Protein

Protein accession
K9RZW8 [UniProt]
Representative
2V9bD
Source
UniProt (cluster: phalp2_21647)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGMKQRLAYCSIGAVLSIIATVYPNELKTSERGLAHIAKWEQCVSCTYKDHIGVSTIGMGATRDFNGKAPQPGRKLSDDEVARLFIRDIKSAEQCVLERMDGAAMPQSVFDASVSLIHNTGCAGATYNSKRKAKTNLRLQAEAHNWKQVCYRMGDFIYAGGVVSKGLVNRRADDQKLCLEDL
Physico‐chemical
properties
protein length:182 AA
molecular weight:20032,8 Da
isoelectric point:8,97
hydropathy:-0,28
Representative Protein Details
Accession
2V9bD
Protein name
2V9bD
Sequence length
370 AA
Molecular weight
41052,21920 Da
Isoelectric point
10,61764
Sequence
MGRIASRFPTRRGKRLQMSVEGIAFLLREEGLAVKAYRDSQGVWTIGVGHTAAAGAPRPRAGMHLTQEAAVRLMATDLRRYERRVRRALGGREVPQHVFDALVSFDYNTGGIHKASFLKPLMQGRLREAETRFMWWRRPDDVIPRRRRELALWRDADYDDLSKATLWTADDSGRPVASGVFDPLELAQRALRERAPVADALDHGMVKAVQRKLKELGYHEVGAVDGIAGPRTRAALNAWLLDHGYQPVRDVYALDDDVRADLLTANRGRPESPQRETATAADLRRAGSTDIRRADWGLAGGTGLAMLGAVGETARRVGDSLDSIASPIRLFIADNATAILIAAGIAGAALAWTWRRNRVRRHREGSYVSR
Other Proteins in cluster: phalp2_21647
Total (incl. this protein): 9 Avg length: 230,4 Avg pI: 9,34
Protein ID Length (AA) pI
2V9bD 370 10,61764
15vgw 414 9,57086
A0A2P9JZU6 182 8,45156
A0A3G8F2G6 182 9,33981
A0A1W5P530 182 9,31873
A0AAE7P9K8 190 9,21023
A0AA47NCT3 182 9,21068
A0AA48R2E6 190 9,38694
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36335
j9L3
 5 32,5% 369 1.525E-33
2 phalp2_9590
1qPJJ
 8 33,2% 280 2.924E-27
3 phalp2_38866
1Mo76
 29 31,8% 358 5.811E-26
4 phalp2_24666
5IWY5
 127 40,1% 239 2.790E-24
5 phalp2_16965
86QY9
 61 29,0% 231 6.837E-18
6 phalp2_1642
8qFOb
 229 29,7% 245 5.231E-17
7 phalp2_13759
6PI4E
 57 31,1% 315 4.755E-09

Domains

Domains [InterPro]
GH24
Unannotated
Disordered region
Representative sequence (used for alignment): 2V9bD (370 AA)
Member sequence: K9RZW8 (182 AA)
1 370 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Cronobacter phage vB_CskP_GAP227
[NCBI] 		1264737 Autographiviridae > Cronosvirus > Cronosvirus GAP227
Host Cronobacter sakazakii
[NCBI] 		28141 Proteobacteria > Gammaproteobacteria > Enterobacteriales > Enterobacteriaceae > Cronobacter >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KC107834 [NCBI]
CDS location
range 40112 -> 40660
strand +
CDS
ATGGGAATGAAACAAAGACTCGCTTACTGCTCCATCGGTGCGGTACTGAGTATCATCGCTACTGTCTATCCCAATGAGCTGAAAACCTCTGAACGAGGCTTGGCCCATATCGCTAAATGGGAGCAGTGTGTAAGCTGCACCTACAAAGACCACATCGGTGTCAGCACTATTGGAATGGGCGCTACGCGGGACTTCAACGGTAAGGCTCCTCAGCCGGGCCGTAAGCTGTCCGACGATGAGGTGGCCCGTCTGTTCATCCGCGACATTAAATCCGCTGAGCAGTGCGTTCTGGAGCGTATGGACGGTGCTGCGATGCCTCAGTCGGTATTCGATGCCTCCGTATCCCTGATTCACAATACCGGGTGCGCCGGGGCAACCTACAACAGCAAGCGTAAGGCTAAGACCAACCTCCGGCTGCAAGCTGAGGCCCACAACTGGAAGCAGGTCTGCTACCGCATGGGTGACTTCATCTACGCTGGTGGTGTGGTTTCCAAAGGCCTGGTTAACCGCCGCGCTGACGACCAGAAGCTATGCCTGGAGGACTTATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0002a83116_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2V9bD) rather than this protein.
PDB ID
2V9bD
Method AlphaFoldv2
Resolution 76.82
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50