Protein

Protein accession
A0A4D6AFW1 [UniProt]
Representative
1csV3
Source
UniProt (cluster: phalp2_632)
Protein name
Lysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVINIEQAIAWMASRKGKVTYSMDYRNGPSSYDCSSSVYFALRSAGASDNGWAVNTEYEHDWLIKNGYVLIAENTNWNAQRGDIFIWGKRGASAGAFGHTGMFVDPDNIIHCNYGYNSITVNNHDEIWGYNGQPYVYAYRYARKQSNAKVDNQSVVSKFEKELDVNTPLSNSNMPYYEATISEDYYVESKPDVNSTDKELLVAGTRVRVYEKVKGWARIGAPQSNQWVEDAYLIDATDM
Physico‐chemical
properties
protein length:239 AA
molecular weight:27066,6 Da
isoelectric point:5,13
hydropathy:-0,57
Representative Protein Details
Accession
1csV3
Protein name
1csV3
Sequence length
175 AA
Molecular weight
19778,34730 Da
Isoelectric point
4,95968
Sequence
MGLNLETAIAWMRARKGQVSYSMDDRNGPDSYDCSSSIYYALLSGGAVSAGWAVNTEYEHDWLKKNGYELIAENTPWDAQRGDVFIWGRRGYSSGAGGHTGIFVDSDNIIHCNYRFDGITVNDHDDIWLYAGRPYYYVYRLTNPSAAAEEIKTGWQNDDTGYWFVRANGSHSKDQ
Other Proteins in cluster: phalp2_632
Total (incl. this protein): 60 Avg length: 227,8 Avg pI: 5,89
Protein ID Length (AA) pI
1csV3 175 4,95968
1c0Nj 220 5,53449
1cvuW 102 6,03024
1mqs0 172 6,95507
1o2Iw 259 9,01850
3jTeD 212 6,04997
5HUZP 102 6,54208
5T0KX 228 4,30023
5UPve 102 6,81013
5i1S9 212 5,46509
5tFBy 160 5,73530
60Ara 193 7,00855
61bgX 202 9,00599
6Ygj4 159 5,17851
70emo 106 4,73960
72l2s 218 6,05218
72w2J 147 5,68614
7C4UM 226 5,52591
7Oip6 185 5,02243
7QF5q 102 6,53128
7Z8ND 251 9,46649
7m474 147 5,42860
7rVG0 254 9,09683
7rZvs 247 9,41285
7wYhe 259 9,03623
87a3P 175 5,79146
8IUZ0 294 10,02350
8op7o 250 9,17271
8tSZ6 275 9,21506
D5LO 242 4,55311
D98z 242 4,58409
JVXx 102 4,72471
N0ED 197 4,34593
oGZB 119 4,81315
A0A4D6A237 454 6,11345
Q9AF60 295 4,72783
A0A4D6A7M4 239 5,12900
A0A4D6BBH7 238 4,57789
A0A4D6A8W6 295 4,93768
A0A1S5S9Z7 295 5,79277
A0A1U9WRD0 295 4,81411
A0A4D6AB26 239 4,66650
A0A4D6A2A2 239 5,12900
A0A4D6A3T3 239 5,12900
A0A4D6A9G7 239 5,12900
A0A4D6ACP0 239 5,12900
A0A4D6AZZ6 239 5,12900
A0A4D6B027 239 5,12900
A0A4D6B1Q0 239 5,12900
A0A4D6B4E5 239 5,12900
A0A4D6B8J4 239 5,12900
A0A7L8ZKD4 295 4,87493
E7DNC3 296 4,94882
O03979 296 4,94882
A0A8S5LRY0 301 4,91421
A0A8S5PGC3 307 4,74398
A0A8S5TT64 295 5,19931
A0A8S5UA30 295 5,19931
A0AA96IX20 307 4,83270
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_9275
76k47
 345 75,4% 167 1.330E-85
2 phalp2_20987
7y6FJ
 38 45,8% 168 6.386E-55
3 phalp2_13886
7C1QD
 360 35,9% 167 1.452E-43
4 phalp2_20154
415G3
 53 44,9% 158 2.470E-42
5 phalp2_2504
5ItIB
 4 44,3% 115 3.802E-40
6 phalp2_1105
7uQkD
 25 48,2% 114 8.000E-38
7 phalp2_13877
7xeAe
 2 41,3% 121 1.004E-30
8 phalp2_30831
8IEyq
 212 32,8% 152 2.824E-25
9 phalp2_12594
1nLjj
 56 40,8% 159 3.863E-25
10 phalp2_36427
10262
 294 26,9% 156 1.738E-09

Domains

Domains [InterPro]
Ami5
Representative sequence (used for alignment): 1csV3 (175 AA)
Member sequence: A0A4D6AFW1 (239 AA)
1 175 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF05382

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan5
[NCBI] 		2548214 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448781 [NCBI]
CDS location
range 37248 -> 37967
strand +
CDS
ATGGTAATTAATATTGAGCAAGCTATCGCATGGATGGCATCTAGAAAAGGTAAAGTTACTTACTCGATGGACTATCGAAATGGTCCTTCATCTTACGATTGCTCTAGCTCTGTCTATTTTGCTCTACGCTCAGCAGGCGCATCAGATAATGGCTGGGCAGTAAATACAGAATATGAGCACGATTGGTTGATAAAAAACGGTTATGTTCTTATTGCAGAAAATACTAATTGGAATGCGCAAAGAGGTGATATTTTTATTTGGGGTAAACGTGGGGCTTCGGCTGGAGCTTTTGGACATACTGGTATGTTTGTTGATCCAGACAATATTATTCACTGTAATTATGGTTATAACTCAATTACAGTGAATAACCATGATGAAATCTGGGGATATAATGGTCAACCTTATGTTTACGCTTATCGTTACGCTAGGAAACAGTCAAATGCTAAGGTTGATAATCAATCAGTTGTATCTAAATTTGAAAAAGAGTTAGACGTTAACACACCGCTAAGTAATTCAAATATGCCATATTACGAAGCAACAATTTCAGAAGATTATTACGTTGAGTCCAAGCCTGACGTCAATAGCACTGATAAGGAGTTGCTTGTTGCTGGTACTAGAGTTCGAGTTTACGAAAAAGTAAAAGGCTGGGCAAGGATAGGCGCTCCACAGTCTAATCAGTGGGTAGAAGATGCTTACTTAATTGATGCAACAGATATGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008234 cysteine-type peptidase activity molecular function None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
A0A4D6A3T3
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A4D6ACP0
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A4D6AFW1
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A4D6AZZ6
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
A0A4D6B027
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50

Showing first 5 of 8 structures.

The structures below correspond to the cluster representative (1csV3) rather than this protein.
PDB ID
1csV3
Method AlphaFoldv2
Resolution 88.90
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50