Protein

Protein accession
U3PJ04 [UniProt]
Representative
8nhz5
Source
UniProt (cluster: phalp2_21498)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTKFDLMADVSSYQLDTKEFFQALKDKGVKAVAVKITEGSNPGSAYVNPKAKNQIKNARAAGLKVHAYHYAKFNGVADAQAEADWFVKNAKKLGIGEDSVMVLDYEDHATARANGTADINAFIQRVKNAGYPKTDIYSMRSWFEDGHIDRKKIIPKNVWVASYGTSNPGLDDVGTWQFTSEYPVSGIKVDMSYDFKGLYTKGSQSSKKPSVAKDKKKDQAGEWHSEKGTFTLGQAIYLRTAPSTGAVPISLVKAGSKINYDAYAIQGGYVWIRQPRSNGYGYMATGYAKNGKRLDYWGKFS
Physico‐chemical
properties
protein length:301 AA
molecular weight:33247,1 Da
isoelectric point:9,47
hydropathy:-0,56
Representative Protein Details
Accession
8nhz5
Protein name
8nhz5
Sequence length
165 AA
Molecular weight
18587,70420 Da
Isoelectric point
9,12442
Sequence
MGLLVHGYHYARFNGNQDARNEAKWFVDHAKQFGLGPESVLALDIEDKANAKYATSDANAFLQAVKDAGYPKIDIYSMASWFWQGRLNAAQLIAKNKWVANYGVSQPGVDNVGLWQFTNTYNIAGNEVDMSYDFSGFILTPALRQSLRRLSTRQRLSQSLYLRLG
Other Proteins in cluster: phalp2_21498
Total (incl. this protein): 8 Avg length: 285,6 Avg pI: 9,32
Protein ID Length (AA) pI
8nhz5 165 9,12442
A0A075KJI2 300 9,32008
F8J1A5 301 9,51039
A0A2P1CCE6 301 9,36553
A0A075KJD2 301 9,41724
A0A075KQK4 300 9,46526
A0A8S5S759 316 8,92205
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32681
81Xxy
 1 38,3% 112 1.186E-15
2 phalp2_6251
6F8cA
 2 27,5% 120 6.192E-07
3 phalp2_5668
4yhqW
 7 28,1% 128 1.294E-05
4 phalp2_39219
3xEyz
 21 33,3% 111 5.868E-05
5 phalp2_20117
23DDy
 70 33,7% 148 5.868E-05
6 phalp2_22092
5WvnN
 1 28,6% 143 1.073E-04
7 phalp2_24174
2ojoF
 57 25,1% 147 6.515E-04

Domains

Domains [InterPro]
GH25
Disordered region
Representative sequence (used for alignment): 8nhz5 (165 AA)
Member sequence: U3PJ04 (301 AA)
1 165 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage phiLdb
[NCBI] 		1399942 Cequinquevirus > Cequinquevirus Ldb
Host Lactobacillus delbrueckii
[NCBI] 		1584 Firmicutes > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KF188410 [NCBI]
CDS location
range 32616 -> 33521
strand +
CDS
ATGACTAAGTTTGATTTAATGGCTGACGTGTCAAGTTATCAACTAGACACAAAAGAGTTCTTTCAAGCATTGAAGGACAAGGGCGTTAAGGCGGTAGCCGTAAAAATTACTGAGGGTTCTAATCCGGGATCAGCTTACGTTAATCCAAAGGCTAAGAACCAAATCAAGAATGCACGGGCGGCAGGACTGAAAGTTCATGCTTACCATTATGCGAAATTTAATGGCGTGGCGGACGCACAAGCTGAGGCTGATTGGTTCGTTAAGAATGCTAAGAAGCTAGGTATTGGCGAAGATTCAGTTATGGTTCTCGATTATGAGGATCATGCAACTGCTAGAGCAAACGGGACAGCTGACATCAATGCCTTTATTCAAAGAGTAAAGAACGCAGGTTATCCTAAGACAGACATCTACTCAATGCGGTCATGGTTTGAGGACGGTCATATTGACCGTAAGAAGATCATTCCTAAAAACGTTTGGGTAGCGTCATACGGTACTAGCAATCCGGGTCTTGATGACGTAGGGACTTGGCAATTCACAAGCGAGTATCCAGTCAGTGGGATTAAGGTAGACATGAGCTACGACTTCAAGGGATTATATACCAAGGGTAGTCAAAGCTCAAAGAAGCCTTCTGTCGCTAAGGACAAGAAGAAGGATCAAGCCGGAGAATGGCACTCAGAAAAGGGGACGTTCACGTTAGGGCAGGCTATTTATTTAAGAACAGCACCAAGCACGGGAGCAGTTCCTATTTCACTGGTAAAGGCAGGAAGCAAGATTAACTATGATGCTTATGCTATTCAAGGAGGTTACGTCTGGATTAGGCAACCGAGATCCAATGGCTATGGCTACATGGCAACGGGATATGCGAAGAATGGCAAGCGGCTAGATTATTGGGGTAAATTCAGTTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0003b10944_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8nhz5) rather than this protein.
PDB ID
8nhz5
Method AlphaFoldv2
Resolution 85.07
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50