Protein

Protein accession
A0A2P0VPI1 [UniProt]
Representative
496b4
Source
UniProt (cluster: phalp2_37702)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MGVLTASLAGLAFITSGEKREYQAYADPALGWKVPTICDGHTGPDVYRGQRANDAMCDAWRAKDAQVSVSAIRRCSGAAKLTQNEFDALVSLVHNIGPAAYCGSTMSRLIREGKLEQVPAQFDRWVYSGGKKLRGLVNRRQSERKLWEVGDYGPVR
Physico‐chemical
properties
protein length:156 AA
molecular weight:17134,3 Da
isoelectric point:9,30
hydropathy:-0,38
Representative Protein Details
Accession
496b4
Protein name
496b4
Sequence length
434 AA
Molecular weight
46346,28460 Da
Isoelectric point
5,21324
Sequence
NNWVEMAADGSIDIYAKSDISIRSQGSMNLRADLDVNIEAGRSIFMKARNDPGTPLGDFGGGLIKMNANVDLHMSADVGVYMTAGEDCNRTAGGDILDKADGDGNYKAVGSVFIQGDEGDVDIKAAAEIHMTATNIHFNSVGAEDATGASDAEDPQDLQQKDAKVVSDGNIQVIVRDTIMYRLPYHEPYPYHGGSVSGTNGHVTAAEPKTDENLQLIRTGEISSNQDKPNDIVGSPRAGMPAGKYSGQSYDDKGNPVYKYEGGSKDLVPSGSLKISDSGLQFIKRYEGLKKTVYLDVAGLKTVGYGHLLTKPELSSNSVTIGGKKIFLDRALTDAEVDTLLRQDIEPKAQTVRSTIKTPLTQSQFDALVSLCFNIGSGAFASSTLAKDINAGNLEKAPGDFLMWCKAGGKTVKGLLNRRQAEASIFRGMPPTNH
Other Proteins in cluster: phalp2_37702
Total (incl. this protein): 7 Avg length: 360,3 Avg pI: 6,52
Protein ID Length (AA) pI
496b4 434 5,21324
1hDJX 502 5,11280
2DJRr 440 6,05821
2DQCE 391 6,15324
4QTkW 434 4,89068
A0A8S5L6B7 165 8,92321
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_17543
5IWUp
 3 31,2% 448 4.385E-64
2 phalp2_33749
10T6t
 3 25,7% 649 4.674E-58
3 phalp2_13752
6LU4E
 2 35,1% 299 4.702E-52
4 phalp2_39498
5k0e3
 3 24,9% 509 1.032E-38
5 phalp2_9564
1hHxt
 1 25,7% 396 7.816E-28
6 phalp2_2483
5BcCC
 40 26,1% 447 7.197E-21

Domains

Domains [InterPro]

No domain annotations available.

Taxonomy

  Name Taxonomy ID Lineage
Phage Ralstonia phage RsoP1IDN
[NCBI] 		2060091 Autographiviridae > Higashivirus > Higashivirus RsoP1IDN
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG652450 [NCBI]
CDS location
range 39591 -> 40061
strand +
CDS
GTGGGCGTGCTCACGGCCTCGCTGGCGGGGCTGGCCTTCATCACGTCTGGGGAGAAGCGGGAGTATCAGGCATACGCCGATCCCGCCCTCGGCTGGAAAGTCCCGACCATCTGCGACGGGCACACCGGGCCGGACGTGTACCGAGGCCAGCGTGCCAACGACGCGATGTGCGATGCTTGGCGGGCCAAGGATGCTCAGGTATCCGTCTCGGCCATCCGGCGCTGCTCCGGCGCCGCCAAGCTGACCCAGAACGAGTTCGACGCTCTAGTGTCGCTCGTCCATAACATTGGCCCCGCCGCGTACTGCGGGAGCACCATGAGCCGCTTGATCCGCGAGGGCAAGCTGGAACAGGTGCCCGCCCAGTTCGACAGGTGGGTGTACTCAGGAGGCAAGAAGCTGCGCGGCCTCGTAAATCGACGCCAGAGCGAACGAAAGCTCTGGGAGGTAGGCGACTATGGGCCTGTTCGATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (496b4) rather than this protein.
PDB ID
496b4
Method AlphaFoldv2
Resolution 83.05
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50