Protein

Protein accession
A0A0N9SGQ7 [UniProt]
Representative
2lNi2
Source
UniProt (cluster: phalp2_34144)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MKARDMSVSDNGVNFVKSFEGYFQDAYWDKWGSVWTIGYGHTKGVKRGDRLENEREAHNILKRDLDSHMIIPKQDITSNLSQSQYDALTSFAFNLGASIFRNNRNLLDAINSSNWNEASRIMKLFNRAGGQVLPGLTRRRNAEADMMLKTDEGQPTATETYDSSWFTKETGVFKLDSNIKLRTAPFTGATVLATLPIDSLVNYDAYGIEQDGFVWIRQPRSNGYGYLATGETRNGKRIDTWGSFK
Physico‐chemical
properties
protein length:245 AA
molecular weight:27737,6 Da
isoelectric point:8,67
hydropathy:-0,62
Representative Protein Details
Accession
2lNi2
Protein name
2lNi2
Sequence length
106 AA
Molecular weight
11704,73900 Da
Isoelectric point
5,32675
Sequence
LIGSKSLEWFTGVEETIATSQYDSSWFTKQDGVLTLNTSIKLRTEPSADAPVIATLNAGDEVKYDAFGYEKDGHVWLRQKRSDGYGYIASGETSNGKRVSSWGSFK
Other Proteins in cluster: phalp2_34144
Total (incl. this protein): 9 Avg length: 159,1 Avg pI: 7,93
Protein ID Length (AA) pI
2lNi2 106 5,32675
2VHE1 68 9,75337
4lwcG 78 9,39383
5oFNi 78 8,24765
89f3Q 85 9,62818
A0A1X9SGL2 244 6,90636
A0A1W6JSI0 244 6,90585
A0AAE8YSH8 284 6,58493
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17508
5tTvS
 1 42,6% 82 2.267E-22
2 phalp2_6949
2VNdf
 3 47,2% 74 2.007E-17
3 phalp2_23379
5JYK7
 2 34,5% 81 1.074E-10
4 phalp2_24122
7onUQ
 2 33,3% 78 9.140E-06
5 phalp2_33433
72wvZ
 1 34,8% 66 2.891E-04

Domains

Domains [InterPro]
Disordered region
SH3_3
Representative sequence (used for alignment): 2lNi2 (106 AA)
Member sequence: A0A0N9SGQ7 (245 AA)
1 106 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Bacillus phage VMY22
[NCBI] 		1734382 Salasmaviridae > Mingyongvirus > Mingyongvirus VMY22
Host Bacillus cereus
[NCBI] 		1396 Firmicutes > Bacilli > Bacillales > Bacillaceae > Bacillus > Bacillus cereus group

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KT780304 [NCBI]
CDS location
range 14942 -> 15679
strand +
CDS
ATGAAAGCTAGAGACATGAGTGTATCTGATAACGGTGTTAATTTTGTAAAGAGTTTTGAAGGTTATTTTCAAGATGCTTACTGGGACAAATGGGGTTCTGTTTGGACGATTGGTTATGGACATACAAAAGGTGTTAAACGTGGTGACAGATTAGAAAATGAACGAGAAGCGCACAACATTTTAAAAAGGGATCTTGACTCACATATGATTATCCCGAAACAAGACATTACTTCTAATTTGAGTCAATCACAATACGATGCGTTAACGAGTTTCGCTTTTAACTTGGGCGCTAGTATATTCCGTAATAACCGTAATTTATTAGATGCTATCAATTCTAGTAACTGGAATGAAGCGTCAAGAATTATGAAATTGTTCAATCGTGCGGGTGGTCAAGTATTACCAGGATTAACAAGAAGAAGAAATGCTGAAGCTGATATGATGTTAAAGACGGATGAAGGACAACCAACGGCAACCGAAACTTATGATTCTAGTTGGTTCACGAAAGAAACAGGAGTGTTCAAACTAGATTCTAATATTAAACTACGAACTGCACCGTTTACAGGAGCTACGGTTCTTGCGACTCTACCAATAGATAGTTTAGTTAACTACGATGCTTACGGAATTGAGCAAGATGGTTTTGTTTGGATACGACAACCGAGAAGTAACGGTTATGGTTATCTTGCAACTGGTGAGACTAGAAACGGAAAACGTATAGATACGTGGGGTTCATTTAAATAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
A0A0N9SGQ7
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2lNi2) rather than this protein.
PDB ID
2lNi2
Method AlphaFoldv2
Resolution 82.96
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50