLNGTPWYHSLDESRQLIIQSMCYQMGVDGVLKFRKMIDALSRGHWDEAASQALDSLWARQTPKRANRHAEVLRSGDLNAVYEGLLL
Physico‐chemical
properties
protein length:154 AA
molecular weight:17464,8 Da
isoelectric point:6,30
hydropathy:-0,31
Representative Protein Details
Accession
8xARZ
Protein name
8xARZ
Sequence length
243 AA
Molecular weight
27659,76910 Da
Isoelectric point
9,04828
Sequence
mnyverkrkeiktayaiiltlfvafcfafgaliadtqavefkvepkvnldpvlklntdkiclnynctkyavpviipttlspleqhwnsltsklvtvleseegfrsnpylgpegfihvgfgtklhnkkgllpkdfpikisrelatewlhsevaikdlrmsqgkyadiyskldeekqavilsmsyqlgtsgvkrfkkmwaalevgdydtaavemldsrwarqtpqraarhvrimkgsdidyvysk
Other Proteins in cluster: phalp2_17800
Total (incl. this protein): 6 Avg length: 168,2 Avg pI: 8,11
Protein ID Length (AA) pI
8xARZ 243 9,04828
A0A5P8PRF3 163 9,05286
A0A2I7R771 145 9,51336
A0A9P0VF73 152 8,43686
A0A9Y1HTV0 152 6,30193
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_24334
3Qw2p
 463 31,4% 159 2.938E-25
2 phalp2_16834
1uDRT
 24 32,6% 147 2.546E-24
3 phalp2_17399
4Mm73
 7 26,6% 169 2.200E-23
4 phalp2_7697
6I6lz
 232 29,4% 156 4.072E-23
5 phalp2_32005
5iHOn
 21 29,7% 168 2.578E-22
6 phalp2_24213
2KXlJ
 83 32,9% 155 3.505E-22
7 phalp2_35438
8DSMF
 6 33,3% 150 8.522E-18
8 phalp2_33457
7eghX
 14 30,5% 154 3.271E-16
9 phalp2_3146
81Qco
 2 25,3% 158 6.753E-15
10 phalp2_35882
4PmGA
 1 25,2% 174 6.753E-15

Domains

Domains [InterPro]
Disordered region
GH24
Representative sequence (used for alignment): 8xARZ (243 AA)
Member sequence: H9C148 (154 AA)
1 243 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Vibrio phage vB_VchM-138
[NCBI] 		1127518 No lineage information
Host Vibrio cholerae
[NCBI] 		666 Proteobacteria > Gammaproteobacteria > Vibrionales > Vibrionaceae > Vibrio >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
JQ177064 [NCBI]
CDS location
range 43135 -> 43599
strand +
CDS
ATGGATATCACACTGTTCGACGTTTTAAAGCTTGAAGAAGGTTATCGGGAAAAAGTTTACAGATGTAGCGAGGGTTACCCGACAATAGGTATCGGTACGAAAATTGGACCTAAGGATGCACCGCTATCAAACTATACTTTCAAGGTTAGCCAACGTGTCGCAAAAGTGATGCTTGATGATGAAGTGGTAGATATTATCGGTCGTTTAAATGGCACTCCGTGGTATCATTCGCTTGACGAATCACGCCAACTTATCATTCAATCAATGTGCTATCAAATGGGCGTAGATGGTGTGCTGAAGTTTCGTAAGATGATCGACGCATTATCTCGCGGCCACTGGGATGAGGCGGCTAGTCAGGCGTTAGATAGCCTGTGGGCTAGACAAACACCTAAACGTGCAAATCGTCATGCAGAAGTGCTCCGCAGTGGTGACTTAAACGCAGTGTATGAGGGTTTATTATTATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
upi0002536e2d_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8xARZ) rather than this protein.
PDB ID
8xARZ
Method AlphaFoldv2
Resolution 76.03
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50