Protein

Protein accession
Q6J1Q5 [UniProt]
Representative
8oyxl
Source
UniProt (cluster: phalp2_14090)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MARIDIASAGGRNRVAFLDTIAVSEIGGTLLAKSDDGYNVLVGSTPARPLLFTSYAAHPNVLNRQISVPSTAAGRYQILARWWRIYQAQMKLPDFGPVSQDRYALRQLREHGALPLIDAGRFCEAVAKVSNVWASLPGAGYGQHENKMEHLLATYVLAGGEVTA
Physico‐chemical
properties
protein length:164 AA
molecular weight:17766,1 Da
isoelectric point:9,16
hydropathy:-0,03
Representative Protein Details
Accession
8oyxl
Protein name
8oyxl
Sequence length
218 AA
Molecular weight
22078,30190 Da
Isoelectric point
4,98975
Sequence
MSKPAAAALLLLAAGLAYAYQGAATPAEPADTEGTGDDWLASLFGGDSGAGAASPVIGGLGDLLGLGATVIPAGNDANRAAFLAMIRQSEGTAGANGYRTYYGGSLFDSFADHPNVKHRVFGITSTAAGAYQFLYSTWKECQRALSLPDFSPASQDQAALYLLKRSGALAAIDAGQFTRAVQLAAPTWASLPGAGYGQHENPLASLQAAYQSAGGTVA
Other Proteins in cluster: phalp2_14090
Total (incl. this protein): 17 Avg length: 183,6 Avg pI: 5,80
Protein ID Length (AA) pI
8oyxl 218 4,98975
2S84q 162 6,90721
3iO4p 153 7,80623
4NR8F 162 6,27550
4dNke 166 7,82164
4dmQn 156 6,12124
5BEp3 152 5,55831
5IGe5 160 5,11457
5odMy 161 5,51369
6DzIW 213 4,93257
6F9tc 227 4,93933
6JbGN 217 4,58113
6KHtf 225 4,80934
6N9Bo 218 4,82770
7e9va 152 4,96281
7ox5C 216 4,32189
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15310
1iZB6
 260 51,6% 151 9.750E-63
2 phalp2_22274
7tL4I
 47 47,0% 151 5.321E-57
3 phalp2_14292
3zJio
 170 44,9% 149 2.563E-56
4 phalp2_8549
1DMQs
 2433 44,3% 160 9.012E-56
5 phalp2_10185
wALc
 11 44,3% 212 1.006E-53
6 phalp2_4748
7I1R1
 83 43,9% 157 9.095E-47
7 phalp2_26312
17V0j
 3 46,4% 185 1.111E-42
8 phalp2_29942
8nkTU
 3 45,7% 175 1.521E-42
9 phalp2_34051
89Glt
 18 44,0% 161 2.989E-34
10 phalp2_25045
15ncl
 14 43,7% 144 3.238E-32

Domains

Domains [InterPro]
Disordered region
Unannotated
Representative sequence (used for alignment): 8oyxl (218 AA)
Member sequence: Q6J1Q5 (164 AA)
1 218 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Burkholderia phage BcepC6B
[NCBI] 		2883949 Ryyoungvirus > Ryyoungvirus bcepC6B
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AY605181 [NCBI]
CDS location
range 22679 -> 23173
strand +
CDS
GTGGCGCGCATTGATATTGCATCGGCCGGTGGGCGCAACCGTGTTGCGTTCCTCGACACGATCGCCGTGAGCGAGATCGGCGGGACACTGCTCGCGAAGTCGGACGACGGCTACAACGTGCTCGTTGGCTCGACGCCGGCGCGGCCGCTGTTGTTCACGAGCTACGCGGCGCATCCGAACGTGCTCAACCGGCAGATCTCGGTACCATCGACGGCCGCCGGCCGCTATCAGATCCTCGCGCGCTGGTGGCGCATCTATCAGGCGCAGATGAAGCTACCGGACTTCGGACCGGTATCGCAGGACCGATACGCTCTGCGGCAGCTGCGCGAGCATGGCGCGTTGCCGCTGATCGACGCCGGTCGCTTCTGCGAGGCGGTGGCGAAGGTATCGAACGTATGGGCCAGTCTGCCAGGAGCCGGGTACGGGCAGCACGAAAACAAGATGGAACATTTGCTGGCCACGTACGTGTTGGCTGGCGGTGAGGTGACGGCGTGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016829 lyase activity molecular function None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
4.2.2.n2 None Endolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan with concomitant formation of a 1,6-anhydrobond in the MurNAc residue. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04109

Tertiary structure

PDB ID
upi0000377f53_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8oyxl) rather than this protein.
PDB ID
8oyxl
Method AlphaFoldv2
Resolution 73.14
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50