Protein

Protein accession
D4P733 [UniProt]
Representative
1NTeW
Source
UniProt (cluster: phalp2_10392)
Protein name
LysA
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MAYIEILSPNKHYKGFKKNIIVLHTNEPGPYAPGKFPGTAESLGLYLKDPSRQASYQLIVDRNGDVCRSVRDTDCAWAAGPIANNEGLHICVNGWAAQTRAEWLQYDKQLNQTAVEIARWCKQEGIPAKKLTPAMFKDAEWGIGGHGDVALAWRETDHTDPGANYPYDVLIQKVLAILNPAPPAGNAGNGAAKMSDEMIQFMGPSGDGWIELAPQKDPQGKSFSIFKFLQGKEPNVKKQTVVEAIATLIFEATLRIRPYRGKDADRVPETVLGHAATAAGTGLDNRELLLQVLLNQQAIAEKVGVALPDITLQGQPVPGELLGEPARKE
Physico‐chemical
properties
protein length:329 AA
molecular weight:35810,4 Da
isoelectric point:6,12
hydropathy:-0,34
Representative Protein Details
Accession
1NTeW
Protein name
1NTeW
Sequence length
342 AA
Molecular weight
37710,07390 Da
Isoelectric point
5,81545
Sequence
MAYIEIWSPNKYAGAGGYKKSIIVVHTNEAGPYAYQKFPGDARSLGKYLSQSHVQASYHKCVDRNGDVCRMLVDVDRAWAAGNVGNNEGLHLCVLGWAAQSREEWLSFPQQLDQVGREIAIWCKQEGIPADKLNAAQLKDGTWGVAGHGDVAQAWRETDHTDPGPNFPYDYVLNVAKRELGQSEGDISVADGAFLVDQMMGADGRKGWKELAPQRNPEGKRFSIFKYLRGEEPNVERQTVVEAIATLVFEATLRILPYRKNNVPKTPETVLGHAAAAHGVSLDNRSLLLALAEAQIDLCKKVNAEPYAPLVAIVREYRGYEQPAETAKLSPLDPAWTPPEQG
Other Proteins in cluster: phalp2_10392
Total (incl. this protein): 11 Avg length: 396,0 Avg pI: 6,31
Protein ID Length (AA) pI
1NTeW 342 5,81545
7Qd8F 329 6,12124
A0A1I9SA50 466 5,44315
A0A2U8UJS9 465 5,27116
A0A2U8ULA6 466 5,34738
A0A889IRI5 309 4,86874
A0AA96H259 309 7,03436
A0AA96JZC4 447 7,80694
A0AA96K597 447 7,80694
A0AA96KAL5 447 7,80694
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9233
6TsmW
 1 23,9% 213 5.285E-09
2 phalp2_32212
71H4R
 9 21,0% 219 2.036E-06

Domains

Domains [InterPro]
Ami2
Unannotated
Disordered region
Representative sequence (used for alignment): 1NTeW (342 AA)
Member sequence: D4P733 (329 AA)
1 342 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Rhodococcus phage ReqiDocB7
[NCBI] 		691966 No lineage information
Host Rhodococcus equi
[NCBI] 		43767 Actinobacteria > Actinobacteria > Corynebacteriales > Nocardiaceae > Rhodococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
GU580940 [NCBI]
CDS location
range 32628 -> 33617
strand +
CDS
ATGGCGTACATTGAAATCCTCTCCCCCAATAAGCACTACAAGGGGTTCAAGAAGAACATCATCGTTCTTCACACGAACGAGCCTGGCCCCTACGCGCCTGGCAAGTTTCCTGGTACTGCCGAGTCTCTTGGCCTGTACCTTAAGGACCCTTCTCGTCAGGCAAGCTACCAGCTTATCGTGGACCGCAACGGCGACGTGTGCCGAAGTGTGCGGGACACCGATTGCGCATGGGCGGCGGGGCCGATTGCCAACAACGAAGGCCTTCACATTTGCGTGAACGGCTGGGCAGCTCAGACCCGCGCAGAGTGGTTGCAGTACGATAAGCAGCTCAACCAGACGGCGGTTGAGATTGCACGCTGGTGCAAGCAGGAAGGCATTCCCGCAAAGAAGCTTACCCCCGCAATGTTCAAGGATGCGGAGTGGGGCATCGGCGGACACGGCGACGTTGCGCTTGCGTGGCGAGAGACAGATCACACTGACCCAGGAGCAAACTACCCGTATGATGTGCTGATTCAGAAGGTGCTTGCCATTCTGAATCCCGCACCGCCTGCGGGCAATGCCGGAAACGGAGCAGCAAAGATGAGCGATGAGATGATCCAGTTCATGGGTCCGAGTGGTGACGGCTGGATTGAGCTTGCACCACAGAAGGACCCCCAGGGCAAGTCGTTCTCGATCTTCAAGTTCCTTCAGGGCAAGGAACCGAACGTCAAGAAGCAGACGGTTGTCGAGGCAATCGCTACGCTTATCTTTGAGGCTACGCTTCGCATCCGCCCGTACCGGGGCAAGGATGCAGACCGCGTACCTGAGACCGTCCTTGGTCACGCGGCAACGGCAGCCGGTACCGGCCTTGACAACCGCGAACTGCTGTTGCAAGTGCTGCTGAATCAGCAGGCCATTGCTGAGAAGGTCGGCGTTGCCCTTCCGGACATAACTCTACAGGGTCAGCCGGTCCCCGGAGAGCTTCTTGGAGAGCCTGCACGTAAGGAGTAG

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0001cdd75d_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (1NTeW) rather than this protein.
PDB ID
1NTeW
Method AlphaFoldv2
Resolution 82.46
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50