Protein

Protein accession
R9RWH6 [UniProt]
Representative
8MIMB
Source
UniProt (cluster: phalp2_11453)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTEKVLPYDRAIVPQETGWWCGPAATQVVLNSRGIIVPEATLAAEIEAIENPGRGDDRDGTDYVGLIEQVLDRRVPAARYTSVYLTNDPPTQAQKDRLWEHIVRSIDAGYGVVMNWVAPPSNKPRGVKGSVSPRYSGGTTYHYVACMGYDDTPGARAVWIADSGFQPQGYWISFDQCATLIPPKGYAYADAAPAAPAPAPTPTPLLAAAPILARAAGISEAKAREILPTMRDGLKQADCTTVNRIAMFIAQTGHESDDFRATEEYANGPLNQERWIYKGRTWIQITWREHYARFGKWCFDRGLVTDPDVFVKNPRALADLKWAGIGAAWYWTVERPDINVLCDRRDIETVSRRINGTNPNTGRANHIEERIARWNRALAVGDDLLQLIREEEDGFLSALTPAEQRALYNEIMKKGPTRSFMAEDQNQIETLLGFVYNIDGNIWNDAVTRAYLFDVPLAVEYVERVARDGVHPKSWAFQQLDGKGERWLAKFGQEYCKGLIRFKKKLNDLLEPYGEN
Physico‐chemical
properties
protein length:516 AA
molecular weight:57898,7 Da
isoelectric point:5,63
hydropathy:-0,43
Representative Protein Details
Accession
8MIMB
Protein name
8MIMB
Sequence length
456 AA
Molecular weight
49180,98030 Da
Isoelectric point
5,67062
Sequence
MAEKLLPYDRSIVPQETGYWCGPAATQVVLNSRGIIKAESDLARQIGTTTRGTDYVGLIERVLDAIVPDARYTSVYIENDPPTAAQKETLWRNLVASINAGYGVVMNWVAPPSNKPRGVKGSVSPSYSGGTTYHYVAAMGYDDNPAARAVWIADSGFRPYGYWVSFDQCATLIPPKGYCYAAAAPAAPAAPSAPAPAAQLSTKDQHALTIMRKGQEMGITPRGIKIALAVALVESNITVYANPKVPESMVIPHEAVGNDGRSVGIFQQQVVWGNGAWWWGDAATCMDPASSAALFYDRLLKLDYNNTSRSPGSYAQSVQQSAYPTRYDERFAEAEQLYVRLISQVTPADPIEELLMSNLRVPSLSIYATPGEPDVPIIDMIRALDAHGDHESYVERQALLGDTDAIARIVRTAAGKGKYGNAPGPVNQAKDALKQIEAVNPAALKQFLDNQKGSVA
Other Proteins in cluster: phalp2_11453
Total (incl. this protein): 173 Avg length: 514,3 Avg pI: 5,58
Protein ID Length (AA) pI
8MIMB 456 5,67062
171Ur 453 6,51741
1I1dT 433 5,24524
7As3I 451 5,52597
7AsRx 451 5,66153
7Q1Iw 502 6,04815
7ZSXT 461 5,86353
7jyTJ 454 5,66698
7pZeQ 457 5,01021
7zQXg 453 5,66693
8Ilx6 502 5,69790
8Ilxa 454 5,93464
8MmwX 502 6,04610
A0A4Y6EWN4 456 5,67062
A0A345M6H3 207 5,89900
A0A249XU47 525 5,20460
A0A2H4PCY0 499 5,58048
A0A514DDJ1 546 4,98952
A0A482JFG7 516 6,89812
A0A2R4A258 521 5,53364
A0A6M3T401 517 5,44531
A0A2H4PFT0 499 5,44582
A0A3S9UNQ2 516 5,63169
A0A3G3M9P4 239 9,13532
A0A5Q2WGF8 239 9,34406
A0A7G8LIK8 249 9,19134
A0A7G9UZC3 239 9,26786
A0A2P1JS46 551 5,22319
A0A222ZPI5 567 5,82562
A0A5J6TTI2 557 5,06591
A0A222Z087 538 5,02141
A0A5J6TKV3 567 5,46452
A0A7G8LLY0 567 5,48044
A0A5P8D714 561 5,18056
A0A482JIX2 558 5,31072
A0A514TWW3 451 5,52597
A0A385D503 561 5,19602
A0A6G8R216 451 5,66153
A0A5J6TEX3 550 5,31754
A0A5J6TK43 548 5,01322
A0A5J6TL22 551 5,22319
A0A0F6YQN9 516 6,50661
V5UQ90 557 5,20591
A0A142K7M8 502 6,04815
A0A0A0RRL8 549 5,06784
A0A023W6V3 569 5,30310
A0A088F7M0 454 5,66698
A0A649VDP2 523 5,40876
A0A142ULM3 453 5,66693
A0A1I9SD57 515 5,44940
A0A2U8UM53 514 5,53131
A0A1D8ESW4 520 5,63396
A0A1I9S467 538 4,97656
R9R591 521 5,46873
G1DA58 521 5,95027
A0A076YJT5 514 5,53131
A0A097BYL6 520 5,42769
A0A2R4AQT9 521 5,62731
G1FTW6 502 5,69790
A0A345L1B9 514 5,53131
A0A1D8EX27 454 5,93464
A0A222ZML5 567 5,59002
A0A222ZRQ6 548 5,19369
A0A249XT04 551 5,16186
G1BPX9 551 5,10144
A0A068F335 551 5,22319
A0A0N9BDL4 495 6,06156
G1BRA8 521 5,58053
A0A2H4PA12 531 6,77296
A0A2H4PA14 533 6,18393
A0A516KUE5 518 5,62896
A0A515MGW9 221 9,07678
A0A023W7C5 519 5,68648
A0A142K791 502 6,04610
A0A515MLQ4 527 5,61543
A0A0A7RTE2 514 5,36943
A0A0A7RV55 514 5,36943
A0A0K2CXN7 520 5,63396
A0A142K7G0 451 5,66693
A0A1B1SFI0 514 5,36943
A0A1C9M1S0 551 5,29128
A0A1D8EW81 521 5,83847
A0A1D8EWA4 520 5,63390
A0A1D9CAJ8 514 5,53131
A0A1I9SC79 499 5,55160
A0A1J0MBL5 567 5,82562
A0A1P8DUG5 551 5,15731
A0A221J6T5 514 5,36943
A0A222ZQ64 551 5,15731
A0A222ZS16 551 5,29128
A0A222ZT88 551 5,29128
A0A249XLQ9 551 5,28582
A0A286MRA0 567 5,82562
A0A286RWF9 521 5,95027
A0A2D2W3L7 551 5,15731
A0A2L0HKT9 520 5,63396
A0A2P1CHN6 527 5,61947
A0A2P1JWS4 551 5,15731
A0A2P1JZ08 549 5,06216
A0A2P1N4U0 520 5,63396
A0A2R4A1Y4 521 5,44406
A0A2R4AMJ9 551 5,29128
A0A2S1PAR3 551 5,22319
A0A2Z4Q128 520 5,63396
A0A2Z5H637 527 5,72780
A0A2Z5H704 551 5,28281
A0A2Z5HCE3 514 5,53131
A0A2Z5XV53 521 5,60787
A0A345KNN6 527 5,61947
A0A345KP36 527 5,72780
A0A345KVK8 551 5,22319
A0A345KY04 514 5,36943
A0A345L3Z7 551 5,22319
A0A345L491 551 5,15731
A0A345L528 516 5,62504
A0A385D144 551 5,15731
A0A385UBR6 551 5,15731
A0A3G3MB06 519 5,63396
A0A3G8FRV9 551 5,15731
A0A3Q9R984 520 5,63396
A0A3T0IKE6 527 6,00518
A0A411BMA4 558 5,38131
A0A411C9W2 521 5,56865
A0A411CQD5 499 5,55160
A0A481VYU1 499 5,55160
A0A481VZQ6 499 5,55160
A0A481W191 499 5,55160
A0A482JIV8 520 5,63396
A0A514U0K5 514 5,50772
A0A516KT65 519 5,63396
A0A5J6TIV5 551 5,22319
A0A5J6TLL1 548 5,01322
A0A5J6TPX2 551 5,29128
A0A5J6TUL2 551 5,29128
A0A5J6TUS7 551 5,29128
A0A5P8DA45 527 5,69336
A0A5Q2WGS5 551 5,15731
A0A5Q2WKN7 551 5,15731
A0A649W0Q5 523 5,18817
A0A6B9LDC4 527 5,70160
A0A6G6XL68 551 5,15731
A0A6M3T118 521 5,60787
A0A6M3T1H7 521 5,60787
A0A6M3TBI6 521 5,60787
A0A7G9W274 514 5,44491
E0YPT5 551 5,15731
G1BPN4 551 5,29128
G1BS56 514 5,36943
G3M5B9 499 5,55160
G3MCI0 551 5,29537
Q857L2 514 5,53131
R4JH32 514 5,50772
W0LJZ5 499 5,44582
A0A8A5LMC8 567 5,48533
A0A8F0FQB3 549 5,12321
A0A8F3E619 551 5,21756
A0A976SUD2 551 5,03960
A0A976SUK5 551 5,04562
A0A977PRF7 502 5,85757
A0A9E7DX08 551 5,10729
A0A9E7SG79 551 5,15731
A0AA96GUI1 514 5,53131
A0AA96H664 538 4,97656
A0AA96HE34 514 5,44491
A0AA96KMY3 549 5,06784
A0AA96R2K6 551 5,10354
A0AAE7SPJ6 549 5,01544
A0AAE7WW95 551 5,10729
A0AAE8Y535 549 5,01544
A0AAE8Y5J2 549 5,01544
A0AAE9BRG8 527 5,72780
A0AAF0DNF8 551 4,94553
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9506
1175H
 95 54,2% 339 4.445E-119

Domains

Domains [InterPro]
PET_C39
Unannotated
Unannotated
Representative sequence (used for alignment): 8MIMB (456 AA)
Member sequence: R9RWH6 (516 AA)
1 456 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF13529

Taxonomy

  Name Taxonomy ID Lineage
Phage Mycobacterium phage Jobu08
[NCBI] 		1327772 Microwolfvirus >
Host Mycobacterium smegmatis str. MC2 155
[NCBI] 		246196 Actinobacteria > Actinobacteria > Corynebacteriales > Mycobacteriaceae > Mycobacterium >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KC661281 [NCBI]
CDS location
range 4481 -> 6031
strand +
CDS
ATGACGGAGAAGGTACTCCCCTACGACCGCGCCATCGTCCCGCAGGAGACCGGCTGGTGGTGTGGCCCTGCGGCCACCCAGGTCGTGCTCAACTCGCGAGGCATCATCGTCCCGGAGGCCACGCTCGCCGCTGAGATCGAGGCCATCGAGAACCCCGGACGGGGTGACGACCGCGACGGCACCGACTACGTCGGCCTAATCGAGCAGGTGCTCGACCGCCGCGTCCCGGCTGCCCGCTACACGTCGGTCTACCTGACCAACGACCCGCCCACGCAGGCCCAGAAAGACCGGCTGTGGGAGCACATCGTCCGCTCCATCGACGCTGGCTACGGCGTCGTCATGAACTGGGTCGCCCCGCCGTCGAACAAGCCACGCGGCGTGAAGGGCTCGGTGAGCCCGCGCTACAGCGGAGGCACCACGTACCACTACGTCGCGTGCATGGGCTACGACGACACCCCCGGCGCTCGGGCGGTATGGATCGCCGACAGCGGCTTCCAGCCGCAGGGCTACTGGATCTCGTTTGACCAGTGCGCCACGCTGATCCCGCCGAAGGGCTACGCGTACGCCGACGCCGCACCGGCTGCTCCCGCTCCCGCACCCACGCCGACCCCCCTGCTCGCCGCCGCGCCGATCCTGGCGCGTGCTGCGGGCATCTCCGAGGCCAAGGCCCGCGAGATCCTGCCGACGATGCGTGACGGGCTGAAGCAGGCTGACTGCACCACCGTCAACCGGATCGCGATGTTCATCGCCCAGACCGGCCATGAGTCCGACGACTTCCGGGCCACCGAGGAGTACGCCAACGGTCCCCTGAACCAGGAGCGCTGGATCTACAAGGGACGCACCTGGATTCAGATCACCTGGCGCGAGCACTACGCCCGGTTCGGGAAGTGGTGCTTCGACCGCGGCCTGGTGACCGACCCCGACGTGTTCGTCAAGAACCCGCGTGCGCTGGCTGATCTGAAGTGGGCCGGCATCGGCGCGGCTTGGTACTGGACGGTCGAGCGCCCGGACATCAACGTGCTGTGCGACCGCCGCGACATCGAGACGGTCTCGCGACGGATCAACGGGACGAACCCGAACACCGGACGCGCCAACCACATCGAAGAGCGGATCGCCCGCTGGAACCGCGCACTCGCGGTCGGCGACGACCTGCTGCAACTTATCCGAGAGGAGGAGGACGGCTTCTTGTCCGCACTCACACCCGCTGAACAGCGCGCTCTCTACAACGAGATCATGAAGAAGGGTCCGACCCGGTCGTTCATGGCCGAGGACCAGAACCAGATCGAGACGCTGCTCGGCTTCGTCTACAACATCGACGGCAACATCTGGAACGACGCGGTGACCCGCGCCTACCTGTTCGACGTGCCGCTGGCTGTCGAGTACGTCGAGCGCGTTGCTCGCGATGGCGTCCACCCGAAGTCGTGGGCGTTCCAGCAGCTCGACGGCAAGGGCGAGCGCTGGCTGGCCAAGTTCGGCCAGGAGTACTGCAAGGGCCTGATCCGCTTCAAGAAGAAGCTGAACGACCTGCTTGAGCCGTACGGGGAGAACTGA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi0003424e7e_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8MIMB) rather than this protein.
PDB ID
8MIMB
Method AlphaFoldv2
Resolution 85.87
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50