Protein

Protein accession
A0A385UI25 [UniProt]
Representative
8hjZU
Source
UniProt (cluster: phalp2_24103)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVTMPVEKDFYVTSGFGPRWGTHHWGVDFGAPGGSGGRPVYAVKDGTVARSGPASGFGQWVGIDHPATNGGGETIYGHIIPEVKAGQQVKEGQRIGHINPNRATNGGVDPHLHLEWHRYTWTPPGPDRLDPMKKLTGARWPGEKDTTMTDNAVDIDLHHLIPFGRPTPLPKKIIIVHTTENAPGTPSRNIIDYQVRTQSGSYHRLVDATGKITMANTDDWQTWSTGNKGNDIALHVSCVAQAKMTREQWLAQPKMLEGVARVIAHWSKKYQIPLVKLSRAELGAGKHGVAGHLEAQVWGNTTHWDPGYHFPYDVVLRRAAEINKPAAPEKEPAPVPQITVPDTTAPQADRDQLIYEQLCGPGAPGTFPGWPQLGNRTLVDAVAAIGDKLGIDGFKSPLIGDAAAGAPK
Physico‐chemical
properties
protein length:408 AA
molecular weight:44169,3 Da
isoelectric point:7,86
hydropathy:-0,48
Representative Protein Details
Accession
8hjZU
Protein name
8hjZU
Sequence length
286 AA
Molecular weight
31319,20580 Da
Isoelectric point
4,85879
Sequence
MATMPVEQGFYVTSPFGNRDGEWAGMHWGTDFGHDGGSGGYPVFAVKSGTVQYAGGASGFGMWVTIDHPTEVGGGYSVYGHVVPEVVPGQWVNEGDRIARINPDSSTNGGVAPHLHFEWHRYSWSQPGPDRLDPMATVLAGATWPGGAPVTVTENPREENMSEVIYGIDISNHQPDIDLNQVKREGFEWVIIKANEGTWRDRFCRRHIDAARAAGLEVAVYCYVVNDASPDEHADTLHEVVGGDTSLPVALDIEDGSGYDVGHFHRVKDAIEARGYRVFLTYMPSW
Other Proteins in cluster: phalp2_24103
Total (incl. this protein): 14 Avg length: 348,8 Avg pI: 6,05
Protein ID Length (AA) pI
8hjZU 286 4,85879
6lg44 233 4,87732
7gBO7 318 8,42674
8nf2X 285 4,84049
KJdQ 219 4,56158
x5ID 376 5,03636
A0A4Y6EMJ0 410 6,62540
A0A4Y6EMZ2 408 7,02458
A0A514DJG8 410 6,59715
D4P815 478 5,30509
A0A1P8D5Q3 473 5,33107
A0A515MK78 171 6,01580
A0A3G3LXC7 408 7,33515
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36852
7d3iJ
 93 52,0% 290 9.240E-112
2 phalp2_11336
7m67S
 15 22,8% 210 3.589E-14

Domains

Domains [InterPro]
PET_M23
GH25
Representative sequence (used for alignment): 8hjZU (286 AA)
Member sequence: A0A385UI25 (408 AA)
1 286 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01551

Taxonomy

  Name Taxonomy ID Lineage
Phage Corynebacterium phage SamW
[NCBI] 		2301601 Samwavirus > Samwavirus samW
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH727560 [NCBI]
CDS location
range 19818 -> 21044
strand +
CDS
ATGGTCACCATGCCCGTGGAGAAAGACTTCTACGTCACGTCCGGTTTCGGCCCCCGGTGGGGCACCCATCATTGGGGCGTCGATTTCGGTGCCCCGGGCGGCTCCGGTGGACGCCCCGTCTACGCCGTCAAAGACGGCACCGTCGCCCGCTCCGGCCCCGCGTCGGGCTTCGGCCAATGGGTCGGCATCGACCACCCCGCCACCAACGGCGGCGGCGAAACGATCTACGGCCACATCATCCCCGAGGTGAAGGCAGGCCAGCAGGTGAAGGAAGGCCAGCGCATCGGCCACATCAACCCCAACCGAGCCACCAACGGCGGCGTCGACCCCCACCTCCACCTCGAATGGCACCGCTACACCTGGACCCCACCCGGCCCCGACCGACTCGACCCCATGAAAAAACTCACCGGCGCACGCTGGCCCGGAGAAAAGGACACCACCATGACGGACAACGCCGTCGACATCGACCTCCACCACCTCATCCCCTTCGGGCGGCCGACCCCGCTGCCGAAGAAGATCATCATCGTCCACACCACGGAGAATGCCCCCGGCACCCCGTCGCGCAACATCATCGACTACCAGGTCCGCACCCAGTCCGGCTCCTACCACCGGCTGGTCGACGCCACCGGCAAAATCACCATGGCGAACACCGACGACTGGCAGACCTGGTCGACGGGCAACAAGGGCAACGACATCGCCCTCCACGTGTCCTGCGTCGCGCAGGCGAAAATGACCCGCGAGCAGTGGCTCGCCCAGCCGAAGATGCTGGAGGGCGTCGCCCGCGTCATCGCCCACTGGTCCAAGAAGTACCAGATTCCCCTGGTCAAGCTGTCCCGCGCCGAACTCGGGGCAGGCAAGCACGGCGTCGCCGGGCACCTCGAAGCCCAGGTATGGGGCAACACGACCCACTGGGACCCCGGCTACCACTTCCCCTACGACGTGGTTCTGCGTCGCGCTGCCGAGATCAATAAGCCCGCCGCCCCGGAGAAGGAGCCCGCCCCCGTGCCCCAGATCACCGTCCCCGACACCACCGCCCCGCAGGCCGACCGCGACCAGCTCATCTATGAGCAACTGTGCGGCCCCGGCGCGCCGGGCACCTTCCCCGGCTGGCCGCAGCTCGGCAACCGCACCCTCGTCGACGCGGTCGCCGCAATTGGCGACAAGCTCGGAATCGACGGCTTCAAGTCCCCGCTGATTGGCGACGCCGCCGCCGGCGCCCCCAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8hjZU) rather than this protein.
PDB ID
8hjZU
Method AlphaFoldv2
Resolution 90.98
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50