Protein

Protein accession
A0A1L7DS69 [UniProt]
Representative
1LaGk
Source
UniProt (cluster: phalp2_26423)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MTALKNTVMAAVAAAGLTGAFTLVDRFEWTGKETRTYVDPVGVATICRGHTGPLTKKGSATLAECDDATLKDLLTAQKVVRSCTTVPMTPGEMNAWTSFAFNVGPGRAGVKDGFCRLKNGRIPTHIAYIESHQPVKACGMLMSWTMPGTSVHSGLKKRREAEMALCLSDLR
Physico‐chemical
properties
protein length:171 AA
molecular weight:18334,1 Da
isoelectric point:9,28
hydropathy:-0,07
Representative Protein Details
Accession
1LaGk
Protein name
1LaGk
Sequence length
259 AA
Molecular weight
26978,34750 Da
Isoelectric point
9,42620
Sequence
VSTGRVLVAALTLSAAGLIGIAVSEGWEPVARPPVPGDVPTGGFGSTRGESGPMRPGERIDPVRGLILLQRDASEAERIVRRCAPVPMHQREFDAFVSLAYNVGPGKAGVKDGFCELKRGGPSTIVRRLRAGDYKGACDAILSWDRFQGKPLRGADAAPPARARGLHHSGAAQTLNTWDAWCWAVSPTNAKLYRNGAQVYSGAHSGLANPAGVSFRCAVGNGLGAPGSNTGGIRAHIDELVIVKGWAGDISGITSEIVL
Other Proteins in cluster: phalp2_26423
Total (incl. this protein): 3 Avg length: 203,0 Avg pI: 9,31
Protein ID Length (AA) pI
1LaGk 259 9,42620
U3TK98 179 9,21609
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_15849
4kKIv
 1444 47,8% 163 3.749E-30
2 phalp2_28113
7zmZV
 50 33,1% 166 2.006E-12

Domains

Domains [InterPro]
Unannotated
Disordered region
Representative sequence (used for alignment): 1LaGk (259 AA)
Member sequence: A0A1L7DS69 (171 AA)
1 259 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated

Taxonomy

  Name Taxonomy ID Lineage
Phage Ralstonia phage phiAp1
[NCBI] 		2783867 Autographiviridae > Ayakvirus > Ayakvirus Ap1
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KY117485 [NCBI]
CDS location
range 42614 -> 43129
strand +
CDS
ATGACAGCACTGAAGAACACAGTGATGGCGGCGGTAGCCGCAGCGGGCCTGACCGGCGCGTTCACGTTGGTGGACCGCTTCGAGTGGACCGGCAAGGAGACGCGGACCTACGTGGACCCGGTGGGAGTGGCTACCATCTGTCGGGGGCACACTGGTCCCCTGACGAAGAAGGGAAGCGCGACGCTCGCTGAGTGCGACGACGCGACGCTGAAGGACTTGCTCACGGCCCAAAAGGTCGTGCGCTCCTGCACCACTGTGCCCATGACGCCCGGTGAGATGAACGCGTGGACTTCCTTCGCCTTCAACGTGGGGCCGGGCCGTGCCGGTGTGAAGGACGGTTTCTGCCGTCTGAAGAACGGACGGATTCCCACCCACATAGCATACATCGAAAGCCACCAGCCTGTCAAGGCATGCGGCATGTTGATGTCGTGGACCATGCCGGGCACCTCCGTCCACAGCGGCCTGAAGAAGCGCCGAGAGGCGGAGATGGCCCTTTGCCTAAGTGACCTGAGATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (1LaGk) rather than this protein.
PDB ID
1LaGk
Method AlphaFoldv2
Resolution 61.74
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50